Research output per year
Research output per year
Organization profile
Organization profile
Director: Kent Vrana, PhD
Scientific director: Wesley Raup-Konsavage, PhD
The Center for Cannabis and Natural Product Pharmaceutics (CCNPP) was established to expand upon the scientific progress of the state-approved medical marijuana academic clinical research center at Penn State. While, Cannabis will remain an integral part of the research conducted by the center, interests will also encompass other natural products in both basic and clinical science studies for a wide range of diseases and disorders. Current projects outside of cannabis include research on decursinol (derived from Angelica gigas), schweinfurthins (from Macaranga), pawhuskins (from Dalea), among others. Diseases and disorders currently being studied include: cancer, pain (particularly chemotherapeutic-induced peripheral neuropathy), inflammatory bowel disease, and high blood pressure. Other areas of interest include the growth and cultivation of plants of medicinal importance, using artificial intelligence to examine complex botanical mixtures, and synthesis of novel compounds based upon natural products. It is important to note that the CCNPP provides ready access to infrastructure for natural product extraction and analytical chemistry analysis. In addition, a variety of biological science pipelines (animal assessments, cell culture analysis, etc.) have already been established and are available.
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Dive into the research topics where Center for Cannabis and Natural Product Pharmaceuticals (CCNPP) is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
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Profiles
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Emily Ansell
- Biobehavioral Health - Associate Professor
- Penn State Neuroscience Institute
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
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Ashley Nicole Carmichael
- Biobehavioral Health - Associate Research Professor
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
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Neil Christensen, MSc, PhD
- Department of Pathology and Laboratory Medicine - Professor
- Division of Experimental Pathology
- Department of Microbiology and Immunology - Professor
- Penn State Cancer Institute
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
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Matthew Coates, MD, PhD
- Department of Medicine - Peter and Marshia Carlino Professor
- Division of Gastroenterology and Hepatology - Director of Research
- Department of Pharmacology - Professor
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
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Nikolay Dokholyan, PhD, MS
- Department of Pharmacology - G. Thomas Passananti Professor and Vice Chair for Research
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Clinical and Translational Science Institute (CTSI) - Associate Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
- Penn State Neuroscience Institute
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
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Reyad Elbarbary, PhD
- Department of Orthopaedics and Rehabilitation - Associate Professor
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
Research output
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2-Deoxyglucose and hydroxychloroquine HPLC-MS–MS analytical methods and pharmacokinetic interactions after oral co-administration in male rats
Sun, D., Kim, S., Karelia, D., Deng, Y., Jiang, C. & Junxuan, L., Feb 2024, In: Pharmacology Research and Perspectives. 12, 1, e1173.Research output: Contribution to journal › Article › peer-review
Open Access -
A Comparison of Mental Health Symptoms among Adults Who Vape Nicotine, Cannabis, or Both
Salinas, K. Z., Saran, S., Saulnier, K., Hoglen, B., Houser, K. R., Krebs, N. M., Kaynak, Ö., Bordner, C. R., Yingst, J. M., Foulds, J., Allen, S. I. & Hobkirk, A. L., 2024, In: Substance Use and Misuse. 59, 4, p. 601-607 7 p.Research output: Contribution to journal › Article › peer-review
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Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.Research output: Contribution to journal › Article › peer-review
Open Access -
Activity of DNA polymerase κ across the genome in human fibroblasts
Torres, M. C., Rebok, A., Sun, D. & Spratt, T. E., Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 28, e2403130121.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute kidney injury in hospitalized children with proteinuria: A multicenter retrospective analysis
Baggett, K. H., Manghi, T., Walter, V., Thomas, N. J., Freeman, M. A. & Krawiec, C., Mar 2024, In: PloS one. 19, 3 March, e0298463.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes
Paudel, B. B., Tan, S. F., Fox, T. E., Ung, J., Golla, U., Shaw, J. J. P., Dunton, W., Lee, I., Fares, W. A., Patel, S., Sharma, A., Viny, A. D., Barth, B. M., Tallman, M. S., Cabot, M., Garrett-Bakelman, F. E., Levine, R. L., Kester, M., Feith, D. J. & Claxton, D. & 2 others, , Mar 12 2024, In: Blood Advances. 8, 5, p. 1137-1142 6 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Addiction Frameworks, Social Stigma, and NIMBY Syndrome: Examining Barriers to Responding to the Opioid Crisis
Kruis, N. E., Kaynak, Ö., Whipple, C., Saylor, E. & Kensinger, W., Mar 2024, In: Contemporary Drug Problems. 51, 1, p. 3-24 22 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
Waidyanatha, S., Collins, B. J., Cristy, T., Embry, M., Gafner, S., Johnson, H., Kellogg, J., Krzykwa, J., Li, S., Mitchell, C. A., Mutlu, E., Pickett, S., You, H., Van Breemen, R. & Baker, T. R., Apr 2024, In: Food and Chemical Toxicology. 186, 114537.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Adverse Tracheal Intubation Events in Critically Ill Underweight and Obese Children: Retrospective Study of the National Emergency Airway for Children Registry (2013-2020)
Gladen, K. M., Tellez, D., Napolitano, N., Edwards, L. R., Sanders, R. C., Kojima, T., Malone, M. P., Shults, J., Krawiec, C., Ambati, S., McCarthy, R., Branca, A., Polikoff, L. A., Jung, P., Parsons, S. J., Mallory, P. P., Komeswaran, K., Page-Goertz, C., Toal, M. C. & Bysani, G. K. & 40 others, , Feb 1 2024, In: Pediatric Critical Care Medicine. 25, 2, p. 147-158 12 p.Research output: Contribution to journal › Article › peer-review
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Affect variability in relation to alcohol use frequency, intensity, and concurrent cannabis use among college students during the COVID-19 pandemic
Rahal, D., Linden-Carmichael, A. N. & Lanza, S. T., 2024, In: Addiction Research and Theory. 32, 5, p. 375-383 9 p.Research output: Contribution to journal › Article › peer-review
Open Access
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Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
Arnold, A. (PI) & Gamboa, A. (CoPI)
National Heart, Lung, and Blood Institute
4/15/24 → 3/31/25
Project: Research project
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Planning Pathways to a Diverse Science, Technology, Engineering, and Mathematics Workforce in Northeastern and South-Central Pennsylvania
Ibrahim, R. (CoPI), Rudrabhatla, S. V. (PI), Asempapa, R. (CoPI) & Motevalli, V. (CoPI)
3/15/24 → 2/28/25
Project: Research project
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BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
Morales, A. W. (CoPI), Rudrabhatla, S. V. (PI), Rudrabhatla, S. D. (CoPI), Hill, K. M. (CoPI) & Attaluri, A. (CoPI)
2/1/24 → 1/31/27
Project: Research project
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Biomarker and Analytical Chemistry Core
Richie, J. (PI) & Sun, D. (PI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/25
Project: Research project
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Career Enhancement Core
Hobkirk, A. (PI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/25
Project: Research project
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Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
Muscat, J. (PI), Hobkirk, A. (CoPI), Sun, D. (CoPI), Richie, J. (CoPI), Foulds, J. (CoPI), Liao, J. (CoPI) & Spratt, T. (CoPI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/25
Project: Research project
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Neurobehavioral Effects of Frequent Co-use of Alcohol and Cannabis
Ansell, E. (PI) & Claus, E. (CoPI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 6/30/25
Project: Research project
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Evaluation of peripheral nerve stimulation as an alternative to radiofrequency ablation for facet joint pain
Cortes Correales, D. D. H. (PI) & Gordin, V. (CoPI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/23 → 8/31/26
Project: Research project
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Environmental Chemical Impact on the Host-Microbiome Interaction
Patterson, A. D. (PI)
National Institute of Environmental Health Sciences
6/13/23 → 5/31/25
Project: Research project
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IDENTIFICATION OF DIETARY PHYTOCHEMICALS TO MODULATE CHRONIC GI DISEASES
Kellogg, J. (PI)
National Institute of Food and Agriculture
4/1/23 → 3/31/27
Project: Research project
Prizes
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Dean's Award for Excellence in Teaching
Hussein, R. (Recipient), Stredny, E. (Recipient), Whitley, M. (Recipient), Mnatsakanyan, N. (Recipient), Raimundo, N. (Recipient), Zarnescu, D. (Recipient), Adams, N. (Recipient), Lanza, M. (Recipient), Kowalczyk, A. (Recipient), Travelute, C. (Recipient), Marco, C. (Recipient), Tondt, J. (Recipient), Anderson, A. (Recipient), Heron, C. (Recipient), Newman, R. (Recipient), Richard, D. (Recipient), Scartozzi, C. (Recipient), Dellasega, C. (Recipient), Akhtar, N. (Recipient), Albano-Aluquin, S. (Recipient), Chisty, A. (Recipient), Crook, T. (Recipient), Federici, E. H. (Recipient), Ingram, D. (Recipient), Lakshmanan, P. (Recipient), Mathew, A. (Recipient), Narayana, S. (Recipient), Prokop, A. (Recipient), Razjouyan, H. (Recipient), Tariq, A. (Recipient), Thompson, B. (Recipient), Thompson, E. (Recipient), Trivedi, N. (Recipient), Van Scoy, L. (Recipient), Wong, J. (Recipient), Allie, S. R. (Recipient), Browning, K. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Mamarabadi, M. (Recipient), Shankar, L. (Recipient), Bowie, E. (Recipient), Petfield, J. (Recipient), Whitaker, M. (Recipient), Aynardi, J. (Recipient), Allen, N. (Recipient), Cunningham, B. (Recipient), Gandhi, C. (Recipient), Jairath, B. (Recipient), Lutzkanin, K. M. (Recipient), Kerris, E. (Recipient), Nelson, A. (Recipient), Shook, J. (Recipient), Proctor, E. A. (Recipient), Raup-Konsavage, W. (Recipient), Romanoski, N. (Recipient), Graziane, J. (Recipient), Llorente, A. (Recipient), Nutting, S. (Recipient), Pinto, C. (Recipient), Yingst, J. (Recipient), Zhou, S. (Recipient), Mahase, S. (Recipient), Brian, P. (Recipient), Goldman, E. (Recipient), Maffie, J. (Recipient), Brahmbhatt, R. (Recipient), Fahy, A. (Recipient), Gish, J. (Recipient), Reed, M. F. (Recipient) & Tomasko, J. (Recipient), 2024
Prize