Research output per year
Research output per year
Organization profile
Organization profile
The Cryo-Electron Microscopy (cryo-EM) Core at the Penn State College of Medicine was established in 2020 to meet the modern demand for molecular imaging of both purified and cellular structures, and contains instruments for sample preparation as well as data collection. The crown jewel of the facility is a state-of-the-art Titan Krios (Thermo Fisher) cryo-transmission electron microscope that is fully equipped for automated data collection. In addition, the facility houses a JEM 2100 (JEOL) screening microscope and an LSM-980 (Zeiss) Cryo-Confocal microscope.
RRID:SCR_021178
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Dive into the research topics where CryoEM and CryoET COM Biomedical Core Facility is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cryoelectron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination
Jentink, N., Purnell, C., Kable, B., Swulius, M. T. & Grigoryev, S. A., Sep 21 2023, In: Molecular cell. 83, 18, p. 3236-3252.e7Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit
Kim, C., Schlicksup, C. J., Pérez-Segura, C., Hadden-Perilla, J. A., Wang, J. C. Y. & Zlotnick, A., Sep 2023, In: Journal of Biological Chemistry. 299, 9, 105104.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Visualizing Cofilin-Actin Filaments by Immunofluorescence and CryoEM: Essential Steps for Observing Cofilactin in Cells
Minamide, L. S., Hylton, R., Swulius, M. & Bamburg, J. R., 2023, Methods in Molecular Biology. Humana Press Inc., p. 265-281 17 p. (Methods in Molecular Biology; vol. 2593).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Cofilactin filaments regulate filopodial structure and dynamics in neuronal growth cones
Hylton, R. K., Heebner, J. E., Grillo, M. A. & Swulius, M. T., Dec 2022, In: Nature communications. 13, 1, 2439.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Deep Learning-Based Segmentation of Cryo-Electron Tomograms
Heebner, J. E., Purnell, C., Hylton, R. K., Marsh, M., Grillo, M. A. & Swulius, M. T., Nov 2022, In: Journal of Visualized Experiments. 2022, 189, e64435.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes
Ren, S. C., Qazi, S. A., Towell, B., Wang, J. C. Y. & Mukhopadhyay, S., Mar 2022, In: Journal of virology. 96, 5, e02149-21.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Publisher Correction: Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60 (Scientific Reports, (2021), 11, 1, (14809), 10.1038/s41598-021-94236-y)
Wang, J. C. Y. & Chen, L., Dec 2021, In: Scientific reports. 11, 1, 17372.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
Wang, J. C. Y. & Chen, L., Dec 2021, In: Scientific reports. 11, 1, 14809.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2
Tillinghast, J., Drury, S., Bowser, D., Benn, A. & Lee, K. P. K., Nov 18 2021, In: Molecular cell. 81, 22, p. 4650-4662.e4Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations
Equipment
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COM-CRYOEM-Auto3dem and EMAN2 Workstations
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment
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COM-CRYOEM-JEOL 2100 Transmission Electron Microscope
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment
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COM-CRYOEM-Mark IV Vitrobot
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment
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COM-CRYOEM-Sputter Coater/Glow Dishcharger
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment
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COM-CRYOEM-Titan KRIOS G3i 300 kV
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment
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COM-CRYOEM-Zeiss LSM980 Cryo Spectral Confocal Microscope
CryoEM and CryoET COM Biomedical Core FacilityEquipment/facility: Equipment