Research output per year
Research output per year
Organization profile
Organization profile
The Department of Biochemistry and Molecular Biology at Penn State College of Medicine strives to marry the increasingly powerful tools of genomics and computational biology with the classic approaches of biochemistry and molecular biology to reveal fundamental processes of biology and to convert those discoveries into treatments that improve the well-being of patients.
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Dive into the research topics where Department of Biochemistry and Molecular Biology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
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Profiles
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Cesar Aliaga, MS
- Department of Biochemistry and Molecular Biology - Senior Research Associate
Person: Academic
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Maria Bewley, PhD
- Penn State College of Medicine - Senior Scientific Director, Core Facilities
- Department of Biochemistry and Molecular Biology - Associate Professor
Person: Academic
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James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Department of Otolaryngology - Head and Neck Surgery - Professor
- Institute for Personalized Medicine - Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Kun-Ming Chen, PhD, MS
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
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Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Institute for Computational and Data Sciences (ICDS)
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Gary Clawson, MS, PhD, MD
- Department of Pathology and Laboratory Medicine - Professor Emeritus
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Professor Emeritus
- Penn State Cancer Institute
- Materials Research Institute (MRI)
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Arunangshu Das, MSc, PhD
- Department of Biochemistry and Molecular Biology - Assistant Professor
Person: Academic
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David Degraff, PhD
- Department of Pathology and Laboratory Medicine - Associate Professor
- Division of Experimental Pathology
- Department of Urology - Associate Professor
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Nikolay Dokholyan, PhD, MS
- Department of Pharmacology - G. Thomas Passananti Professor and Vice Chair for Research
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Clinical and Translational Science Institute (CTSI) - Associate Director
- Penn State Cancer Institute
- Penn State Neuroscience Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Research output
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Disease Severity Impairs Generation of Intestinal Organoid Cultures From Inflammatory Bowel Disease Patients
Ding, W., Marx, O. M., Mankarious, M. M., Koltun, W. A. & Yochum, G. S., Jan 2024, In: Journal of Surgical Research. 293, p. 187-195 9 p.Research output: Contribution to journal › Article › peer-review
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Peptide absent sequences emerging in human cancers
Tsiatsianis, G. C., Chan, C. S. Y., Mouratidis, I., Chantzi, N., Tsiatsiani, A. M., Yee, N. S., Zaravinos, A., Kantere, V. & Georgakopoulos-Soares, I., Jan 2024, In: European Journal of Cancer. 196, 113421.Research output: Contribution to journal › Article › peer-review
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Abdominal pain is associated with an increased risk of future healthcare resource utilization in inflammatory bowel disease
Zubrzycka, I., Bogale, K., Stuart, A., Cesaire, M., Walter, V., Dalessio, S., Tinsley, A., Williams, E., Clarke, K. & Coates, M. D., Dec 2023, In: International Journal of Colorectal Disease. 38, 1, 213.Research output: Contribution to journal › Article › peer-review
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A Cartographic Tool to Predict Disease Risk-associated Pseudo-Dynamic Networks from Tissue-specific Gene Expression
Chen, C., Shen, B., Zhang, L., Yu, T., Wang, M. & Wu, R., Jan 5 2023, In: Bio-protocol. 13, 1, e4583.Research output: Contribution to journal › Article › peer-review
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Accurate sequencing of DNA motifs able to form alternative (non-B) structures
Weissensteiner, M. H., Cremona, M. A., Guiblet, W. M., Stoler, N., Harris, R. S., Cechova, M., Eckert, K. A., Chiaromonte, F., Huang, Y. F. & Makova, K. D., Jun 2023, In: Genome research. 33, 6, p. 907-923 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Allosteric inactivation of an engineered optogenetic GTPase
Jain, A., Dokholyan, N. V. & Lee, A. L., Apr 4 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2219254120.Research output: Contribution to journal › Article › peer-review
Open Access -
Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
Ganapathy, A. S., Saha, K., Wang, A., Arumugam, P., Dharmaprakash, V., Yochum, G., Koltun, W., Nighot, M., Perdew, G., Thompson, T. A., Ma, T. & Nighot, P., Jul 25 2023, In: Cell Reports. 42, 7, 112705.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation
Saha, K., Subramenium Ganapathy, A., Wang, A., Arumugam, P., Michael Morris, N., Harris, L., Yochum, G., Koltun, W., Perdew, G. H., Nighot, M., Ma, T. & Nighot, P., 2023, (Accepted/In press) In: Mucosal Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity
Reynolds, J. A., Vishweshwaraiah, Y. L., Chirasani, V. R., Pritchard, J. R. & Dokholyan, N. V., Apr 2023, In: Journal of Biological Chemistry. 299, 4, 103069.Research output: Contribution to journal › Article › peer-review
Open Access -
A noncommutative combinatorial protein logic circuit controls cell orientation in nanoenvironments
Chen, J., Vishweshwaraiah, Y. L., Mailman, R. B., Tabdanov, E. D. & Dokholyan, N. V., May 2023, In: Science Advances. 9, 21, eadg1062.Research output: Contribution to journal › Article › peer-review
Open Access
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Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traits
6/20/23 → 3/31/24
Project: Research project
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Elucidating the consequences of dietary sugar consumption on the gut microbiota
National Institute of Diabetes and Digestive and Kidney Diseases
5/1/23 → 2/29/24
Project: Research project
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Wnt/beta-catenin signaling in early-onset colorectal cancer
4/4/23 → 3/31/24
Project: Research project
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Integrative approaches to understand systemic lupus erythematosus etiology in trans-ancestry genetic studies
National Institute of Allergy and Infectious Diseases
9/20/22 → 7/31/24
Project: Research project
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Harnessing the gut microbiome to detect and quantify glycans
National Institute of General Medical Sciences
9/1/22 → 8/31/24
Project: Research project
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Methods to unveil sex-specific genetic architecture in trans-ancestry meta-analysis
Liu, D. & Jiang, B. B.
National Human Genome Research Institute
8/10/22 → 5/31/24
Project: Research project
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Nanoscale cryo-electron tomographic analysis of nucleosome condensates in neuronal chromatin
NATIONAL INSTITUTE ON DRUG ABUSE
8/1/22 → 7/31/24
Project: Research project
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Deciphering the progression and regulation of human translesion DNA synthesis
National Institute of General Medical Sciences
8/1/22 → 5/31/24
Project: Research project
Activities
- 3 Oral presentation
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Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017Activity: Talk types › Oral presentation
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From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017Activity: Talk types › Oral presentation
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Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017Activity: Talk types › Oral presentation
Prizes
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Career Citation Milestone Award - D (500) Club
Bixler, Edward (Recipient) & Cheng, Keith (Recipient), 2016
Prize
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Career Citation Milestone Award - D (500) Club
Broach, James (Recipient), Coates, Matthew (Recipient), Duffy, Charles (Recipient), Gardner, Andrew (Recipient), Gill, Donald (Recipient), Helm, Klaus (Recipient), Kimball, Scot (Recipient), Leslie, Douglas (Recipient), Lipton, Allan (Recipient), Ma, Thomas (Recipient), Naccarelli, Gerald (Recipient), Schmitz, Kathryn (Recipient), Siedlecki, Christopher (Recipient), Stoute, Jose (Recipient), Tombran-Tink, Joyce (Recipient) & Wang, Hong-Gang (Recipient), 2020
Prize
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Career Citation Milestone Award - D (500) Club
Barber, Alistair (Recipient), Belani, Chandra (Recipient), Bixler, Edward (Recipient), Eslinger, Paul (Recipient), Imamura, Yuka (Recipient), Legro, Richard (Recipient), Mailman, Richard (Recipient), Schiff, Steven (Recipient), Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2019
Prize
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Career Citation Milestone Award - M (1000) Club
Carrel, Laura (Recipient), Cheng, Keith (Recipient) & Chin, Thomas (Recipient), 2020
Prize
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Career Citation Milestone Award - M (1000) Club
Barnstable, Colin (Recipient) & Broach, James (Recipient), 2017
Prize