Department of Cell and Biological Systems

2025

Bilayer or Not: Revisiting the Structural Nature of HBV Subviral Particles

Liu, H., Garg, S., Hu, J. & Wang, J. C. Y., Feb 2025, In: Journal of Medical Virology. 97, 2, e70212.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

Bui, V., Liang, X., Ye, Y., Giang, W., Tian, F., Takahashi, Y. & Wang, H. G., 2025, (Accepted/In press) In: Autophagy.

Research output: Contribution to journal › Article › peer-review

Open Access

Contrast-enhanced magnetic resonance imaging based calf muscle perfusion and machine learning in peripheral artery disease

Khagi, B., Belousova, T., Short, C. M., Taylor, A. A., Bismuth, J., Shah, D. J. & Brunner, G., Dec 2025, In: Scientific reports. 15, 1, 4996.

Research output: Contribution to journal › Article › peer-review

Open Access

Dysregulation of FURIN and Other Proprotein Convertase Genes in the Progression from HPV Infection to Cancer

Izaguirre, G., Zirou, N. & Meyers, C., Jan 2025, In: International journal of molecular sciences. 26, 2, 461.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity

Tsvetkova, I. B., Roos, N., Miller, L. M., DiNunno, N., Conrady, M., Ebert, D., Lilie, H., Scott, L. W., Jarrold, M. F., Wang, J. C. Y., Simon, C. & Dragnea, B., Jan 14 2025, In: ACS nano. 19, 1, p. 479-487 9 p.

Research output: Contribution to journal › Article › peer-review

Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes

Chan, K., Tseng, C., Milarachi, E., Goldrich, D., Schneper, L., Sheldon, K., Aliaga, C., Alam, S., Chatterjee, S., El-Bayoumy, K., Meyers, C., Goldenberg, D. & Broach, J. R., Feb 1 2025, In: Molecular Cancer Research. 23, 2, p. 119-127 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango

Kumar, V. & Bansal, S. S., Jan 2025, In: Biomolecules. 15, 1, 58.

Research output: Contribution to journal › Review article › peer-review

Open Access

Inter-membrane control of junctional InsP₃ receptors by PIP₂

Zhou, Y., Wang, Y. & Gill, D. L., Jan 2025, In: Trends in Cell Biology. 35, 1, p. 1-3 3 p.

Research output: Contribution to journal › Short survey › peer-review

Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma

Kim, S. Y., Tang, M., Chih, S. Y., Sallavanti, J., Gao, Y., Qiu, Z., Wang, H. G. & Li, W., Dec 2025, In: Cell Death and Disease. 16, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

Meeting report – Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases

Waschke, J., Amagai, M., Becker, C., Delmar, M., Duru, F., Garrod, D. R., Gerull, B., Green, K. J., Hertl, M., Kowalczyk, A. P., Niessen, C. M., Nusrat, A., Schinner, C., Schlegel, N., Sivasankar, S., Vielmuth, F. & Spindler, V., Jan 2025, In: Journal of Cell Science. 138, 2, jcs263796.

Research output: Contribution to journal › Article › peer-review

Novel immunologic mechanisms for Fontan-associated liver disease

Angelotti, A., Dhesi, M., Bansal, S. S. & Bradley, E. A., Mar 2025, In: International Journal of Cardiology Congenital Heart Disease. 19, 100554.

Research output: Contribution to journal › Article › peer-review

Open Access

Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response

Hoffman, C. L., Bharathan, N. K., Shibata, Y., Giang, W., Gudjonsson, J. E., Seykora, J. T., Prouty, S. M., Stahley, S. N., Payne, A. S. & Kowalczyk, A., 2025, (Accepted/In press) In: Journal of Investigative Dermatology.

Research output: Contribution to journal › Article › peer-review

Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates

White, J., Choi, Y. B., Zhang, J., Vo, M. T., He, C., Shaikh, K. & Harhaj, E. W., 2025, In: Autophagy. 21, 1, p. 160-177 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey–Hailey, and Grover Disease

Harmon, R. M., Ayers, J. L., McCarthy, E. F., Kowalczyk, A. P., Green, K. J. & Simpson, C. L., Mar 2025, In: Journal of Investigative Dermatology. 145, 3, p. 494-508 15 p.

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy

Sunilkumar, S., Subrahmanian, S. M., Yerlikaya, E. I., Toro, A. L., Harhaj, E. W., Kimball, S. R. & Dennis, M. D., Dec 2025, In: Cell Death and Disease. 16, 1, 79.

Research output: Contribution to journal › Article › peer-review

Open Access

Role of lipids in interorganelle communication

Domingues, N., Pires, J., Milosevic, I. & Raimundo, N., Jan 2025, In: Trends in Cell Biology. 35, 1, p. 46-58 13 p.

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

The mitochondriotropic antioxidants AntiOxBEN₂ and AntiOxCIN₄ are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts

Teixeira, J., Benfeito, S., Carreira, R., Barbosa, A., Amorim, R., Tavares, L. C., Jones, J. G., Raimundo, N., Cagide, F., Oliveira, C., Borges, F., Koopman, W. J. H. & Oliveira, P. J., Apr 1 2025, In: Biochimica et Biophysica Acta - Bioenergetics. 1866, 2, 149535.

Research output: Contribution to journal › Article › peer-review

Understanding Mitochondrial and Lysosomal Dynamics by Fluorescent Microscopy

Dionísio, P. A., Sardão, V. A. & Raimundo, N., 2025, Methods in Molecular Biology. Humana Press Inc., p. 211-221 11 p. (Methods in Molecular Biology; vol. 2878).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Unveiling the Molecular Architecture of HBV Spherical Subviral Particles: Structure, Symmetry, and Lipid Dynamics

Garg, S., Ochetto, A., Hu, J. & Wang, J. C. Y., Jan 2025, In: Viruses. 17, 1, 48.

Research output: Contribution to journal › Review article › peer-review

Open Access

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

Shaikh, K., Bowman, M., McCormick, S. M., Gao, L., Zhang, J., White, J., Tawil, J., Kapoor, A., Arav-Boger, R., Norbury, C. C. & Harhaj, E. W., Jan 17 2025, In: iScience. 28, 1, 111544.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A Combined LC-MS and Immunoassay Approach to Characterize Preservative-Induced Destabilization of Human Papillomavirus Virus-like Particles Adsorbed to an Aluminum-Salt Adjuvant

Caringal, R. T., Hickey, J. M., Sharma, N., Jerajani, K., Bewaji, O., Brendle, S., Christensen, N., Batwal, S., Mahedvi, M., Rao, H., Dogar, V., Chandrasekharan, R., Shaligram, U., Joshi, S. B. & Volkin, D. B., Jun 2024, In: Vaccines. 12, 6, 580.

Research output: Contribution to journal › Article › peer-review

Open Access

A machine learning-based approach to identify peripheral artery disease using texture features from contrast-enhanced magnetic resonance imaging

Khagi, B., Belousova, T., Short, C. M., Taylor, A., Nambi, V., Ballantyne, C. M., Bismuth, J., Shah, D. J. & Brunner, G., Feb 2024, In: Magnetic Resonance Imaging. 106, p. 31-42 12 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

Laughlin, P. M., Young, K., Gonzalez-Gutierrez, G., Wang, J. C. Y. & Zlotnick, A., Nov 2024, In: Journal of Biological Chemistry. 300, 11, 107831.

Research output: Contribution to journal › Article › peer-review

Open Access

An intracellular phosphorus-starvation signal activates the PhoB/PhoR two-component system in Salmonella enterica

Bruna, R. E., Kendra, C. G. & Pontes, M. H., Sep 2024, In: mBio. 15, 9

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism

Sun, H., Li, H., Guan, Y., Yuan, Y., Xu, C., Fu, D., Xie, P., Li, J., Zhao, T., Wang, X., Feng, Y., Wang, H., Gao, S., Yang, S., Shi, Y., Liu, J., Chang, A., Huang, C. & Hao, J., Jun 2024, In: Science Advances. 10, 25, eadj8650.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

BRD4 as an emerging epigenetic therapeutic target for inflammatory bowel disease

Ma, Z., Bolinger, A. A., Pinchuk, I. V., Tian, B. & Zhou, J., Jan 2024, Emerging Therapeutic Targets and Drug Delivery Approaches in IBD. Selaru, F. M. & Peters, D. E. (eds.). Academic Press Inc., p. 203-236 34 p. (Advances in Pharmacology; vol. 101).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Brincidofovir inhibits polyomavirus infection in vivo

Butic, A. B., Katz, Z. E., Jin, G., Fukushima, K., Hazama, M., Lukacher, A. E. & Lauver, M. D., Aug 1 2024, In: mBio. 15, 8

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation

Pham, A. M. & Kwun, H. J., Aug 14 2024, In: mBio. 15, 8, p. e0111724

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles: Polymorphism in Norovirus GI.1

Miller, L. M., Draper, B. E., Wang, J. C. Y. & Jarrold, M. F., Aug 13 2024, In: Analytical Chemistry. 96, 32, p. 13150-13157 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis

Wills, C. A., Liu, X., Chen, L., Zhao, Y., Liu, Z., Spiegelman, V. S., Sundstrom, J. & Wang, H. G., Jul 2024, In: Genes and Diseases. 11, 4, 101017.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

Finnegan, E., Ding, W., Ude, Z., Terer, S., McGivern, T., Blümel, A. M., Kirwan, G., Shao, X., Genua, F., Yin, X., Kel, A., Fattah, S., Myer, P. A., Cryan, S. A., Prehn, J. H. M., O’Connor, D. P., Brennan, L., Yochum, G., Marmion, C. J. & Das, S., Apr 2024, In: Cellular Oncology. 47, 2, p. 533-553 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Domingues, N., Catarino, S., Cristóvão, B., Rodrigues, L., Carvalho, F. A., Sarmento, M. J., Zuzarte, M., Almeida, J., Ribeiro-Rodrigues, T., Correia-Rodrigues, Â., Fernandes, F., Rodrigues-Santos, P., Aasen, T., Santos, N. C., Korolchuk, V. I., Gonçalves, T., Milosevic, I., Raimundo, N. & Girão, H., Sep 2 2024, In: EMBO Journal. 43, 17, p. 3627-3649 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Contrast-Enhanced Magnetic Resonance Imaging Based T1 Mapping and Extracellular Volume Fractions Are Associated with Peripheral Artery Disease

Fitian, A. I., Shieh, M. C., Gimnich, O. A., Belousova, T., Taylor, A. A., Ballantyne, C. M., Bismuth, J., Shah, D. J. & Brunner, G., Jun 2024, In: Journal of Cardiovascular Development and Disease. 11, 6, 181.

Research output: Contribution to journal › Article › peer-review

Open Access

Convolutional Neural Networks to Study Contrast-Enhanced Magnetic Resonance Imaging–Based Skeletal Calf Muscle Perfusion in Peripheral Artery Disease

Khagi, B., Belousova, T., Short, C. M., Taylor, A. A., Bismuth, J., Shah, D. J. & Brunner, G., Jun 1 2024, In: American Journal of Cardiology. 220, p. 56-66 11 p.

Research output: Contribution to journal › Article › peer-review

Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (271), 10.1038/s41392-023-01478-5)

Huang, C., Li, H., Xu, Y., Xu, C., Sun, H., Li, Z., Ge, Y., Wang, H., Zhao, T., Gao, S., Wang, X., Yang, S., Sun, P., Liu, Z., Liu, J., Chang, A. & Hao, J., Dec 2024, In: Signal Transduction and Targeted Therapy. 9, 1, 8.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Correction to: Architecture and dynamics of a desmosome–endoplasmic reticulum complex (Nature Cell Biology, (2023), 25, 6, (823-835), 10.1038/s41556-023-01154-4)

Bharathan, N. K., Giang, W., Hoffman, C. L., Aaron, J. S., Khuon, S., Chew, T. L., Preibisch, S., Trautman, E. T., Heinrich, L., Bogovic, J., Bennett, D., Ackerman, D., Park, W., Petruncio, A., Weigel, A. V., Saalfeld, S., Wayne Vogl, A., Stahley, S. N. & Kowalczyk, A. P., Apr 2024, In: Nature Cell Biology. 26, 4, p. 660 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

1 Scopus citations

Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant

Syed, A., Zhai, J., Guo, B., Zhao, Y., Wang, J. C. Y. & Chen, L., May 2 2024, In: Structure. 32, 5, p. 575-584.e3

Research output: Contribution to journal › Article › peer-review

Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner

Paschall, L., Carrozzi, S., Tabdanov, E., Dhawan, A. & Szczesny, S. E., Feb 2024, In: Journal of Orthopaedic Research. 42, 2, p. 267-276 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids

Arroyo Almenas, F., Törő, G., Szaniszlo, P., Maskey, M., Thanki, K. K., Koltun, W., Yochum, G. S., Pinchuk, I. V., Chao, C., Hellmich, M. R. & Módis, K., Sep 2024, In: Antioxidants. 13, 9, 1067.

Research output: Contribution to journal › Article › peer-review

Open Access

Delayed Onset and Spontaneous Regression of DMBA/TPA–Induced Skin Lesions in Mice Lacking Autoimmune Regulator

Lesko, E. M., Gao, T., Feehan, R. P. & Hobbs, R. P., Jan 2024, In: Journal of Investigative Dermatology. 144, 1, p. 177-181.e2

Research output: Contribution to journal › Article › peer-review

Open Access

Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss

Subrahmanian, S. M., Yerlikaya, E. I., Sunilkumar, S., Toro, A. L., McCurry, C. M., Grillo, S. L., Barber, A. J., Sundstrom, J. & Dennis, M. D., 2024, (Accepted/In press) In: GeroScience.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Detection of Hepatitis B Virus Covalently Closed Circular DNA and Intermediates in Its Formation

Hong, X., Mendenhall, M. A. & Hu, J., 2024, Methods in Molecular Biology. Humana Press Inc., p. 99-111 13 p. (Methods in Molecular Biology; vol. 2837).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

Bodt, S. M. L., Ge, J., Ma, W., Rasicci, D. V., Desetty, R., McCammon, J. A. & Yengo, C. M., Aug 1 2024, In: PNAS Nexus. 3, 8, pgae279.

Research output: Contribution to journal › Article › peer-review

Open Access

Disease Severity Impairs Generation of Intestinal Organoid Cultures From Inflammatory Bowel Disease Patients

Ding, W., Marx, O. M., Mankarious, M. M., Koltun, W. A. & Yochum, G. S., Jan 2024, In: Journal of Surgical Research. 293, p. 187-195 9 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Disruption of the SP-A/SP-R210_L (MYO18Aa) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestation

Guan, Z., Worth, B., Umstead, T. M., Amatya, S., Booth, J. & Chroneos, Z. C., Apr 2024, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 326, 4, p. L508-L513

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types

Izaguirre, G., Phan, L. M. U., Asif, S., Alam, S., Meyers, C. & Rong, L., Jan 2024, In: Viruses. 16, 1, 39.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression

Javed, Z., Shin, D. H., Pan, W., White, S. R., Elhaw, A. T., Kim, Y. S., Kamlapurkar, S., Cheng, Y. Y., Benson, J. C., Abdelnaby, A. E., Phaeton, R., Wang, H. G., Yang, S., Sullivan, M. L. G., St.Croix, C. M., Watkins, S. C., Mullett, S. J., Gelhaus, S. L., Lee, N. & Coffman, L. G. & 5 others, Aird, K., Trebak, M., Mythreye, K., Walter, V. & Hempel, N., Oct 10 2024, In: EMBO Reports. 25, 10, p. 4281-4310 30 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Emerging concepts of myosin 18A isoform mechanobiology in organismal and immune system physiology, development, and function

DeKryger, W. & Chroneos, Z. C., May 31 2024, In: FASEB Journal. 38, 10, e23649.

Research output: Contribution to journal › Review article › peer-review

Open Access

Engineering Microgel Packing to Tailor the Physical and Biological Properties of Gelatin Methacryloyl Granular Hydrogel Scaffolds

Jaberi, A., Kedzierski, A., Kheirabadi, S., Tagay, Y., Ataie, Z., Zavari, S., Naghashnejad, M., Waldron, O., Adhikari, D., Lester, G., Gallagher, C., Borhan, A., Ravnic, D., Tabdanov, E. & Sheikhi, A., Oct 7 2024, In: Advanced Healthcare Materials. 13, 25, 2402489.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis

Hattori, T., Fundora, K. A., Hamamoto, K., Opozda, D. M., Liang, X., Liu, X., Zhang, J., Uzun, Y., Takahashi, Y. & Wang, H. G., 2024, In: Autophagy. 20, 2, p. 349-364 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Department of Cell and Biological Systems

Research output

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