Department of Neuroscience and Experimental Therapeutics

2025

Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice

Smith, G. C., Griffith, K. R., Sicher, A. R., Brockway, D. F., Proctor, E. A. & Crowley, N. A., Jan 2025, In: Neurobiology of Aging. 145, p. 42-54 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Central amygdala neuroimmune signaling in alcohol use disorder

Melkumyan, M., Randall, P. A. & Silberman, Y., Mar 2025, In: Addiction Neuroscience. 14, 100194.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical progression of Parkinson's disease in the early 21st century: Insights from the accelerating medicine partnership (AMP-PD) data

Lewis, M. M., Mailman, R. B., Cheng, X. V., Du, G., Zhang, L., Li, C., De Jesus, S., Tabbal, S. D., Li, R. & Huang, X., Jan 2025, In: Parkinsonism and Related Disorders. 130, 107186.

Research output: Contribution to journal › Article › peer-review

Cross-Species Modeling Identifies Gene Signatures in Type 2 Diabetes Mouse Models Predictive of Inflammatory and Estrogen Signaling Pathways Associated with Alzheimer's Disease Outcomes in Humans

Ball, B. K., Proctor, E. A. & Brubaker, D. K., 2025, In: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 30, p. 426-440 15 p.

Research output: Contribution to journal › Article › peer-review

Evaluating remyelination compounds for new applications in opioid use disorder management

Sharma, G., Wade, Q. & Graziane, N. M., 2025, (Accepted/In press) In: Journal of Addictive Diseases.

Research output: Contribution to journal › Article › peer-review

Extremely Low-Frequency and Low-Intensity Electromagnetic Field Technology (ELF-EMF) Sculpts Microtubules

Lobyntseva, A., Ganaiem, M., Ivashko-Pachima, Y., Barnstable, C., Weisinger, B., Parabucki, A., Segal, Y., Shohami, E. & Gozes, I., Feb 2025, In: European Journal of Neuroscience. 61, 4, e70023.

Research output: Contribution to journal › Article › peer-review

Open Access

Functional knock out of Acid Sensing Ion Channel 3 prevents the exaggerated exercise pressor reflex in rats exercising on a treadmill

Thomas, G., Higgins, S. P., Kuczmarski, M. J., Ducrocq, G. P., Anselmi, L., Ruiz-Velasco, V. & Kaufman, M., Apr 2025, In: Autonomic Neuroscience: Basic and Clinical. 258, 103249.

Research output: Contribution to journal › Article › peer-review

Heat Stroke Management Updates: A Description of the Development of a Novel In-Emergency Department Cold-Water Immersion Protocol and Guide for Implementation

Comp, G., Pugsley, P., Sklar, D., Akhter, M., McElhinny, M., Erickson, E., Feinstein, B., Enenbach, M., Williams, L., Pearlmutter, J. & Stowell, J. R., Jan 2025, In: Annals of Emergency Medicine. 85, 1, p. 43-52 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Intraperitoneal delivery of cannabidiol (CBD) and Δ⁹-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice

Brendle, S. A., Li, J., Sun, D., Zhu, J., Henderson-Redmond, A. N., Morgan, D., Balogh, K. K., Covington, D., Shearer, D. A. & Hu, J., Jun 2025, In: Tumour Virus Research. 19, 200307.

Research output: Contribution to journal › Article › peer-review

Open Access

Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain

Silberfeld, A., Roe, J. M., Ellegood, J., Lerch, J. P., Qiu, L., Kim, Y., Lee, J. G., Hopkins, W. D., Grandjean, J., Ou, Y. & Pourquié, O., Feb 15 2025, In: NeuroImage. 307, 121017.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Problems accessing pain care, and the adverse outcomes among adults with chronic pain: a cross-sectional survey study

Carrillo, M., Yingst, J., Tuan, W. J., Giampetro, D., Nyland, J. E. & Zgierska, A. E., 2025, (Accepted/In press) In: Pain Management.

Research output: Contribution to journal › Article › peer-review

Open Access

RNA-Puzzles Round V: blind predictions of 23 RNA structures

Bu, F., Adam, Y., Adamiak, R. W., Antczak, M., de Aquino, B. R. H., Badepally, N. G., Batey, R. T., Baulin, E. F., Boinski, P., Boniecki, M. J., Bujnicki, J. M., Carpenter, K. A., Chacon, J., Chen, S. J., Chiu, W., Cordero, P., Das, N. K., Das, R., Dawson, W. K. & DiMaio, F. & 79 others, Ding, F., Dock-Bregeon, A. C., Dokholyan, N. V., Dror, R. O., Dunin-Horkawicz, S., Eismann, S., Ennifar, E., Esmaeeli, R., Farsani, M. A., Ferré-D’Amaré, A. R., Geniesse, C., Ghanim, G. E., Guzman, H. V., Hood, I. V., Huang, L., Jain, D. S., Jaryani, F., Jin, L., Joshi, A., Karelina, M., Kieft, J. S., Kladwang, W., Kmiecik, S., Koirala, D., Kollmann, M., Kretsch, R. C., Kurciński, M., Li, J., Li, S., Magnus, M., Masquida, B., Moafinejad, S. N., Mondal, A., Mukherjee, S., Nguyen, T. H. D., Nikolaev, G., Nithin, C., Nye, G., Pandaranadar Jeyeram, I. P. N., Perez, A., Pham, P., Piccirilli, J. A., Pilla, S. P., Pluta, R., Poblete, S., Ponce-Salvatierra, A., Popenda, M., Popenda, L., Pucci, F., Rangan, R., Ray, A., Ren, A., Sarzynska, J., Sha, C. M., Stefaniak, F., Su, Z., Suddala, K. C., Szachniuk, M., Townshend, R., Trachman, R. J., Wang, J., Wang, W., Watkins, A., Wirecki, T. K., Xiao, Y., Xiong, P., Xiong, Y., Yang, J., Yesselman, J. D., Zhang, J., Zhang, Y., Zhang, Z., Zhou, Y., Zok, T., Zhang, D., Zhang, S., Żyła, A., Westhof, E. & Miao, Z., Feb 2025, In: Nature methods. 22, 2, p. 399-411 13 p., 2871.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2024

2'3'-cGAMP interactome identifies 2'3'-cGAMP/ Rab18/FosB signaling in cell migration control independent of innate immunity

Deng, Y., Hahn, Q., Yu, L., Zhu, Z., Boyer, J. A., Wang, J., Kong, D., Carey, L. M., Hepperla, A. J., Simon, J. M., Temple, B., Zhang, Z., Zhang, Y., Santos, C., Frank, J. E., Herring, L. E., Wang, X., Dokholyan, N. V., Campbell, S. L. & Baldwin, A. S. & 3 others, Damania, B., Zhang, Q. & Liu, P., Oct 18 2024, In: Science Advances. 10, 42, eado7024.

Research output: Contribution to journal › Article › peer-review

2-Deoxyglucose and hydroxychloroquine HPLC-MS–MS analytical methods and pharmacokinetic interactions after oral co-administration in male rats

Sun, D., Kim, S., Karelia, D., Deng, Y., Jiang, C. & Junxuan, L., Feb 2024, In: Pharmacology Research and Perspectives. 12, 1, e1173.

Research output: Contribution to journal › Article › peer-review

Open Access

A Call for Change: Updating the Operational Definition for Dementia in Parkinson's Disease

International Parkinson and Movement Disorder Society PD-MCI Study Group, 2024, (Accepted/In press) In: Movement Disorders Clinical Practice.

Research output: Contribution to journal › Article › peer-review

A common variant in the iron regulatory gene (Hfe) alters the metabolic and transcriptional landscape in brain regions vulnerable to neurodegeneration

Marshall Moscon, S., Neely, E., Proctor, E. A. & Connor, J., Sep 2024, In: Journal of neurochemistry. 168, 9, p. 3132-3153 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Comparison of Mental Health Symptoms among Adults Who Vape Nicotine, Cannabis, or Both

Salinas, K. Z., Saran, S., Saulnier, K., Hoglen, B., Houser, K. R., Krebs, N. M., Kaynak, Ö., Bordner, C. R., Yingst, J. M., Foulds, J., Allen, S. I. & Hobkirk, A. L., 2024, In: Substance Use and Misuse. 59, 4, p. 601-607 7 p.

Research output: Contribution to journal › Article › peer-review

Actigraphy measures show sleep improvement after parathyroidectomy for primary hyperparathyroidism

Chan, K., Tseng, C. C., Milarachi, E., Goldrich, D. Y., King, T. S., Fernandez-Mendoza, J., Saadi, R. A., Saunders, B., Boltz, M. & Goldenberg, D., Jul 1 2024, In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 45, 4, 104297.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Activity of DNA polymerase κ across the genome in human fibroblasts

Torres, M. C., Rebok, A., Sun, D. & Spratt, T. E., Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 28, e2403130121.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Age-related differences in the association of mild-to-moderate sleep apnea with incident cardiovascular and cerebrovascular diseases

Vgontzas, A. N., He, F., Fernandez-Mendoza, J., Karagkouni, E., Pejovic, S., Karataraki, M., Li, Y. & Bixler, E. O., Jan 2024, In: Sleep Medicine. 113, p. 306-312 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

Bennett, H. C., Zhang, Q., Wu, Y. T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H. J., Drew, P. J. & Kim, Y., Dec 2024, In: Nature communications. 15, 1, 6398.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Allosteric modulators of M₁ muscarinic receptors enhance acetylcholine efficacy and decrease locomotor activity and turning behaviors in zebrafish

Widman, C. J., Ventresca, S., Dietrich, J., Elmslie, G., Smith, H., Kaup, G., Wesley, A., Doenecke, M., Williams, F. E., Schiefer, I. T., Ellis, J. & Messer, W. S., Dec 2024, In: Scientific reports. 14, 1, 14901.

Research output: Contribution to journal › Article › peer-review

Open Access

A novel alcohol+nicotine co-use self-administration procedure reveals sex differences and differential alteration of mesocorticolimbic TLR- and cholinergic-related neuroimmune gene expression in rats

Randall, C. A., Sun, D. & Randall, P. A., Dec 2024, In: Alcohol. 121, p. 115-131 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Antinociceptive Effects of Cannabichromene (CBC) in Mice: Insights from von Frey, Tail-Flick, Formalin, and Acetone Tests

Raup-Konsavage, W. M., Sepulveda, D. E., Wang, J., Dokholyan, N. V., Vrana, K. E. & Graziane, N. M., Jan 2024, In: Biomedicines. 12, 1, 83.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

A PEDF peptide mimetic effectively relieves dry eye in a diabetic murine model by restoring corneal nerve, barrier, and lacrimal gland function

Chen, S., Barnstable, C. J., Zhang, X., Li, X., Zhao, S. & Tombran-Tink, J., Apr 2024, In: Ocular Surface. 32, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Vishweshwaraiah, Y. L., Hnath, B., Wang, J., Chandler, M., Mukherjee, A., Yennawar, N. H., Booker, S. J., Afonin, K. A. & Dokholyan, N. V., May 20 2024, In: ACS Applied Bio Materials. 7, 5, p. 3238-3246 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Associations of pre-diagnosis physical activity with treatment tolerance and treatment efficacy in breast cancer patients with neoadjuvant chemotherapy

Lin, D., Sturgeon, K. M., Muscat, J. E., Zhou, S., Hobkirk, A. L., O’Brien, K. M., Sandler, D. P. & Thompson, C. L., May 2024, In: Breast Cancer. 31, 3, p. 519-528 10 p.

Research output: Contribution to journal › Article › peer-review

Barriers to identifying and addressing health-related social needs in cancer care: Patient and patient navigator perspectives

Henry, T., Hayes, M., Eisele, C. D., Veldheer, S., Allen, S. I., Hoglen, B., Houser, K. R., Lengerich, E. J., Rodriguez-Colon, S. M., Jenkins, A. C. & Hobkirk, A. L., Dec 2024, In: Journal of Cancer Policy. 42, 100508.

Research output: Contribution to journal › Article › peer-review

Cannabinoid Awareness, Reporting Use to Health Care Providers, and Perceptions Regarding Safety - Pennsylvania, March 2023-April 2023

Kocis, P. T., Mallinson, D. J. & Servinsky, T. J., Jul 17 2024, In: Medical Cannabis and Cannabinoids. 7, 1, p. 119-124 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor

Hengst, J. A., Ruiz-Velasco, V. J., Raup-Konsavage, W. M., Vrana, K. E. & Yun, J., Dec 2024, In: Cancers. 16, 23, 3973.

Research output: Contribution to journal › Article › peer-review

Open Access

Cannabinoids as Potential Cancer Therapeutics: The Concentration Conundrum

Carkaci-Salli, N., Raup-Konsavage, W. M., Karelia, D., Sun, D., Jiang, C., Lu, J. & Vrana, K. E., Aug 1 2024, In: Cannabis and Cannabinoid Research. 9, 4, p. e1159-e1169

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents

Morales-Ghinaglia, N., He, F., Calhoun, S. L., Vgontzas, A. N., Liao, J., Liao, D., Bixler, E. O. & Fernandez-Mendoza, J., Jan 1 2024, In: Sleep. 47, 1, zsad262.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Clinical characterization of the silent chronic pancreatitis patient: a single-center retrospective cohort study

Amakye, D., Bundschuh, M., Walter, V., Headlee, B., Razjouyan, H. & Coates, M., Sep 13 2024, In: Annals of Gastroenterology. 37, 5, p. 618-622 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical outcomes associated with antidepressant use in inflammatory bowel disease patients and a matched control cohort

Ba, D. M., Yadav, S., Liu, G., Leslie, D. L., Vrana, K. E. & Coates, M. D., Dec 2024, In: Scientific reports. 14, 1, 1060.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Coexpressed δ-, μ-, and к-Opioid Receptors Modulate Voltage-Gated Ca²⁺ Channels in Gastric-Projecting Vagal Afferent Neurons

Goudsward, H. J., Ruiz-Velasco, V., Stella, S. L., Willing, L. B. & Holmes, G. M., Mar 1 2024, In: Molecular pharmacology. 105, 3, p. 250-259 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement

Sforza, M., Morin, C. M., Dang-Vu, T. T., Pomares, F. B., Perrault, A. A., Gouin, J. P., Bušková, J., Janků, K., Vgontzas, A., Fernandez-Mendoza, J., Bastien, C. H., Riemann, D., Baglioni, C., Carollo, G., Casoni, F., Zucconi, M., Castronovo, V., Galbiati, A. & Ferini-Strambi, L., 2024, (Accepted/In press) In: Journal of Sleep Research.

Research output: Contribution to journal › Article › peer-review

Concurrent and Longitudinal Predictors and Stability of Parent-Reported Sleep Problems in a Population-Based Sample at Mean Ages 8 and 15

Mayes, S. D., Fernandez-Mendoza, J., Waschbusch, D. A. & Calhoun, S. L., Mar 2024, In: Journal of Psychopathology and Behavioral Assessment. 46, 1, p. 103-115 13 p.

Research output: Contribution to journal › Article › peer-review

Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala

Prakash, N., Matos, H. Y., Sebaoui, S., Tsai, L., Tran, T., Aromolaran, A., Atrachji, I., Campbell, N., Goodrich, M., Hernandez-Pineda, D., Herrero, M. J., Hirata, T., Lischinsky, J., Martinez, W., Torii, S., Yamashita, S., Hosseini, H., Sokolowski, K., Esumi, S. & Kawasawa, Y. I. & 3 others, Hashimoto-Torii, K., Jones, K. S. & Corbin, J. G., Feb 2024, In: Journal of Comparative Neurology. 532, 2, e25545.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

C-reactive protein improves the ability to detect hypertension and insulin resistance in mild-to-moderate obstructive sleep apnea: Age effect

Pejovic, S., Shang, Y., Vgontzas, A. N., Fernandez-Mendoza, J., He, F., Li, Y. & Kong, L., 2024, (Accepted/In press) In: Journal of Sleep Research.

Research output: Contribution to journal › Article › peer-review

Open Access

Cross-modality mapping using image varifolds to align tissue-scale atlases to molecular-scale measures with application to 2D brain sections

Stouffer, K. M., Trouvé, A., Younes, L., Kunst, M., Ng, L., Zeng, H., Anant, M., Fan, J., Kim, Y., Chen, X., Rue, M. & Miller, M. I., Dec 2024, In: Nature communications. 15, 1, 3530.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Delay Discounting Validity and E-Cigarette Use: A Comparison in E-Cigarette Users, Combustible Cigarette Users, Dual Users, and Nonusers

Kim, J. Y., Reed, D. D., Strickland, J. C., Hobkirk, A., Foulds, J., Seacord, N. F. & Ditzler, H. M., Nov 7 2024, In: Experimental and clinical psychopharmacology. 33, 1, p. 68-76 9 p.

Research output: Contribution to journal › Article › peer-review

Developmental mouse brain common coordinate framework

Kronman, F. N., Liwang, J. K., Betty, R., Vanselow, D. J., Wu, Y. T., Tustison, N. J., Bhandiwad, A., Manjila, S. B., Minteer, J. A., Shin, D., Lee, C. H., Patil, R., Duda, J. T., Xue, J., Lin, Y., Cheng, K. C., Puelles, L., Gee, J. C., Zhang, J. & Ng, L. & 1 others, Kim, Y., Dec 2024, In: Nature communications. 15, 1, 9072.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

DFMO inhibition of neuroblastoma tumorigenesis

Gandra, D., Mulama, D. H., Foureau, D. M., McKinney, K. Q., Kim, E., Smith, K., Haw, J., Nagulapally, A. & Saulnier Sholler, G. L., May 2024, In: Cancer medicine. 13, 9, e7207.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Differences in withdrawal symptoms, microglia activity, and cognitive functioning in rats exposed to continuous low-dose heroin in-utero

Mills-Huffnagle, S. L., Zawatsky, C. N., Bryant, G., Ebert, M., Augusto, C. M., Sipe, A., Horvath, N. & Nyland, J. E., Sep 1 2024, In: Neurotoxicology and Teratology. 105, 107385.

Research output: Contribution to journal › Article › peer-review

Differentiable rotamer sampling with molecular force fields

Sha, C. M., Wang, J. & Dokholyan, N. V., Jan 1 2024, In: Briefings in bioinformatics. 25, 1, slad183.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites

Ball, B. K., Kuhn, M. K., Fleeman Bechtel, R. M., Proctor, E. A. & Brubaker, D. K., Dec 2024, In: Scientific reports. 14, 1, 12743.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Distributed X chromosome inactivation in brain circuitry is associated with X-linked disease penetrance of behavior

Szelenyi, E. R., Fisenne, D., Knox, J. E., Harris, J. A., Gornet, J. A., Palaniswamy, R., Kim, Y., Venkataraju, K. U. & Osten, P., Apr 23 2024, In: Cell Reports. 43, 4, 114068.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?

Fernandes, I. A., Stavres, J., Hamaoka, T., Ojikutu, Q. A., Sabino-Carvalho, J. L., Vianna, L. C., Luck, J. C., Blaha, C., Cauffman, A. E., Dalton, P. C., Herr, M. D., Ruiz-Velasco, V., Carr, Z., Janicki, P. K. & Cui, J., Sep 2024, In: Journal of neurophysiology. 132, 3, p. 922-928 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Dopamine D₁ Receptor Agonists Rescue Age-related Decline in Temporal Order Memory

Bransom, L., Bassett, A. P., Zhou, M., Cimino, J. X., Mailman, R. B. & Yang, Y., Jul 23 2024, In: Neuroscience. 551, p. 177-184 8 p.

Research output: Contribution to journal › Article › peer-review

Ecological momentary assessment and cue-elicited drug craving as primary endpoints: study protocol for a randomized, double-blind, placebo-controlled clinical trial testing the efficacy of a GLP-1 receptor agonist in opioid use disorder

Freet, C. S., Evans, B., Brick, T. R., Deneke, E., Wasserman, E. J., Ballard, S. M., Stankoski, D. M., Kong, L., Raja-Khan, N., Nyland, J. E., Arnold, A. C., Krishnamurthy, V. B., Fernandez-Mendoza, J., Cleveland, H. H., Scioli, A. D., Molchanow, A., Messner, A. E., Ayaz, H., Grigson, P. S. & Bunce, S. C., Dec 2024, In: Addiction Science and Clinical Practice. 19, 1, 56.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Department of Neuroscience and Experimental Therapeutics

Research output

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