Organization profile
Organization profile
Division chief: Kofi Clarke, MD
Division overview: The Division of Gastroenterology and Hepatology at Penn State College of Medicine provides comprehensive management of digestive disorders for adults and operates clinics focusing on general gastroenterology, celiac disease, hepatology, inflammatory bowel disease, motility and therapeutic endoscopy.
Division faculty include clinicians, basic scientists and medical educators. Additional dedicated staff members provide patient- and/or research-related support services for faculty members.
Each year, the division manages more than 17,000 patient-visits at its four clinic locations and undertakes approximately 13,000 endoscopic and/or biopsy procedures at two endoscopy units. The division also maintains an active inpatient consultation service, providing specialty care for thousands of patients at Penn State Health Milton S. Hershey Medical Center each year.
Penn State Gastroenterology and Hepatology faculty are also actively engaged in clinical, basic and translational research, and investigators are funded through a variety of federal and non-federal sponsors. Select research topics of interest include studies of altered intestinal permeability, assessment of motility disorders, management of gastrointestinal and liver cancer, complications of inflammatory bowel disease, development of advanced endoscopic techniques, fatty liver disease and abdominal pain disorders. The division also participates in a variety of cutting-edge clinical trials.
Division faculty members are also involved in medical education and hold key roles in the Internal Medicine residency program, medical student clerkship and College of Medicine leadership.
Finally, faculty serve on several important institutional, regional and national committees related to leadership and/or administration of professional societies in gastroenterology and liver disease.
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Collaborations and top research areas from the last five years
Profiles
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Deborah Bethards, MD
- Department of Medicine - Associate Professor
- Division of Gastroenterology and Hepatology - Director of Clinical Services
Person: Academic
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Kofi Clarke, MD
- Department of Medicine - Graham H. Jeffries Professor
- Division of Gastroenterology and Hepatology - Chief
Person: Academic
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Matthew Coates, MD, PhD
- Department of Medicine - Peter and Marshia Carlino Professor
- Division of Gastroenterology and Hepatology - Director of Research
- Department of Neuroscience and Experimental Therapeutics - Professor
- Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Person: Academic
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Jessica Dahmus, MD
- Department of Medicine - Assistant Professor
- Division of Gastroenterology and Hepatology
Person: Academic
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Zeba Hussaini, MD
- Department of Medicine - Assistant Professor
- Division of Gastroenterology and Hepatology
Person: Academic
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Karen Krok, MD
- Department of Medicine - Professor and Vice Chair for Clinical Affairs
- Division of Gastroenterology and Hepatology - Director of Hepatology
- Penn State Cancer Institute
Person: Academic
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Jennifer Maranki, MD
- Department of Medicine - Professor
- Division of Gastroenterology and Hepatology - Director of Endoscopic Services
Person: Academic
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Abraham Mathew, MD
- Department of Medicine - Professor
- Division of Gastroenterology and Hepatology
- Penn State Cancer Institute
Person: Academic
Research output
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Adverse events of cold snare compared with hot snare and ablation endoscopic mucosal resection for large colorectal polyps
on behalf of the Large Polyp Study Consortium, Feb 1 2026, In: Endoscopy. 58, 2, p. 163-173 11 p.Research output: Contribution to journal › Article › peer-review
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Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index
Channapragada, T., Batra, S., Hummer, B. L., Chinchilli, V. M., Huang, D., Loomba, R., Schreibman, I. R. & Stine, J. G., Feb 2026, In: Digestive Diseases and Sciences. 71, 2, p. 628-635 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Best buys for metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: a global Delphi study
Lazarus, J. V., Agirre-Garrido, L., White, T. M., Arora, A. K., Manolas, M. I., Diaz, L. A., Arab, J. P., Zelber-Sagi, S., Alkhouri, N., Spearman, C. W., Schattenberg, J. M., Kondili, L. A., Carrieri, P., Lofton, H. F., Jaisinghani, P., Kumar, S., Duseja, A., El-Kassas, M., Takahasi, H. & Shawcross, D. L. & 5 others, , Mar 2026, In: The Lancet Gastroenterology and Hepatology. 11, 3, p. 232-242 11 p.Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Scopus citations -
Brief daily functional strength training to improve functional performance in older adults with mobility disability: A randomized trial
Dandekar, S., Kurth, J., Shang, Y., Stine, J. G., Ladwig, M. A., Conroy, D. E., Schmitz, K. H., Rovniak, L. S., Silvis, M., Danilovich, M., Ballentine, N., Pierwola-Gawin, N., Zhou, S. & Sciamanna, C., Mar 2026, In: PloS one. 21, 3 March, e0336748.Research output: Contribution to journal › Article › peer-review
Open Access -
Can regular physical activity keep metabolic dysfunction-associated steatotic liver disease and its complications away before and/or after transplantation
Channapragada, T. V. & Stine, J. G., 2026, In: Current Opinion in Organ Transplantation.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies
Amakye, D. & Clarke, K., 2026, (Accepted/In press) In: Digestive Diseases and Sciences.Research output: Contribution to journal › Review article › peer-review
Open Access -
Comparative efficacy and safety of bi-flanged metal stents versus lumen-apposing metal stents for endoscopic drainage of pancreatic fluid collections: a systematic review and meta-analysis
Shahzil, M., Faisal, M. H., Khan, M. H., Abid, S. F., Shehzadi, M., Faisal, M. S., Chaudhary, A. J., Warraich, M. S. & Maranki, J. L., 2026, (Accepted/In press) In: European Journal of Gastroenterology and Hepatology. 10.1097/MEG.0000000000003190.Research output: Contribution to journal › Article › peer-review
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Does Continuous Positive Airway Pressure Improve Liver Outcomes in MASLD with Obstructive Sleep Apnea? A Systematic Review
Channapragada, T. V., Brenner, C. R., Guruswamy, K., Katamreddy, R., Pandian, A. T., Pendala, V., Sam, J. J., Stine, J. G., Brenner, M. J. & Pandian, V., Jan 2026, In: Journal of Clinical Medicine. 15, 1, 225.Research output: Contribution to journal › Review article › peer-review
Open Access -
Gastrointestinal Perforations During Endoscopy: Recognition and Management
Moyer, M. T., Rodgers, B., Brahmbhatt, R. & Deutsch, M., Apr 2026, In: Gastrointestinal Endoscopy Clinics of North America. 36, 2, p. 279-299 21 p.Research output: Contribution to journal › Article › peer-review
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Histopathology and characteristics of colorectal polyps in a Sub-Saharan setting-implications for local colon cancer screening
Duah, A., Amakye, D., Ssentongo, P. & Clarke, K., 2026, In: Expert Review of Gastroenterology and Hepatology. 20, 1, p. 57-62 6 p.Research output: Contribution to journal › Article › peer-review
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Mechanisms of the inflammatory activation of mesenchymal cells in ulcerative colitis
Pinchuk, I. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
3/1/26 → 12/31/26
Project: Research project
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Pennsylvania Colorectal Cancer Alliance to Reduce Mortality and Enhance Screening (PA-CARES)
Randal, F. (PI), Kim, K. (CoI), Hohl, R. (CoI), Ruffin, M. (CoI), Calo, W. (CoI), Maranki, J. (CoI), Felix, T. (CoI), Leibovitz, D. (CoI) & Lozano, P. (CoI)
Centers for Disease Control and Prevention
8/30/25 → 8/29/30
Project: Research project
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Intestinal epithelial paracellular permeability and immune tolerance
Nighot, P. (PI)
National Institute of Allergy and Infectious Diseases
2/1/25 → 1/31/27
Project: Research project
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Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.
Deretic, V. V. P. (PI), Cannon, J. L. (CoPI), Castillo, E. F. (CoPI), Pu, J. J. (CoPI), Cassano, J. J. J. (CoPI), Liu, M. (CoPI), Mandell, M. A. (CoPI), Mccormick, M. (CoPI), Mellios, N. (CoPI), Rosas Lemus, M. M. (CoPI), Nighot, P. (CoPI), Prossnitz, E. R. (CoPI), Balne, P. P. K. (CoPI), Sklar, L. A. (CoPI), Endicott, S. J. S. (CoPI), Kim, T.-H. T. (CoPI) & Yang, X. (CoPI)
9/1/17 → 8/31/26
Project: Research project
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Autophagy and Hepatic Stellate cells activation
Nighot, P. (PI)
National Institute of Allergy and Infectious Diseases
6/1/24 → 4/30/26
Project: Research project
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The Role of the Voltage-Gated Sodium Channel, NaV1.8, in Silent Inflammatory Bowel Disease
Coates, M. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
4/10/20 → 1/31/24
Project: Research project
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Intestinal Barrier, Probiotic Bacteria, and the Gut-Liver Axis
Ma, T. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
3/18/19 → 12/31/23
Project: Research project
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CHARM 2: Chemotherapy for ablation and resolution of mucinous pancreatic cysts: a prospective, randomized, double-blind, multi-center clinical trial
Moyer, M. (PI) & DEWITT, J. M. (CoPI)
8/1/18 → 7/31/23
Project: Research project
Activities
- 4 Invited talk
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Nonalcoholic fatty liver disease and Exercise is Medicine
Stine, J. (Speaker)
2020 → …Activity: Talk types › Invited talk
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Frailty in ICU- implications for transplant candidacy
Stine, J. (Speaker)
May 2019 → …Activity: Talk types › Invited talk
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Eosinophilic esophagitis: Pathogenesis and management
Ghaffari, G. (Speaker)
Apr 2019Activity: Talk types › Invited talk
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Metabolic Syndrome After Transplantation
Stine, J. (Speaker)
2018 → …Activity: Talk types › Invited talk
Prizes
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Career Citation Milestone Award - D (500) Club
Broach, J. (Recipient), Coates, M. (Recipient), Duffy, C. (Recipient), Gardner, A. (Recipient), Gill, D. (Recipient), Helm, K. (Recipient), Kimball, S. (Recipient), Leslie, D. (Recipient), Lipton, A. (Recipient), Ma, T. (Recipient), Naccarelli, G. (Recipient), Schmitz, K. (Recipient), Siedlecki, C. (Recipient), Stoute, J. (Recipient), Tombran-Tink, J. (Recipient) & Wang, H.-G. (Recipient), 2020
Prize
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Dean's Award for Excellence in Teaching
Aprile, B. (Recipient), Bezinover, D. (Recipient), Blackall, G. (Recipient), Booth, J. (Recipient), Buchkovich, N. (Recipient), Budde, A. (Recipient), Burns, A. (Recipient), Cartee, T. (Recipient), Chu, D. C. (Recipient), Cilley, R. (Recipient), Crook, T. (Recipient), Dalke, K. (Recipient), Dambro, A. (Recipient), De Jesus, S. (Recipient), Demetriou, T. (Recipient), DeWaters, A. (Recipient), Duca, N. (Recipient), Evey, L. (Recipient), Frauenhoffer, E. (Recipient), Garner, M. (Recipient), Glass, K. (Recipient), Goyal, N. (Recipient), Grine, K. (Recipient), Habib, S. (Recipient), Irby, R. (Recipient), Jones, E. (Recipient), June, R. (Recipient), Karamchandani, K. (Recipient), Karpa, K. (Recipient), Kasmire, K. (Recipient), Katzman, M. (Recipient), Kavanagh, R. (Recipient), Kees-Folts, D. (Recipient), Kesterson, J. (Recipient), Sciacca Kirby, J. (Recipient), Kresch, M. (Recipient), Lankford, E. (Recipient), McDonald, A. (Recipient), Miller, R. (Recipient), Moldovan, G.-L. (Recipient), Myler, C. (Recipient), Nelson, A. (Recipient), Neutze, J. (Recipient), Newell, J. (Recipient), Norbury, C. (Recipient), O'Hara, C. (Recipient), Palmer, T. (Recipient), Pantanelli, S. (Recipient), Pichardo-Lowden, A. (Recipient), Po, W. (Recipient), Radico, J. (Recipient), Radtka, J. (Recipient), Razeghi, S. (Recipient), Rodgers, R. (Recipient), Romanoski, N. (Recipient), Samson, T. (Recipient), Shantz, L. (Recipient), Smith, B. (Recipient), Stephens, M. (Recipient) & Wang, M. (Recipient), 2019
Prize
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Dean's Award for Excellence in Teaching
Aber, R. (Recipient), Anderson, A. (Recipient), Aynardi, M. (Recipient), Browning, K. (Recipient), Chen, M. (Recipient), Chu, D. C. (Recipient), Cios, T. (Recipient), Cruz, A. (Recipient), Cruz, J. (Recipient), Dalal, P. (Recipient), Dambro, A. (Recipient), Disori, K. (Recipient), Dodge, D. (Recipient), Duda, L. (Recipient), Evey, L. (Recipient), Fotos, J. (Recipient), Fredrick, N. B. (Recipient), Freeman, M. (Recipient), Gordin, V. (Recipient), Graziane, J. (Recipient), Hempel, E. (Recipient), Hennrikus, E. (Recipient), Horwitz, A. (Recipient), Izer, J. (Recipient), Jhaveri, P. (Recipient), Kalantari, A. (Recipient), Karpa, K. (Recipient), Kaur, G. (Recipient), Keil, R. (Recipient), Khalid, M. F. (Recipient), Kimball, S. (Recipient), Knoedler, J. (Recipient), LaClair, M. (Recipient), Lam, C. (Recipient), LaRegina, C. (Recipient), Lighthall, J. (Recipient), Mailman, R. (Recipient), McCormick, J. (Recipient), McGinn, J. (Recipient), McShane, M. (Recipient), Millard, R. (Recipient), Myers, A. (Recipient), Nasir, M. (Recipient), Oh, J. (Recipient), Pathare, A. (Recipient), Peterson, B. (Recipient), Potochny, J. (Recipient), Roberts, S. M. (Recipient), Romanoski, N. (Recipient), Ross, S. (Recipient), Rudnitsky, G. (Recipient), Schade, M. (Recipient), Simmons, Z. (Recipient), Smink, G. (Recipient), Stella, S. (Recipient), Stephens, M. (Recipient), Surapaneni, S. (Recipient), Verbeek, T. (Recipient), Waning, D. (Recipient), Williams, E. (Recipient), Williams, D. (Recipient), Wilson, M. E. (Recipient), Zaorsky, N. (Recipient) & Lutzkanin, A. (Recipient), 2020
Prize
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Dean's Award for Excellence in Teaching
Parent, L. (Recipient), Reid, J. S. (Recipient), Krok, K. (Recipient), Lubin, J. (Recipient), Acharya, J. (Recipient) & Felix, T. (Recipient), 2014
Prize
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Dean's Award for Excellence in Teaching
Hussein, R. (Recipient), Stredny, E. (Recipient), Whitley, M. (Recipient), Mnatsakanyan, N. (Recipient), Raimundo, N. (Recipient), Zarnescu, D. (Recipient), Adams, N. (Recipient), Lanza, M. (Recipient), Kowalczyk, A. (Recipient), Travelute, C. (Recipient), Marco, C. (Recipient), Tondt, J. (Recipient), Anderson, A. (Recipient), Heron, C. (Recipient), Newman, R. (Recipient), Richard, D. (Recipient), Scartozzi, C. (Recipient), Dellasega, C. (Recipient), Akhtar, N. (Recipient), Albano-Aluquin, S. (Recipient), Chisty, A. (Recipient), Crook, T. (Recipient), Federici, E. H. (Recipient), Ingram, D. (Recipient), Lakshmanan, P. (Recipient), Mathew, A. (Recipient), Narayana, S. (Recipient), Prokop, A. (Recipient), Razjouyan, H. (Recipient), Tariq, A. (Recipient), Thompson, B. (Recipient), Thompson, E. (Recipient), Trivedi, N. (Recipient), Van Scoy, L. (Recipient), Wong, J. (Recipient), Allie, S. R. (Recipient), Browning, K. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Mamarabadi, M. (Recipient), Shankar, L. (Recipient), Bowie, E. (Recipient), Petfield, J. (Recipient), Whitaker, M. (Recipient), Aynardi, J. (Recipient), Allen, N. (Recipient), Cunningham, B. (Recipient), Gandhi, C. (Recipient), Jairath, B. (Recipient), Lutzkanin, K. M. (Recipient), Kerris, E. (Recipient), Nelson, A. (Recipient), Shook, J. (Recipient), Proctor, E. A. (Recipient), Raup-Konsavage, W. (Recipient), Romanoski, N. (Recipient), Graziane, J. (Recipient), Llorente, A. (Recipient), Nutting, S. (Recipient), Pinto, C. (Recipient), Yingst, J. (Recipient), Zhou, S. (Recipient), Mahase, S. (Recipient), Brian, P. (Recipient), Goldman, E. (Recipient), Maffie, J. (Recipient), Brahmbhatt, R. (Recipient), Fahy, A. (Recipient), Gish, J. (Recipient), Reed, M. F. (Recipient) & Tomasko, J. (Recipient), 2024
Prize
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Dean's Award for Excellence in Teaching
McAlevy, M. (Recipient), Bonavia, A. (Recipient), Malhotra, A. (Recipient), Weller, G. E. (Recipient), Waning, D. (Recipient), Lanza, M. (Recipient), Ken, K. (Recipient), McCarver, S. (Recipient), Glasser, J. (Recipient), Schooler, J. (Recipient), Lewis, S. (Recipient), Onks, C. (Recipient), Rao, R. (Recipient), Nickolich, S. (Recipient), Helm, L. (Recipient), Critchfield, L. (Recipient), Myers, K. (Recipient), Green, M. (Recipient), Songdej, N. (Recipient), Narayana, S. (Recipient), Razjouyan, H. (Recipient), Duca, N. (Recipient), Casas, R. (Recipient), Cooper, J. (Recipient), Wright, R. (Recipient), Karasinski, A. (Recipient), Probolus, J. A. (Recipient), Madara, J. (Recipient), Guck, D. (Recipient), Ingram, D. (Recipient), De Obaldia, A. (Recipient), Hussein, R. (Recipient), McGillen, B. (Recipient), Chapman, T. (Recipient), Munyon, R. (Recipient), Kinard, S. R. (Recipient), Banks, S. (Recipient), Genao, I. (Recipient), McShane, M. (Recipient), Allie, S. R. (Recipient), Silberman, Y. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Grogan, J. (Recipient), Nguyen, J. (Recipient), Donato, H. (Recipient), Fox, E. (Recipient), Gniady, J. (Recipient), Oladipo, O. (Recipient), Abendroth, C. (Recipient), Keefer, L. (Recipient), Massare, B. (Recipient), Undar, A. (Recipient), Mondal, P. (Recipient), Mainali, G. (Recipient), Jhaveri, P. (Recipient), Freiberg, A. (Recipient), Levenson, R. (Recipient), Mailman, R. (Recipient), Boodoo, R. (Recipient), Francis, A. (Recipient), Hameed, U. (Recipient), Yadav, S. (Recipient), Calo, W. (Recipient), Pinto, C. (Recipient), Cooper, A. (Recipient), Kulaylat, A. (Recipient), Scow, J. (Recipient), Roberts, J. (Recipient), Winder, J. (Recipient), Aminsharifi, A. (Recipient), Adams, N. (Recipient) & van Riggelen, J. (Recipient), 2023
Prize
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Dean's Award for Excellence in Teaching
Aprile, B. (Recipient), Aumiller, B. B. (Recipient), Berkey, F. (Recipient), Bonavia, A. (Recipient), Booth, J. (Recipient), Brennan, K. (Recipient), Browning, K. (Recipient), Buchkovich, N. (Recipient), Butt, F. K. (Recipient), Carrel, L. (Recipient), Choe, A. (Recipient), Clarke, S. (Recipient), Coleman, M. (Recipient), Dalke, K. (Recipient), Devaraj, T. (Recipient), Duryea, S. (Recipient), Enama, J. (Recipient), Evey, L. (Recipient), Finch, E. (Recipient), Fischer, M. (Recipient), Gallo, R. (Recipient), Gavigan, P. (Recipient), Ghaffari, G. (Recipient), Go, P. (Recipient), Grana, J. (Recipient), Greensmith, J. (Recipient), Grogan, J. (Recipient), Hajnal, A. (Recipient), Helm, M. (Recipient), Hempel, N. (Recipient), Imamura, F. (Recipient), Jain, R. (Recipient), Jeganathan, N. (Recipient), Kelle, A. (Recipient), Kumar, A. (Recipient), Kwun, H. J. (Recipient), Lang, C. (Recipient), Lutzkanin, A. (Recipient), Martin, K. (Recipient), McGarrity, T. (Recipient), McHale, K. (Recipient), McLaughlin, P. (Recipient), Mormando, C. (Recipient), Nguyen, J. (Recipient), Nickolich, M. (Recipient), Ouyang, T. (Recipient), Pachuski, J. (Recipient), Polimera, H. (Recipient), Potochny, E. (Recipient), Rakszawski, K. L. (Recipient), Reyes, L. (Recipient), Sankoorikal, B.-J. (Recipient), Shantz, L. (Recipient), Singh, M. (Recipient), Songdej, N. (Recipient), Spotts, R. (Recipient), Swigart, A. (Recipient), Varner, M. (Recipient), Verma, N. (Recipient), Walter, V. (Recipient), Wang, C.-Y. (Recipient), Warfield, D. (Recipient), Wilson, M. N. (Recipient) & Hussein, R. (Recipient), 2021
Prize
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Distinguished Educator Award
Caputo, G. (Recipient), Jeffries, G. (Recipient) & Keil, R. (Recipient), 2006
Prize
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Distinguished Educator Award
Behura, C. (Recipient), DeWaters, A. (Recipient), George, M. (Recipient) & Williams, E. (Recipient), 2024
Prize