Division of Reproductive Endocrinology & Infertility

Websitehttps://med.psu.edu/reproductive-endocrinology-infertility

Postal addressShow on map
United States

Samantha Butts, MD, MSCE
- Department of Obstetrics and Gynecology - Professor and Vice Chair of Quality
- Division of Reproductive Endocrinology & Infertility - Chief
Person: Academic
20032026
Olumayowa Dayo, MD, MPH
- Department of Obstetrics and Gynecology - Assistant Professor
- Division of Reproductive Endocrinology & Infertility
Person: Academic
20132026
Stephanie Estes, MD
- Department of Obstetrics and Gynecology - Professor
- Division of Reproductive Endocrinology & Infertility
Person: Academic
20032026
Richard Legro, MD
- Department of Obstetrics and Gynecology - Professor and University Chair
- Division of Reproductive Endocrinology & Infertility
- Department of Public Health Sciences - Professor
- Penn State Clinical and Translational Science Institute (CTSI)
Person: Academic
19922026
Yifei Liu, PhD
- Department of Obstetrics and Gynecology - Assistant Professor
- Division of Reproductive Endocrinology & Infertility
Person: Academic
20032025

55831 Citations
110 h-index
473 Article
65 Review article
48 Editorial
30 Comment/debate
More

Association Between Prepregnancy Blood Pressure and Reproductive Outcomes of In Vitro Fertilization
Fang, Y., Wang, Z., Li, Y., Shang, X., Xu, D., Zhao, L., Niu, Y., Zou, J., Zhao, D., Ouyang, G., Xiao, H., Li, N., Yu, Y., Liu, Y., Liu, C., Wang, Y., Qin, Y., Zhang, H., Legro, R. S. & Wei, D. & 1 others, Chen, Z. J., 2026, In: Hypertension. Publish Ahead of Print, p. 1-10 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Feasibility and effectiveness of a health educational intervention to improve navigation of health insurance benefits for in vitro fertilization: a randomized controlled trial
Dayo, O., Kaiser, B. N., Flores Ortega, R. E., Turcotte, V., Reyes, B., Bisarya, N., Kwan, B., Aarons, G. A., McMenamin, S. B., Su, H. I. & Romero, S. A. D., Feb 2026, In: Journal of Assisted Reproduction and Genetics. 43, 2, p. 581-594 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Fitbit data in tracking exercise adherence in a clinical trial
Hu, Y., Deng, A., Jiang, Y., Huang, H., Thomas, T., Hansen, K. R., Steiner, A. Z., Coutifaris, C., Cedars, M. I., Eisenberg, E., Santoro, N., Diamond, M. P., Legro, R. S. & Zhang, H., 2026, In: Statistics and its Interface. 19, 1, p. 101-112 12 p.
Research output: Contribution to journal › Article › peer-review
Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: Multicentre, randomised clinical trial
Wei, D., Qin, Y., Sun, Y., Yan, J., Zhao, H., Guan, Y., Tan, J., Guo, T., Wang, Z., Gong, F., Hao, C., Ma, X., Zhang, C., Zhang, A., Geng, L., Sun, M., Li, X., Ling, X., Lu, Q. & Bao, H. & 61 others, Chao, L., Huang, W., Shi, Q., Zhao, J., Lu, Y., Wu, S., Zhang, S., Wang, J., Guo, M., Sun, X., Ma, Y., Wu, Q., Li, Y., Ou, X., Fang, Z., Chen, J., Hao, G., Zhang, H., Legro, R. S., Chen, Z. J., Ding, L., Liu, H., Ma, Z., Jiang, J., Feng, Z., Guo, Q., Sheng, Y., Wu, K., Ma, S., Li, C., Liu, P., Lv, J., Han, X., Meng, Y., Li, Y., Jiao, X., Zhao, S., Shang, X., Zhao, L., He, Y., Zhang, W., Gao, S., Tang, S., Li, S., Cui, T., Zhang, S., Xu, B., Xu, J., Chen, M., Pan, Y., Zhang, L., Dai, C., Xiao, L., Zhu, H., Hu, M., Yuan, Y., Li, H., Zhu, J., Li, M., Zhao, J. & Yuan, R., Jan 21 2026, In: BMJ. 392, e087045.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Link opens in a new tab Scopus citations
Rethinking do no harm
Parry, J. P., Estes, S. & Anderson, T. L., 2026, (Accepted/In press) In: Fertility and sterility.
Research output: Contribution to journal › Editorial › peer-review
Total Testosterone Measured by Liquid Chromatograph-Tandem Mass Spectrometry Refines Diagnosis of Biochemical Hyperandrogenism and Better Identifies Subgroup at Genuine Risk of Adverse Fertility Outcomes in Women With Polycystic Ovary Syndrome
PCOSAct Study Group, Jan 1 2026, In: Reproductive Medicine and Biology. 25, 1, e70013.
Research output: Contribution to journal › Article › peer-review

Open Access
Vitamin D binding protein and reproductive outcomes
Tien-Lynn Lee, I., Hoofnagle, A. N., Legro, R. S., Diamond, M. P., Koelper, N., Krawetz, S. A. & Butts, S. F., Apr 2026, In: Fertility and sterility. 125, 4, p. 698-707 10 p.
Research output: Contribution to journal › Article › peer-review
Correction to: Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes (Nature Medicine, (2025), 31, 12, (4214-4224), 10.1038/s41591-025-03984-1)
China Women’s Reproductive Metabolic Network, Dec 2025, In: Nature Medicine. 31, 12, p. 4314 1 p.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes
China Women’s Reproductive Metabolic Network, Dec 2025, In: Nature Medicine. 31, 12, p. 4214-4224 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Link opens in a new tab Scopus citations
Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study
Suturina, L., Lizneva, D., Lazareva, L., Danusevich, I., Nadeliaeva, I., Belenkaya, L., Atalyan, A., Belskikh, A., Bairova, T., Sholokhov, L., Rashidova, M., Krusko, O., Darzhaev, Z., Rinchindorzhieva, M., Malanova, A., Alekseeva, L., Sharifulin, E., Kuzmin, M., Igumnov, I. & Babaeva, N. & 20 others, Tyumentseva, D., Grebenkina, L., Kurashova, N., Darenskaya, M., Belyaeva, E., Belkova, N., Egorova, I., Salimova, M., Damdinova, L., Sambyalova, A., Radnaeva, E., Dyachenko, O., Antsupova, K., Trofimova, T., Khomyakova, A., Ievleva, K., Stanczyk, F. Z., Legro, R. S., Yildiz, B. O. & Azziz, R., Jan 1 2025, In: Journal of Clinical Endocrinology and Metabolism. 110, 1, p. e32-e43
Research output: Contribution to journal › Article › peer-review
8 Link opens in a new tab Scopus citations

2 Active
22 Finished

Early Intervention to Promote Cardiovascular Health of Mothers and Children in Northern Appalachia
Paul, I. (PI) & Legro, R. (CoPI)
National Heart, Lung, and Blood Institute
7/1/24 → 6/30/29
Project: Research project
Penn Center for Study of Epigenetics in Reproduction
Bartolomei, M. S. (PI), Berger, S. L. (CoPI), Butts, S. (CoPI), Coutifaris, C. (CoPI), Mainigi, M. A. (CoPI), Shuda, J. (CoPI), Senapati, S. (CoPI) & Wang, P. J. (CoPI)
4/1/14 → 5/31/26
Project: Research project
Inositol Supplementation to Treat Reproductive and Metabolic Dysfunction in Polycystic Ovary Syndrome: A Double Blind RCT (INSUPP-PCOS)
Legro, R. (PI)
National Center for Complementary and Integrative Health
9/1/18 → 8/31/25
Project: Research project
PILOT: EFFECT OF MATERNAL EXPOSURES ON FETAL GROWTH, METABOLISM, AND DEVELOPMENT
Butts, S. (PI)
National Institute of Child Health and Human Development
4/1/14 → 3/31/16
Project: Research project
Annual Meeting of the Androgen Excess Society
Legro, R. (PI)
9/8/13 → 8/31/16
Project: Research project
Penn Center for Study of Epigenetics in Reproduction
Bartolomei, M. S. (PI), Berger, S. L. (CoPI), Butts, S. (CoPI), Coutifaris, C. (CoPI), Meyer, R. G. (CoPI) & Shuda, J. (CoPI)
5/1/11 → 3/31/13
Project: Research project
PILOT: EFFECT OF MATERNAL EXPOSERS ON PREDICTORS OF METABOLISM, GROWTH&REPRODUC
Butts, S. (PI)
National Institute of Child Health and Human Development
5/1/11 → 3/31/14
Project: Research project
Hyperandrogenism and Insulin Resistance in the Ontogeny of PCOS
Legro, R. (PI)
National Institute of Child Health and Human Development
4/1/09 → 3/31/13
Project: Research project
PHENOTYPING KINDREDS OF FAMILIAL PCOS
Legro, R. (PI)
National Center for Research Resources
4/1/09 → 3/31/10
Project: Research project
Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
Legro, R. (PI) & Legro, R. S. (CoPI)
National Institute of Child Health and Human Development
6/2/08 → 3/31/14
Project: Research project

Career Citation Milestone Award - D (500) Club
Barber, A. (Recipient), Belani, C. (Recipient), Bixler, E. (Recipient), Eslinger, P. (Recipient), Imamura, Y. (Recipient), Legro, R. (Recipient), Mailman, R. (Recipient), Schiff, S. (Recipient), Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2019
Prize
Career Citation Milestone Award - D (500) Club
Chau, V. (Recipient), Chiang, H.-L. (Recipient), Eisen, H. (Recipient), Francis, A. (Recipient), Legro, R. (Recipient), Machtay, M. (Recipient), Norgren, R. (Recipient), Peterson, B. (Recipient) & Zelis, R. (Recipient), 2021
Prize
Career Research Excellence Award
Legro, R. (Recipient), 2020
Prize

Division of Reproductive Endocrinology & Infertility

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Samantha Butts, MD, MSCE

Olumayowa Dayo, MD, MPH

Stephanie Estes, MD

Richard Legro, MD

Yifei Liu, PhD

Association Between Prepregnancy Blood Pressure and Reproductive Outcomes of In Vitro Fertilization

Feasibility and effectiveness of a health educational intervention to improve navigation of health insurance benefits for in vitro fertilization: a randomized controlled trial

Fitbit data in tracking exercise adherence in a clinical trial

Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: Multicentre, randomised clinical trial

Rethinking do no harm

Total Testosterone Measured by Liquid Chromatograph-Tandem Mass Spectrometry Refines Diagnosis of Biochemical Hyperandrogenism and Better Identifies Subgroup at Genuine Risk of Adverse Fertility Outcomes in Women With Polycystic Ovary Syndrome

Vitamin D binding protein and reproductive outcomes

Correction to: Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes (Nature Medicine, (2025), 31, 12, (4214-4224), 10.1038/s41591-025-03984-1)

Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes

Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study

Early Intervention to Promote Cardiovascular Health of Mothers and Children in Northern Appalachia

Penn Center for Study of Epigenetics in Reproduction

Inositol Supplementation to Treat Reproductive and Metabolic Dysfunction in Polycystic Ovary Syndrome: A Double Blind RCT (INSUPP-PCOS)

PILOT: EFFECT OF MATERNAL EXPOSURES ON FETAL GROWTH, METABOLISM, AND DEVELOPMENT

Annual Meeting of the Androgen Excess Society

Penn Center for Study of Epigenetics in Reproduction

PILOT: EFFECT OF MATERNAL EXPOSERS ON PREDICTORS OF METABOLISM, GROWTH&REPRODUC

Hyperandrogenism and Insulin Resistance in the Ontogeny of PCOS

PHENOTYPING KINDREDS OF FAMILIAL PCOS

Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women

Career Citation Milestone Award - D (500) Club

Career Citation Milestone Award - D (500) Club

Career Research Excellence Award

Division of Reproductive Endocrinology & Infertility

Fingerprint

Collaborations and top research areas from the last five years

Profiles

Research output

Projects

Prizes