Organization profile
Organization profile
Flow cytometry is a means of identifying and measuring certain physical and chemical characteristics of cells or particles as they travel in suspension one by one past a sensing point. The flow cytometer is able to "look" at thousands of cells or particles per second and perform and record many simultaneous measurements for each cell or particle.
About the Flow Cytometry Core
The mission of the Flow Cytometry Core at Penn State College of Medicine is to facilitate cutting-edge research by providing this state-of-the-art fluorescence-activated cell sorting and analytical services at reasonable hourly rates. To achieve these goals, the facility provides three full-time staff and a faculty director to help investigators with all aspects of data collection including experiment design.
RRID:SRC_021134
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Collaborations and top research areas from the last five years
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Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates
White, J., Choi, Y. B., Zhang, J., Vo, M. T., He, C., Shaikh, K. & Harhaj, E. W., 2025, In: Autophagy. 21, 1, p. 160-177 18 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations -
Activity of DNA polymerase κ across the genome in human fibroblasts
Torres, M. C., Rebok, A., Sun, D. & Spratt, T. E., Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 28, e2403130121.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes
Paudel, B. B., Tan, S. F., Fox, T. E., Ung, J., Golla, U., Shaw, J. J. P., Dunton, W., Lee, I., Fares, W. A., Patel, S., Sharma, A., Viny, A. D., Barth, B. M., Tallman, M. S., Cabot, M., Garrett-Bakelman, F. E., Levine, R. L., Kester, M., Feith, D. J. & Claxton, D. & 2 others, , Mar 12 2024, In: Blood Advances. 8, 5, p. 1137-1142 6 p.Research output: Contribution to journal › Letter › peer-review
Open Access7 Link opens in a new tab Scopus citations -
AUTS2 disruption causes neuronal differentiation defects in human cerebral organoids through hyperactivation of the WNT/β-catenin pathway
Geng, Z., Tai, Y. T., Wang, Q. & Gao, Z., Dec 2024, In: Scientific reports. 14, 1, 19522.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Brincidofovir inhibits polyomavirus infection in vivo
Butic, A. B., Katz, Z. E., Jin, G., Fukushima, K., Hazama, M., Lukacher, A. E. & Lauver, M. D., Aug 1 2024, In: mBio. 15, 8Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Hattori, T., Fundora, K. A., Hamamoto, K., Opozda, D. M., Liang, X., Liu, X., Zhang, J., Uzun, Y., Takahashi, Y. & Wang, H. G., 2024, In: Autophagy. 20, 2, p. 349-364 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma
Lu, T., Yee, P. P., Chih, S. Y., Tang, M., Chen, H., Aregawi, D. G., Glantz, M. J., Zacharia, B. E., Wang, H.-G. & Li, W., Jul 1 2024, In: EMBO Journal. 43, 13, p. 2582-2605 24 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Scopus citations -
Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines
Karelia, D., Corey, Z., Wang, H., Raup-Konsavage, W. M., Vrana, K. E., Lü, J. & Jiang, C., Apr 1 2024, In: Cannabis and Cannabinoid Research. 9, 2, p. 523-536 14 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins
Seo, T., Lowery, A. M., Xu, H., Giang, W., Troyanovsky, S. M., Vincent, P. A. & Kowalczyk, A. P., May 2024, In: PloS one. 19, 5 May, e0290485.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis
Khatib, J. B., Dhoonmoon, A., Moldovan, G. L. & Nicolae, C. M., Dec 2024, In: Nature communications. 15, 1, 6197.Research output: Contribution to journal › Article › peer-review
Open Access13 Link opens in a new tab Scopus citations
Equipment
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COM-FCCS-10-color FACSCanto
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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COM-FCCS-16-color BD LSR Fortessa
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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COM-FCCS-17-color BD FACS Symphony
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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COM-FCCS-23-color BD FACS Symphony
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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COM-FCCS-9-color BD FACS Melody cell sorter
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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COM-FCCS-BD Rhapsody single cell capture system
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Equipment
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Flow Cytometry and Cell Sorting
Flow Cytometry and Cell Sorting Biomedical Core FacilityEquipment/facility: Facility