Projects per year
Personal profile
Research interests
The lab of Drs. Amanda Nelson and Diane Thiboutot is focused on understanding the skin-specific and immune mechanisms underlying inflammatory skin diseases associated with sebaceous glands and hair follicles, such as acne vulgaris and hidradenitis suppurativa. The lab is also interested in the role of innate immunity, specifically TLR signaling pathways, in normal keratinocytes and in non-melanoma skin cancer. Another focus of the laboratory is understanding the relationship between the skin microbiome, host immune response and changes that occur with the development of skin diseases or the treatment of skin diseases. Translational studies use cell culture, mouse models and samples from patients. The group uses its varied expertise in cell and molecular biology approaches and human subjects research to investigate the pathogenesis of skin diseases.
Teaching and educational interests
Dr. Amanda Nelson is a faculty member in the Biomedical Sciences (BMS) Graduate Program and the MD/PhD Medical Scientist Training Program at Penn State College of Medicine.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Johns Hopkins University School of Medicine
2010 → 2013
Postdoctoral Fellowship, Penn State College of Medicine
2007 → 2010
PhD, Penn State College of Medicine
… → 2007
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 3 Finished
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Adherens Junction dysfunction in Hidradenitis Suppurativa
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/23
Project: Research project
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Defining the role of Toll-like receptor 3 in skin homeostasis, injury and neoplasia
National Institute of Arthritis and Musculoskeletal and Skin Diseases
4/1/16 → 3/31/21
Project: Research project
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Cytokine Regulation of Wound Induced Skin Regeneration
National Institute of Arthritis and Musculoskeletal and Skin Diseases
12/7/12 → 12/6/13
Project: Research project
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Evolution of the facial skin microbiome during puberty in normal and acne skin
Schneider, A. M., Nolan, Z. T., Banerjee, K., Paine, A. R., Cong, Z., Gettle, S. L., Longenecker, A. L., Zhan, X., Agak, G. W. & Nelson, A. M., Jan 2023, In: Journal of the European Academy of Dermatology and Venereology. 37, 1, p. 166-175 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
Oparaugo, N. C., Ouyang, K., Nguyen, N. P. N., Nelson, A. M. & Agak, G. W., Jan 2023, In: International journal of molecular sciences. 24, 2, 1527.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies
Schell, S. L., Cong, Z., Sennett, M. L., Gettle, S. L., Longenecker, A. L., Goldberg, S. R., Kirby, J. S., Helm, M. F. & Nelson, A. M., Mar 2023, In: British Journal of Dermatology. 188, 3, p. 407-419 13 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Patients with hidradenitis suppurativa have a higher rate of postoperative infections
Jefferson, I. S., Fritsche, M., Maczuga, S. A., Allen, S. R., Nelson, A. & Kirby, J. S., Mar 2023, In: Journal of the American Academy of Dermatology. 88, 3, p. 705-708 4 p.Research output: Contribution to journal › Article › peer-review
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Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome
Nolan, Z. T., Banerjee, K., Cong, Z., Gettle, S. L., Longenecker, A. L., Kawasawa, Y. I., Zaenglein, A. L., Thiboutot, D. M., Agak, G. W., Zhan, X. & Nelson, A. M., Jul 2023, In: Experimental Dermatology. 32, 7, p. 955-964 10 p.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Dean's Award for Excellence in Teaching
Aprile, Bettina (Recipient), Bezinover, Dmitri (Recipient), Blackall, George (Recipient), Booth, Jennifer (Recipient), Buchkovich, Nicholas (Recipient), Budde, Arne (Recipient), Burns, Amy (Recipient), Cartee, Todd (Recipient), Chu, David C. (Recipient), Cilley, Robert (Recipient), Crook, Tonya (Recipient), Dalke, Katharine (Recipient), Dambro, Anthony (Recipient), De Jesus, Sol (Recipient), Demetriou, Theodore (Recipient), DeWaters, Ami (Recipient), Duca, Nicholas (Recipient), Evey, Loren (Recipient), Frauenhoffer, Elizabeth (Recipient), Garner, Matthew (Recipient), Glass, Kristen (Recipient), Goyal, Neerav (Recipient), Grine, Kristen (Recipient), Habib, Sabeen (Recipient), Irby, Rosalyn (Recipient), Jones, Edward (Recipient), June, Rayford (Recipient), Karamchandani, Kunal (Recipient), Karpa, Kelly (Recipient), Kasmire, Kathryn (Recipient), Katzman, Michael (Recipient), Kavanagh, Robert (Recipient), Kees-Folts, Deborah (Recipient), Kesterson, Joshua (Recipient), Sciacca Kirby, Joslyn (Recipient), Kresch, Mitchell (Recipient), Lankford, Edward (Recipient), McDonald, Alicia (Recipient), Miller, Ronald (Recipient), Moldovan, George-Lucian (Recipient), Myler, Conrad (Recipient), Nelson, Amanda (Recipient), Neutze, Janet (Recipient), Newell, Jordan (Recipient), Norbury, Christopher (Recipient), O'Hara, Christopher (Recipient), Palmer, Timothy (Recipient), Pantanelli, Seth (Recipient), Pichardo-Lowden, Ariana (Recipient), Po, Wilson (Recipient), Radico, Julie (Recipient), Radtka, John (Recipient), Razeghi, Sanam (Recipient), Rodgers, Ross (Recipient), Romanoski, Natasha (Recipient), Samson, Thomas (Recipient), Shantz, Lisa (Recipient), Smith, Brandon (Recipient), Stephens, Mark (Recipient) & Wang, Ming (Recipient), 2019
Prize