Projects per year
Personal profile
Research interests
Dr. Amy Arnold’s laboratory works on understanding how the brain controls blood pressure and energy balance. Her studies focus on how angiotensin-(1-7), a beneficial hormone of the renin angiotensin system, interacts with the brain to improve blood pressure and insulin sensitivity in integrated cardiometabolic diseases such as obesity and hypertension. These studies use a variety of approaches in mice including whole animal in vivo cardiovascular monitoring (e.g. direct arterial blood pressure and radiotelemetry), pharmacologic and spectral analysis of autonomic function and measurement of insulin action (e.g. hyperinsulinemic-euglycemic clamps, glucose and insulin tolerance testing) and energy balance (e.g. body composition and indirect calorimetry). She also has translational studies examining the effects of intravenous angiotensin-(1-7) infusion on blood pressure and flow, insulin sensitivity and energy balance in patients with obesity, hypertension and peripheral arterial disease. Specific projects ongoing in the laboratory include studying the ability of angiotensin-(1-7) to treat and prevent the development of diet-induced insulin resistance, the specific molecular mechanisms involved in these effects with a focus on adipose tissue and brain and potential gender differences.
In addition, her laboratory is interested in understanding mechanisms and optimal treatment strategies for patients with cardiovascular autonomic disorders including primary autonomic failure, Parkinson’s disease and postural tachycardia syndrome. Dr. Arnold has published several articles on therapeutic strategies to manage blood pressure and heart rate in these conditions. She has several ongoing studies including examining the profile and treatment of cognitive dysfunction in these conditions, with a focus on postural tachycardia syndrome.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Investigation, MS, Vanderbilt University
… → May 2014
Physiology and Pharmacology, PhD, Wake Forest University
… → Dec 2009
Biochemistry, BS, Pacific University
… → May 2004
External positions
Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics
Jan 1 2018 → …
Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics
2018 → …
Meeting Committee Member, American Autonomic Society
Jan 1 2017 → …
Editorial Board Member, American Journal of Hypertension
Jan 1 2017 → …
Meeting Committee Member, American Autonomic Society
2017 → …
Editorial Board Member, American Journal of Hypertension
2017 → …
Trainee Advocacy Committee Member, American Heart Association
Jan 1 2016 → …
Editorial Board Member, Physiological Genomics
Jan 1 2016 → …
Trainee Advocacy Committee Member, American Heart Association
2016 → …
Editorial Board Member, Physiological Genomics
2016 → …
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Collaborations and top research areas from the last five years
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Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
Arnold, A. (PI) & Gamboa, A. (CoPI)
National Heart, Lung, and Blood Institute
4/15/24 → 3/31/26
Project: Research project
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Angiotensin-(1-7) and Hypothalamic control of blood pressure
Arnold, A. (PI)
National Heart, Lung, and Blood Institute
4/1/21 → 3/31/24
Project: Research project
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Autonomic: Angiotensin-(1-7) Interactions in Hypertension
Arnold, A. (PI)
National Heart, Lung, and Blood Institute
6/1/16 → 5/31/20
Project: Research project
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Autonomic: Angiotensin-(1-7) Interactions in Hypertension
Arnold, A. (PI)
National Heart, Lung, and Blood Institute
11/15/14 → 3/31/16
Project: Research project
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Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension
Vernail, V. L., Lucas, L., Miller, A. J. & Arnold, A. C., Dec 2024, In: International journal of molecular sciences. 25, 24, 13320.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Ecological momentary assessment and cue-elicited drug craving as primary endpoints: study protocol for a randomized, double-blind, placebo-controlled clinical trial testing the efficacy of a GLP-1 receptor agonist in opioid use disorder
Freet, C. S., Evans, B., Brick, T. R., Deneke, E., Wasserman, E. J., Ballard, S. M., Stankoski, D. M., Kong, L., Raja-Khan, N., Nyland, J. E., Arnold, A. C., Krishnamurthy, V. B., Fernandez-Mendoza, J., Cleveland, H. H., Scioli, A. D., Molchanow, A., Messner, A. E., Ayaz, H., Grigson, P. S. & Bunce, S. C., Dec 2024, In: Addiction Science and Clinical Practice. 19, 1, 56.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Effects of cannabidiol, with and without ∆9-tetrahydrocannabinol, on anxiety-like behavior following alcohol withdrawal in mice
Melkumyan, M., Annaswamy, V. M., Evans, A. M., Showemimo, O. F., McCullers, Z. E., Sun, D., Murphy, T., Vrana, K. E., Arnold, A., Raup-Konsavage, W. M. & Silberman, Y., 2024, In: Frontiers in Neuroscience. 18, 1375440.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
HeartWare Left Ventricular Assist Device Exercise Hemodynamics With Speed Adjustment Based on Left Ventricular Filling Pressures
Ali, O., Arnold, A. C., Cysyk, J., Boehmer, J., Zhu, J., Sinoway, L. I., Eisen, H. & Weiss, W., Jun 1 2024, In: ASAIO journal (American Society for Artificial Internal Organs : 1992). 70, 6, p. e82-e88Research output: Contribution to journal › Article › peer-review
Open Access -
Hypertension disrupts the vascular clock in both sexes
Visniauskas, B., Ogola, B. O., Kilanowski-Doroh, I., Harris, N. R., Diaz, Z. T., Horton, A. C., Blessinger, S. A., McNally, A. B., Zimmerman, M. A., Arnold, A. C. & Lindsey, S. H., Oct 2024, In: American Journal of Physiology - Heart and Circulatory Physiology. 327, 4, p. H765-H777Research output: Contribution to journal › Article › peer-review
2 Scopus citations