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1976 …2023

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Personal profile

Research interests

Dr. Andrea Manni joined the faculty of Penn State College of Medicine in 1982 and has more than 200 scholarly publications. His primary research interest has been breast cancer with a focus on endocrine determinants of tumor biology, autocrine/paracrine factors mediating hormonal effects and interactions between hormones and polyamines in tumor control.

Dr. Manni’s research teams were among the first to demonstrate the potent antitumor activity of the antiestrogen Tamoxifen in women with hormone-responsive breast cancer. Recently, he has focused on breast cancer prevention through dietary manipulations with omega-3 fatty acids (n-3FA) in conjunction with antiestrogens. His most recent work has indicated that among n-3FA, docosahexaenoic acid (DHA) may be the most potent in selectively reducing breast cancer risk in obese postmenopausal women. He has lectured extensively on this topic nationally and internationally.

Throughout his career, Dr. Manni has served on research grant review committees such as NIH and Department of Defense study sections. He has been an editor of the Journal of Clinical Endocrinology and Metabolism, the premiere clinical journal of the Endocrine Society. He has also been on the editorial boards of several journals with a focus on endocrine oncology.

Teaching and educational interests

Throughout his career, Dr. Andrea Manni has taught medical students, residents and fellows both through formal lectures as well as direct supervision in the outpatient clinic and on the inpatient consult service. He has also mentored medical students and fellows in their research projects and is a member of both the Graduate Faculty Committee and Medical Student Research Committee at the College of Medicine.

Since 2003, Dr. Manni has chaired the Education Committee of Penn State Cancer Institute. In this role, he organizes several educational activities, some of which (the annual Cancer Symposium) bring internationally recognized investigators in translational cancer research to Penn State. Dr. Manni has also organized an annual public forum, Reducing Cancer in the Community, which is a well-attended outreach educational activity of Penn State Cancer Institute.

Clinical interests

Dr. Andrea Manni is a clinical endocrinologist at Penn State Health Milton S. Hershey Medical Center, and has been chief of the Division of Endocrinology, Diabetes and Metabolism in the Department of Medicine since 2003. He sees numerous patients with a wide range of endocrine disorders, both in the outpatient clinic and on the inpatient consult service. In this role, he frequently supervises trainees at different levels of education rotating in endocrinology.

Professional information

Elected member, American Society of Clinical Investigation, 1988

Subspecialty certified in Endocrinology and Metabolism, American Board of Internal Medicine, 1981

Board-certified in Internal Medicine, American Board of Internal Medicine, 1975

Member, American Federation for Clinical Research

Member, American Association for the Advancement of Science

Member, International Society for the Study of Comparative Oncology

Member, International Association for Breast Cancer Research

Member, New York Academy of Science

Member, Pennsylvania Oncological Society

Member, American Association for Cancer Research

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Endocrinology, Fellowship, Case Western Reserve University


Medicine, Residency, Case Western Reserve University


Medicine, Residency, Mount Sinai Hospital


Medicine, Internship, St. John Hospital and Medical Center


MD, University of Florence

… → 1970

External positions

Adjunct Professor, Department of Medical Science, Chungham National University

2014 → …


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