Projects per year
Personal profile
Research interests
Dr. Andrea Manni joined the faculty of Penn State College of Medicine in 1982 and has more than 200 scholarly publications. His primary research interest has been breast cancer with a focus on endocrine determinants of tumor biology, autocrine/paracrine factors mediating hormonal effects and interactions between hormones and polyamines in tumor control.
Dr. Manni’s research teams were among the first to demonstrate the potent antitumor activity of the antiestrogen Tamoxifen in women with hormone-responsive breast cancer. Recently, he has focused on breast cancer prevention through dietary manipulations with omega-3 fatty acids (n-3FA) in conjunction with antiestrogens. His most recent work has indicated that among n-3FA, docosahexaenoic acid (DHA) may be the most potent in selectively reducing breast cancer risk in obese postmenopausal women. He has lectured extensively on this topic nationally and internationally.
Throughout his career, Dr. Manni has served on research grant review committees such as NIH and Department of Defense study sections. He has been an editor of the Journal of Clinical Endocrinology and Metabolism, the premiere clinical journal of the Endocrine Society. He has also been on the editorial boards of several journals with a focus on endocrine oncology.
Teaching and educational interests
Throughout his career, Dr. Andrea Manni has taught medical students, residents and fellows both through formal lectures as well as direct supervision in the outpatient clinic and on the inpatient consult service. He has also mentored medical students and fellows in their research projects and is a member of both the Graduate Faculty Committee and Medical Student Research Committee at the College of Medicine.
Since 2003, Dr. Manni has chaired the Education Committee of Penn State Cancer Institute. In this role, he organizes several educational activities, some of which (the annual Cancer Symposium) bring internationally recognized investigators in translational cancer research to Penn State. Dr. Manni has also organized an annual public forum, Reducing Cancer in the Community, which is a well-attended outreach educational activity of Penn State Cancer Institute.
Clinical interests
Dr. Andrea Manni is a clinical endocrinologist at Penn State Health Milton S. Hershey Medical Center, and has been chief of the Division of Endocrinology, Diabetes and Metabolism in the Department of Medicine since 2003. He sees numerous patients with a wide range of endocrine disorders, both in the outpatient clinic and on the inpatient consult service. In this role, he frequently supervises trainees at different levels of education rotating in endocrinology.
Professional information
Elected member, American Society of Clinical Investigation, 1988
Subspecialty certified in Endocrinology and Metabolism, American Board of Internal Medicine, 1981
Board-certified in Internal Medicine, American Board of Internal Medicine, 1975
Member, American Federation for Clinical Research
Member, American Association for the Advancement of Science
Member, International Society for the Study of Comparative Oncology
Member, International Association for Breast Cancer Research
Member, New York Academy of Science
Member, Pennsylvania Oncological Society
Member, American Association for Cancer Research
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Endocrinology, Fellowship, Case Western Reserve University
1975 → 1977
Medicine, Residency, Case Western Reserve University
1974 → 1975
Medicine, Residency, Mount Sinai Hospital
1973 → 1974
Medicine, Internship, St. John Hospital and Medical Center
1972 → 1973
MD, University of Florence
… → 1970
External positions
Adjunct Professor, Department of Medical Science, Chungham National University
2014 → …
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Collaborations and top research areas from the last five years
Projects
- 11 Finished
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POLYAMINE INVOLVEMENT IN MAMMARY CARCINOGENESIS
Manni, A. (PI)
4/1/98 → 1/31/01
Project: Research project
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A-DIFLUOROMETHYLORNITHINE IN PATIENTS WITH ADVANCED BREAST CANCER
Shoemaker, N. J. K. (PI) & Manni, A. (PI)
National Center for Research Resources
10/1/97 → 9/30/99
Project: Research project
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USE OF RECOMBINANT HUMAN TSH IN THYROID CANCER PATIENTS
Manni, A. (PI)
National Center for Research Resources
10/1/97 → 9/30/99
Project: Research project
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General Clinical Research Center
Paz, H. H. L. (PI), Boustred, A. M. (CoPI), Ross, A. A. C. (CoPI), Barrett, A. A. M. (CoPI), Momen, A. (CoPI), Ahluwalia, N. (CoPI), Ahsan, N. (CoPI), Vgontzas, A. A. N. (CoPI), Ambrose, A. A. (CoPI), Dunaif, A. A. E. (CoPI), Ouyang, A. (CoPI), Bascom, R. (CoPI), Beard, J. L. (CoPI), Blosser, S. (CoPI), Boehmer, J. (CoPI), Parker, B. B. (CoPI), Campbell, W. W. (CoPI), Miller, C. C. K. (CoPI), Cavanagh, P. R. (CoPI), Dong, C. C. (CoPI), Ray, C. A. (CoPI), Ehmann, C. (CoPI), Flaherty, C. (CoPI), Macneill, C. (CoPI), Consevage, M. (CoPI), Corwin, E. J. (CoPI), Cronin, A. (CoPI), Chuang, C. C. H. (CoPI), Torgerson, C. C. S. (CoPI), Daley, J. C. (CoPI), Kirch, D. G. (CoPI), Conroy, D. D. E. (CoPI), Han, D. (CoPI), Proctor, D. N. (CoPI), Thiboutot, D. (CoPI), Downs, D. D. S. (CoPI), Erickson, D. D. (CoPI), Eggli, D. F. (CoPI), Ehman, C. (CoPI), Farace, E. (CoPI), Sieverling, E. (CoPI), Spiller, E. E. (CoPI), Vesell, E. S. (CoPI), Burks, E. E. (CoPI), Fitzgerald, E. E. (CoPI), Galka, E. E. (CoPI), Evans, W. J. (CoPI), Evarts, N. C. M. (CoPI), Eyster, N. M. E. (CoPI), Bixler, E. E. O. (CoPI), Susman, E. E. J. (CoPI), Farrell, P. A. (CoPI), Rosales, F. J. (CoPI), Gardner, T. W. (CoPI), Gaumond, R. (CoPI), Gordon, R. (CoPI), Granger, D. A. (CoPI), Graff, G. (CoPI), Podskalny, G. G. P. (CoPI), Hankey, P. A. (CoPI), Holman, M. J. (CoPI), Holtzclaw, B. J. (CoPI), Harvey, H. (CoPI), Paul, I. I. A. (CoPI), Gilchrist, I. (CoPI), Rodrigues, I. I. (CoPI), Trussel, J. J. (CoPI), Connor, J. J. D. (CoPI), Ulbrecht, J. (CoPI), Ramer, J. (CoPI), Luck, J. J. (CoPI), Cui, J. J. (CoPI), Floros, J. (CoPI), Jones, B. C. (CoPI), Finkelstein, J. J. (CoPI), Joshi, R. (CoPI), Muscat, J. (CoPI), Pawelczyk, J. J. A. (CoPI), Ultman, J. S. (CoPI), Smith, J. J. P. (CoPI), Florian, J. J. (CoPI), Kenney, L. W. (CoPI), Monahan, K. D. (CoPI), Khan, M. (CoPI), Kirwan, J. P. (CoPI), Koch, K. L. (CoPI), Kraemer, W. J. (CoPI), Kulin, H. E. (CoPI), Scott, K. K. (CoPI), Alexander, L. M. (CoPI), Lallos, C. (CoPI), LaNoue, K. (CoPI), Larsson, L. G. (CoPI), Lathrop, M. (CoPI), Klein, L. (CoPI), Demers, L. L. M. (CoPI), Rodichok, L. D. (CoPI), Birch, L. L. L. (CoPI), Xu, L. L. (CoPI), Baker, L. L. B. (CoPI), Lipton, A. (CoPI), Lloyd, T. (CoPI), Loomis, J. L. (CoPI), Stauffer, L. L. A. (CoPI), Thorndyke, L. E. (CoPI), Francis, L. A. (CoPI), Maclean, D. A. (CoPI), Manni, A. (CoPI), Lott, M. E. J. (CoPI), Mastro, A. M. (CoPI), Mccabe, P. (CoPI), McGarrity, T. (CoPI), Pallone, M. N. (CoPI), Miller, B. A. (CoPI), Petit, M. M. A. (CoPI), Mulfinger, L. (CoPI), Latash, M. M. L. (CoPI), Green, M. (CoPI), Pu, M. M. (CoPI), Xiong, N. N. (CoPI), Williams, N. (CoPI), Raja-Khan, N. (CoPI), Thomas, N. (CoPI), Ayannusi, O. E. (CoPI), Page, M. J. (CoPI), Mcnulty, P. P. H. (CoPI), Eslinger, P. (CoPI), Kris-Etherton, P. (CoPI), Lee, P. P. A. (CoPI), Phelps, D. (CoPI), Powers, S. K. (CoPI), Pritchard, T. C. (CoPI), Molenaar, P. P. C. (CoPI), Janicki, P. (CoPI), Yang, Q. Q. X. (CoPI), Ramirez-Zea, M. (CoPI), Singareddy, R. R. K. (CoPI), Reynolds, H. (CoPI), Miraliakbari, R. (CoPI), Legro, R. R. S. (CoPI), Cooney, R. (CoPI), Rolls, B. (CoPI), Rolls, B. J. (CoPI), Wilson, R. (CoPI), Jarvis, S. S. (CoPI), West, S. S. G. (CoPI), Shoemaker, N. J. K. (CoPI), Shoemaker, K. J. (CoPI), Leong, S. L. (CoPI), Shriver, M. (CoPI), Sinoway, L. I. (CoPI), Ettinger, S. (CoPI), Streufert, S. (CoPI), Ridout, S. S. J. (CoPI), Wilson, T. T. R. (CoPI), O'Bryan, T. A. (CoPI), Subramanian, T. (CoPI), Hartman, T. J. (CoPI), Loughran, T. T. P. (CoPI), Craig, T. (CoPI), Leuenberger, U. U. A. (CoPI), Imadojemu, V. A. (CoPI), Koltun, W. (CoPI), Davis, W. W. S. (CoPI), Watterberg, K. L. (CoPI), Flood, W. W. (CoPI), Reeves, W. C. (CoPI), Dodson, W. W. E. (CoPI), Curry, W. (CoPI), Rybka, W. B. (CoPI), Simmons, Z. (CoPI), Challis, J. J. (CoPI), Albaugh, V. L. (CoPI), Aronson, K. R. (CoPI), Belani, C. (CoPI), Betterman, K. (CoPI), Birch, L. L. (CoPI), Cavener, D. R. (CoPI), Claxton, D. (CoPI), Connor, J. (CoPI), Corwin, R. L. (CoPI), Cui, J. (CoPI), De Souza, M. J. (CoPI), Dong, C. (CoPI), Elavsky, S. (CoPI), Gao, Z. (CoPI), Giampetro, D. (CoPI), Gill, D. J. (CoPI), Goldenberg, D. N. (CoPI), Graff, G. R. (CoPI), Graham-Engeland, J. E. (CoPI), Green, M. H. (CoPI), Harvey, H. (CoPI), Huang, X. (CoPI), Kimchi, E. T. (CoPI), Koltun, W. A. (CoPI), Kris-Etherton, P. M. (CoPI), Lang, J. C. (CoPI), Latash, M. (CoPI), Lee, P. A. (CoPI), Legro, R. (CoPI), Leuenberger, U. (CoPI), Liao, D. (CoPI), Lohse, B. (CoPI), McBrier, N. M. (CoPI), Monahan, K. D. (CoPI), Paul, I. A. (CoPI), Paz, H. (CoPI), Proctor, D. N. (CoPI), Rauh, E. (CoPI), Ray, C. A. (CoPI), Rybka, W. (CoPI), Scalzi, L. (CoPI), Sciamanna, C. (CoPI), Scott, K. (CoPI), Selan, J. (CoPI), Singareddy, R. K. (CoPI), Skulas-Ray, A. C. (CoPI), Smith, J. P. (CoPI), Ulbrecht, J. S. (CoPI), Vender, R. (CoPI), Vgontzas, A. (CoPI), West, S. G. (CoPI), Demers, L. (CoPI), Dunaif, A. (CoPI) & Ultman, J. S. (CoPI)
8/15/95 → 3/31/07
Project: Research project
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Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model
Manni, A., Sun, Y. W., Schell, T. D., Lutsiv, T., Thompson, H., Chen, K. M., Aliaga, C., Zhu, J. & El-Bayoumy, K., Oct 2023, In: Pharmaceuticals. 16, 10, 1422.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Lifestyle Modifications and Breast Cancer Risk
Manni, A. & El-Bayoumy, K., Jun 2023, In: Cancers. 15, 11, 2870.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Analysis of Time to Diagnosis and Outcomes among Adults with Primary Hyperparathyroidism
Lorenz, F. J., Beauchamp-Perez, F., Manni, A., Chung, T., Goldenberg, D. & Goyal, N., Dec 27 2022, In: JAMA network open. 5, 12, p. E2248332Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Building a foundation for precision onco-nutrition: Docosahexaenoic acid and breast cancer
Thompson, H. J., Neil, E. S., McGinley, J. N., Fitzgerald, V. K., El Bayoumy, K. & Manni, A., Jan 1 2022, In: Cancers. 14, 1, 157.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
Chen, K. M., Thompson, H., Vanden-Heuvel, J. P., Sun, Y. W., Trushin, N., Aliaga, C., Gowda, K., Amin, S., Stanley, B., Manni, A. & El-Bayoumy, K., Dec 2021, In: Scientific reports. 11, 1, 410.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Prizes
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Outstanding Collaborative Research Team
El-Bayoumy, K. (Recipient), Manni, A. (Recipient), Richie, J. (Recipient), Liao, J. (Recipient), Vanden Heuvel, J. P. (Recipient), Demers, L. (Recipient), Dillard, J. (Recipient) & Rogers, C. J. (Recipient), 2016
Prize