Projects per year
Personal profile
Research interests
Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.
To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.
Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Establishing bioactive serum and toxicity levels for Nanolipolee-007
Sharma, A. (PI) & Sharma, A. (CoPI)
9/26/12 → 1/31/14
Project: Research project
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Chemopreventive Efficacy of Plumbagin in Melanoma
Sharma, A. K. (PI) & Sharma, A. (CoPI)
7/7/09 → 6/30/10
Project: Research project
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Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes
Paudel, B. B., Tan, S. F., Fox, T. E., Ung, J., Golla, U., Shaw, J. J. P., Dunton, W., Lee, I., Fares, W. A., Patel, S., Sharma, A., Viny, A. D., Barth, B. M., Tallman, M. S., Cabot, M., Garrett-Bakelman, F. E., Levine, R. L., Kester, M., Feith, D. J. & Claxton, D. & 2 others, , Mar 12 2024, In: Blood Advances. 8, 5, p. 1137-1142 6 p.Research output: Contribution to journal › Letter › peer-review
Open Access3 Scopus citations -
From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies
Golla, U., Patel, S., Shah, N., Talamo, S., Bhalodia, R., Claxton, D., Dovat, S. & Sharma, A., Oct 2024, In: Cancers. 16, 20, 3454.Research output: Contribution to journal › Review article › peer-review
Open Access -
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia
Ung, J., Tan, S. F., Fox, T. E., Shaw, J. J. P., Taori, M., Horton, B. J., Golla, U., Sharma, A., Szulc, Z. M., Wang, H.-G., Chalfant, C. E., Cabot, M. C., Claxton, D. F., Loughran, T. P. & Feith, D. J., Dec 2023, In: Cancers. 15, 24, 5866.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
Qian, F., Nettleford, S. K., Zhou, J., Arner, B. E., Hall, M. A., Sharma, A., Annageldiyev, C., Rossi, R. M., Tukaramrao, D. B., Sarkar, D., Hegde, S., Gandhi, U. H., Finch, E. R., Goodfield, L., Quickel, M. D., Claxton, D. F., Paulson, R. F. & Prabhu, K. S., Jul 25 2023, In: Cell Reports. 42, 7, 112794.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Kale, V. P., Hengst, J. A., Sharma, A. K., Golla, U., Dovat, S., Amin, S. G., Yun, J. K. & Desai, D. H., Aug 2023, In: Pharmaceuticals. 16, 8, 1060.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations