Projects per year
Personal profile
Research interests
Dr. Catharine I. Paules joined the faculty of Penn State College of Medicine in July 2018. She is a clinician-investigator with a research focus on COVID-19, emerging respiratory viruses and infections in bone marrow transplant recipients.
Dr. Paules was the site principle investigator (PI) for the NIAID-sponsored Adaptive COVID-19 treatment trial and the NIH-sponsored ACTIV-5 / Big Effect Trial (BET-B) for the Treatment of COVID-19. She is now the site PI for the NIH sponsored STRIVE trial to study strategies and treatments for patients with COVID-19 and other respiratory viruses. She is also involved in the COVID-19 Project ECHO for Nursing Homes and the NIH Recover initiative for Long COVID.
Teaching and educational interests
Dr. Paules is committed to the mentorship and teaching of medical students, residents, fellows and other trainees. She has multiple publications involving trainees and in 2021 a resident she mentored received the resident research award. Dr. Paules is also actively engaged in community education with involvement in infectious diseases educational forums and media outreach.
Clinical interests
Dr. Paules developed an infectious diseases consult service at Penn State Health for patients who have received (or are planned to receive) a bone marrow transplant. This specialty service sees patients in both the inpatient and outpatient setting. Dr. Paules is also involved in Bio-preparedness and serves as a member of Penn State Health's Special Pathogens Team. She was integral in the institution's clinical, research, and logistical responses to the COVID-19 pandemic.
Professional information
Board-certified, Internal Medicine, American Board of Internal Medicine, 2015
Board-certified, Infectious Diseases, American Board of Internal Medicine, 2016
Alpha Omega Alpha (AOA) Honor Medical Society, University of Nebraska Medical Center, 2011
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Infectious Diseases, Fellowship, National Institutes of Health
… → 2016
Internal Medicine, Residency, University of Maryland Medical Center
… → 2014
MD, University of Nebraska
… → 2011
BS, College of William and Mary
… → 2007
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Collaborations and top research areas from the last five years
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19
Young, B. E. B. E. & Paules, C.
National Research Foundation Singapore
10/1/20 → 9/30/22
Project: Research project
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Boon, L. C. L. C. & Paules, C.
National Research Foundation Singapore
3/16/20 → 3/15/22
Project: Research project
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Accelerating guideline dissemination in nursing homes during the COVID-19 pandemic: A patient-centered randomized controlled trial
Kraschnewski, J. L., Heilbrunn, E. S., Calo, W. A., Kong, L., Lehman, E., Hogentogler, E., Fisher, A., Osevala, N., Paules, C. I., Whitaker, J., Urso, J., Chamberlain, L., Suda, K. M., Stedjan, M. & McNeil, L., May 1 2023, In: Geriatric Nursing. 51, p. 439-445 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections
Sweeney, D. A., Tuyishimire, B., Ahuja, N., Beigel, J. H., Beresnev, T., Cantos, V. D., Castro, J. G., Cohen, S. H., Cross, K., Dodd, L. E., Erdmann, N., Fung, M., Ghazaryan, V., George, S. L., Grimes, K. A., Hynes, N. A., Julian, K. G., Kandiah, S., Kim, H. J., Levine, C. B., & 10 others, May 1 2023, In: Open Forum Infectious Diseases. 10, 5, ofad205.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case
Ortega-Villa, A. M., Hynes, N. A., Levine, C. B., Yang, K., Wiley, Z., Jilg, N., Wang, J., Whitaker, J. A., Colombo, C. J., Nayak, S. U., Kim, H. J., Iovine, N. M., Ince, D., Cohen, S. H., Langer, A. J., Wortham, J. M., Atmar, R. L., El Sahly, H. M., Jain, M. K., Mehta, A. K., & 22 others, Jun 1 2023, In: Open Forum Infectious Diseases. 10, 6, ofad290.Research output: Contribution to journal › Article › peer-review
Open Access -
Optimal Duration of Systemic Corticosteroids in Coronavirus Disease 2019 Treatment: A Systematic Review and Meta-analysis
Ssentongo, P., Yu, N., Voleti, N., Reddy, S., Ingram, D., Chinchilli, V. M. & Paules, C. I., Mar 1 2023, In: Open Forum Infectious Diseases. 10, 3, ofad105.Research output: Contribution to journal › Article › peer-review
Open Access -
Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
ACTT-4 Study Group, Sep 2022, In: The Lancet Respiratory Medicine. 10, 9, p. 888-899 12 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations