Projects per year
Personal profile
Research interests
Dr. Catharine I. Paules joined the faculty of Penn State College of Medicine in July 2018. She is a clinician-investigator with a research focus on COVID-19, emerging respiratory viruses and infections in bone marrow transplant recipients.
Dr. Paules was the site principle investigator (PI) for the NIAID-sponsored Adaptive COVID-19 treatment trial and the NIH-sponsored ACTIV-5 / Big Effect Trial (BET-B) for the Treatment of COVID-19. She is now the site PI for the NIH sponsored STRIVE trial to study strategies and treatments for patients with COVID-19 and other respiratory viruses. She is also involved in the COVID-19 Project ECHO for Nursing Homes and the NIH Recover initiative for Long COVID.
Teaching and educational interests
Dr. Paules is committed to the mentorship and teaching of medical students, residents, fellows and other trainees. She has multiple publications involving trainees and in 2021 a resident she mentored received the resident research award. Dr. Paules is also actively engaged in community education with involvement in infectious diseases educational forums and media outreach.
Clinical interests
Dr. Paules developed an infectious diseases consult service at Penn State Health for patients who have received (or are planned to receive) a bone marrow transplant. This specialty service sees patients in both the inpatient and outpatient setting. Dr. Paules is also involved in Bio-preparedness and serves as a member of Penn State Health's Special Pathogens Team. She was integral in the institution's clinical, research, and logistical responses to the COVID-19 pandemic.
Professional information
Board-certified, Internal Medicine, American Board of Internal Medicine, 2015
Board-certified, Infectious Diseases, American Board of Internal Medicine, 2016
Alpha Omega Alpha (AOA) Honor Medical Society, University of Nebraska Medical Center, 2011
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Infectious Diseases, Fellowship, National Institutes of Health
… → 2016
Internal Medicine, Residency, University of Maryland Medical Center
… → 2014
MD, University of Nebraska
… → 2011
BS, College of William and Mary
… → 2007
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19
Young, B. E. B. E. (PI) & Paules, C. (PI)
National Research Foundation Singapore
10/1/20 → 9/30/22
Project: Research project
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Boon, L. C. L. C. (PI) & Paules, C. (PI)
National Research Foundation Singapore
3/16/20 → 3/15/22
Project: Research project
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A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2
Paules, C. I., Wang, J., Tomashek, K. M., Bonnett, T., Singh, K., Marconi, V. C., Davey, R. T., Lye, D. C., Dodd, L. E., Yang, O. O., Benson, C. A., Deye, G. A., Doernberg, S. B., Hynes, N. A., Grossberg, R., Wolfe, C. R., Nayak, S. U., Short, W. R., Voell, J. & Potter, G. E. & 1 others, , Mar 1 2024, In: Annals of internal medicine. 177, 3, p. 343-352 10 p.Research output: Contribution to journal › Article › peer-review
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Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials
CORIMUNO-19 Collaborative Group, DisCoVeRy Study Group, ACTT-2 Study Group & ACTT-3 Study Group, Mar 2024, In: EClinicalMedicine. 69, 102472.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation
Zulch, E., Inoue, Y., Cioccio, J., Rakszawski, K., Songdej, N., Nickolich, M., Zheng, H., Naik, S., Rybka, W., Ehmann, C., Sivik, J., Mierski, J., Silar, B., Vajdic, C., Greiner, R., Brown, V., Hohl, R., Claxton, D., Shike, H. & Paules, C. I. & 2 others, , Aug 2024, In: Leukemia Research. 143, 107530.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma
Guare, E. G., Hale, C. M., Sivik, J., Lehman, E., Inoue, Y., Rakszawski, K., Songdej, N., Nickolich, M., Zheng, H., Naik, S., Claxton, D., Rybka, W., Hohl, R., Mineishi, S., Minagawa, K. & Paules, C. I., Apr 2024, In: Transplant Infectious Disease. 26, 2, e14241.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Tolerability and outcomes with rollout of tixagevimab-cilgavimab in patients with common variable immunodeficiency
Dluzynski, D., Al-Shaikhly, T., Paules, C. I. & Henao, M. P., Aug 2024, In: Journal of Allergy and Clinical Immunology: Global. 3, 3, 100293.Research output: Contribution to journal › Article › peer-review
Open Access