Projects per year
Personal profile
Research interests
Dr. Catharine I. Paules joined the faculty of Penn State College of Medicine in July 2018. She is a clinician-investigator with a research focus on COVID-19, emerging respiratory viruses and infections in bone marrow transplant recipients.
Dr. Paules was the site principle investigator (PI) for the NIAID-sponsored Adaptive COVID-19 treatment trial and the NIH-sponsored ACTIV-5 / Big Effect Trial (BET-B) for the Treatment of COVID-19. She is now the site PI for the NIH sponsored STRIVE trial to study strategies and treatments for patients with COVID-19 and other respiratory viruses. She is also involved in the COVID-19 Project ECHO for Nursing Homes and the NIH Recover initiative for Long COVID.
Teaching and educational interests
Dr. Paules is committed to the mentorship and teaching of medical students, residents, fellows and other trainees. She has multiple publications involving trainees and in 2021 a resident she mentored received the resident research award. Dr. Paules is also actively engaged in community education with involvement in infectious diseases educational forums and media outreach.
Clinical interests
Dr. Paules developed an infectious diseases consult service at Penn State Health for patients who have received (or are planned to receive) a bone marrow transplant. This specialty service sees patients in both the inpatient and outpatient setting. Dr. Paules is also involved in Bio-preparedness and serves as a member of Penn State Health's Special Pathogens Team. She was integral in the institution's clinical, research, and logistical responses to the COVID-19 pandemic.
Professional information
Board-certified, Internal Medicine, American Board of Internal Medicine, 2015
Board-certified, Infectious Diseases, American Board of Internal Medicine, 2016
Alpha Omega Alpha (AOA) Honor Medical Society, University of Nebraska Medical Center, 2011
Education/Academic qualification
Infectious Diseases, Fellowship, National Institutes of Health
… → 2016
Internal Medicine, Residency, University of Maryland Medical Center
… → 2014
MD, University of Nebraska
… → 2011
BS, College of William and Mary
… → 2007
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Projects
- 3 Finished
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients with COVID-19
Young, B. E. B. E. (PI) & Paules, C. (PI)
National Research Foundation Singapore
10/1/20 → 9/30/22
Project: Research project
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A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Boon, L. C. L. C. (PI) & Paules, C. (PI)
National Research Foundation Singapore
3/16/20 → 3/15/22
Project: Research project
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Analyzing Real-World Infection Risk in Multiple Myeloma Patients Receiving Teclistamab
Ssentongo, P., Guare, E. G., Song, C., Inoue, Y., Sandhu, M., Annageldiyev, C., Sivik, J., Rakszawski, K., Naik, S., Minagawa, K., Mineishi, S. & Paules, C. I., Mar 2026, In: Current Oncology. 33, 3, 154.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19
for the STRIVE Network and TICO Trial Study Group, Dec 2025, In: BMC Infectious Diseases. 25, 1, 67.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Dose-dependent impact of tixagevimab–cilgavimab as primary prevention against SARS-CoV-2 in immunocompromised individuals
Dluzynski, D., Ssentongo, P., Hale, C. M., Shaheen, S. K., Maglakelidze, N., Sivik, J. M., Henao, M. P., Chinchilli, V. M. & Paules, C. I., Dec 2025, In: Scientific reports. 15, 1, 17578.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Respiratory and Other Infections Following COVID
RECOVER Consortium, Sep 1 2025, In: Pediatrics. 156, 3, e2024068280.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2
Paules, C. I., Wang, J., Tomashek, K. M., Bonnett, T., Singh, K., Marconi, V. C., Davey, R. T., Lye, D. C., Dodd, L. E., Yang, O. O., Benson, C. A., Deye, G. A., Doernberg, S. B., Hynes, N. A., Grossberg, R., Wolfe, C. R., Nayak, S. U., Short, W. R., Voell, J. & Potter, G. E. & 1 others, , Mar 1 2024, In: Annals of internal medicine. 177, 3, p. 343-352 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations