Projects per year
Personal profile
Research interests
The overall focus of Dr. Joseph Wang's laboratory is to understand the molecular mechanisms underlying the complex life cycle of viruses using cryo-electron (cryo-EM) microscopy. His laboratory utilizes both single particle and electron tomography approaches to study virus structures as well as the interactions between viral proteins and host factors. The optimal goal is to use obtained structural information for developing effective drug intervention against virus infection.
Currently, Dr. Wang's lab has three major focuses:
- Structural study of Hepatitis B virus (HBV) and subviral particles
- Dissecting the molecular details of HBV entry and fusion process
- Molecular mechanism of alphavirus fusion
Teaching and educational interests
Dr. Wang has taught multiple courses during his graduate and postgraduate career, including Introduction to Computers (undergraduate level), Biological Electron Microscopy (graduate level) and Introduction to Quantitative Biology and Measurement (graduate level).
His philosophy of education is that the role of a teacher should not be to impress students with their knowledge of a given subject. Rather, it should be to make a subject so interesting that it inspires students to become self-motivated in learning about it.
In addition, Dr. Wang has mentored the research training of undergraduate and graduate students and served on doctoral committees for graduate students.
Dr. Wang teaches virology classes at the College of Medicine, including BMS564 Concepts in Virology (fall semester) and MICRO550 Medical Microbiology (spring semester).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Structural Biology, Postdoctoral Fellowship, Indiana University Bloomington
2010 → 2013
Structural Biology, PhD, National Yang-Ming University
2001 → 2008
Medical Informatics, MSc, National Yang-Ming University
1999 → 2001
Biology, BSc, Fu Jen Catholic University
1995 → 1999
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Dissecting Structural Details of Hepadnavirus Subviral Particles
5/19/21 → 4/30/23
Project: Research project
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Core Protein-Directed Antivirals and Importin b Can Synergistically Disrupt Hepatitis B Virus Capsids
Kim, C., Barnes, L. F., Schlicksup, C. J., Patterson, A. J., Bothner, B., Jarrold, M. F., Wang, C. Y. J. & Zlotnick, A., Jan 2022, In: Journal of virology. 96, 2, A4.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles
Liu, H., Hong, X., Xi, J., Menne, S., Hu, J. & Che-Yen Wang, J., Aug 2022, In: Science Advances. 8, 31, eabo4184.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Hypochlorous acid as a disinfectant for high-risk HPV: Insight into the mechanism of action
Robins, L. I., Clark, A., Gafken, P. R., Alam, S., Milici, J., Hassan, R., Wang, C. Y., Williams, J. & Meyers, C., Jul 2022, In: Journal of Medical Virology. 94, 7, p. 3386-3393 8 p.Research output: Contribution to journal › Article › peer-review
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Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes
Ren, S. C., Qazi, S. A., Towell, B., Wang, J. C. Y. & Mukhopadhyay, S., Mar 2022, In: Journal of virology. 96, 5, e02149-21.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating
Xi, J., Cui, X., Liu, K., Liu, H., Wang, J. & Hu, J., Apr 2022, In: Journal of virology. 96, 8Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
Aprile, Bettina (Recipient), Aumiller, Betsy B. (Recipient), Berkey, Franklin (Recipient), Bonavia, Anthony (Recipient), Booth, Jennifer (Recipient), Brennan, Kristin (Recipient), Browning, Kirsteen (Recipient), Buchkovich, Nicholas (Recipient), Butt, Fauzia K. (Recipient), Carrel, Laura (Recipient), Choe, Angela (Recipient), Clarke, Sheila (Recipient), Coleman, Melissa (Recipient), Dalke, Katharine (Recipient), Devaraj, Tara (Recipient), Duryea, Stacey (Recipient), Enama, Joseph (Recipient), Evey, Loren (Recipient), Finch, Elizabeth (Recipient), Fischer, Michelle (Recipient), Gallo, Robert (Recipient), Gavigan, Patrick (Recipient), Ghaffari, Gisoo (Recipient), Go, Pauline (Recipient), Grana, Jennifer (Recipient), Greensmith, James (Recipient), Grogan, James (Recipient), Hajnal, Andras (Recipient), Helm, Matthew (Recipient), Hempel, Nadine (Recipient), Imamura, Fumiaki (Recipient), Jain, Rohit (Recipient), Jeganathan, Nimalan (Recipient), Kelle, Angela (Recipient), Kumar, Ashutosh (Recipient), Kwun, Hyun Jin (Recipient), Lang, Charles (Recipient), Lutzkanin, Andrew (Recipient), Martin, Kathryn (Recipient), McGarrity, Thomas (Recipient), McHale, Katie (Recipient), McLaughlin, Patricia (Recipient), Mormando, Charles (Recipient), Nguyen, Joseph (Recipient), Nickolich, Myles (Recipient), Ouyang, Tao (Recipient), Pachuski, Justin (Recipient), Polimera, Hyma (Recipient), Potochny, Evelyn (Recipient), Rakszawski, Kevin L. (Recipient), Reyes, Lilia (Recipient), Sankoorikal, Binu-john (Recipient), Shantz, Lisa (Recipient), Singh, Madhavi (Recipient), Songdej, Natthapol (Recipient), Spotts, Ryan (Recipient), Swigart, Alison (Recipient), Varner, Malina (Recipient), Verma, Navin (Recipient), Walter, Vonn (Recipient), Wang, Che-Yen "Joseph" (Recipient), Warfield, Dennis (Recipient), Wilson, Meghan N. (Recipient) & Hussein, Rezhan (Recipient), 2021
Prize
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