Projects per year
Personal profile
Research interests
The overall focus of Dr. Joseph Wang's laboratory is to understand the molecular mechanisms underlying the complex life cycle of viruses using cryo-electron (cryo-EM) microscopy. His laboratory utilizes both single particle and electron tomography approaches to study virus structures as well as the interactions between viral proteins and host factors. The optimal goal is to use obtained structural information for developing effective drug intervention against virus infection.
Currently, Dr. Wang's lab has three major focuses:
- Structural study of Hepatitis B virus (HBV) and subviral particles
- Dissecting the molecular details of HBV entry and fusion process
- Molecular mechanism of alphavirus fusion
Teaching and educational interests
Dr. Wang has taught multiple courses during his graduate and postgraduate career, including Introduction to Computers (undergraduate level), Biological Electron Microscopy (graduate level) and Introduction to Quantitative Biology and Measurement (graduate level).
His philosophy of education is that the role of a teacher should not be to impress students with their knowledge of a given subject. Rather, it should be to make a subject so interesting that it inspires students to become self-motivated in learning about it.
In addition, Dr. Wang has mentored the research training of undergraduate and graduate students and served on doctoral committees for graduate students.
Dr. Wang teaches virology classes at the College of Medicine, including BMS564 Concepts in Virology (fall semester) and MICRO550 Medical Microbiology (spring semester).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Structural Biology, Postdoctoral Fellowship, Indiana University Bloomington
2010 → 2013
Structural Biology, PhD, National Yang-Ming University
2001 → 2008
Medical Informatics, MSc, National Yang-Ming University
1999 → 2001
Biology, BSc, Fu Jen Catholic University
1995 → 1999
Fingerprint
Dive into the research topics where Che-Yen "Joseph" Wang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Structural characterization of native HBV capsids and virions from human cells
Wang, C.-Y. (PI)
National Institute of Allergy and Infectious Diseases
6/14/23 → 5/31/28
Project: Research project
-
Dissecting Structural Details of Hepadnavirus Subviral Particles
Wang, C.-Y. (PI)
5/19/21 → 4/30/23
Project: Research project
-
Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes
Hong, X., Bianchini, E. N., Wang, J. C. Y. & Hu, J., Jan 2023, In: mBio. 14, 1Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Protein Structure Predictions, Atomic Model Building, and Validation Using a Cryo-EM Density Map from Hepatitis B Virus Spherical Subviral Particle
DiNunno, N., Bianchini, E. N., Liu, H. & Wang, J. C. Y., Jul 20 2023, In: Bio-protocol. 13, 14, e4751.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit
Kim, C., Schlicksup, C. J., Pérez-Segura, C., Hadden-Perilla, J. A., Wang, J. C. Y. & Zlotnick, A., Sep 2023, In: Journal of Biological Chemistry. 299, 9, 105104.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Core Protein-Directed Antivirals and Importin b Can Synergistically Disrupt Hepatitis B Virus Capsids
Kim, C., Barnes, L. F., Schlicksup, C. J., Patterson, A. J., Bothner, B., Jarrold, M. F., Wang, C. Y. J. & Zlotnick, A., Jan 2022, In: Journal of virology. 96, 2, A4.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles
Liu, H., Hong, X., Xi, J., Menne, S., Hu, J. & Che-Yen Wang, J., Aug 2022, In: Science Advances. 8, 31, eabo4184.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations
Prizes
-
Dean's Award for Excellence in Teaching
Aprile, B. (Recipient), Aumiller, B. B. (Recipient), Berkey, F. (Recipient), Bonavia, A. (Recipient), Booth, J. (Recipient), Brennan, K. (Recipient), Browning, K. (Recipient), Buchkovich, N. (Recipient), Butt, F. K. (Recipient), Carrel, L. (Recipient), Choe, A. (Recipient), Clarke, S. (Recipient), Coleman, M. (Recipient), Dalke, K. (Recipient), Devaraj, T. (Recipient), Duryea, S. (Recipient), Enama, J. (Recipient), Evey, L. (Recipient), Finch, E. (Recipient), Fischer, M. (Recipient), Gallo, R. (Recipient), Gavigan, P. (Recipient), Ghaffari, G. (Recipient), Go, P. (Recipient), Grana, J. (Recipient), Greensmith, J. (Recipient), Grogan, J. (Recipient), Hajnal, A. (Recipient), Helm, M. (Recipient), Hempel, N. (Recipient), Imamura, F. (Recipient), Jain, R. (Recipient), Jeganathan, N. (Recipient), Kelle, A. (Recipient), Kumar, A. (Recipient), Kwun, H. J. (Recipient), Lang, C. (Recipient), Lutzkanin, A. (Recipient), Martin, K. (Recipient), McGarrity, T. (Recipient), McHale, K. (Recipient), McLaughlin, P. (Recipient), Mormando, C. (Recipient), Nguyen, J. (Recipient), Nickolich, M. (Recipient), Ouyang, T. (Recipient), Pachuski, J. (Recipient), Polimera, H. (Recipient), Potochny, E. (Recipient), Rakszawski, K. L. (Recipient), Reyes, L. (Recipient), Sankoorikal, B.-J. (Recipient), Shantz, L. (Recipient), Singh, M. (Recipient), Songdej, N. (Recipient), Spotts, R. (Recipient), Swigart, A. (Recipient), Varner, M. (Recipient), Verma, N. (Recipient), Walter, V. (Recipient), Wang, C.-Y. (Recipient), Warfield, D. (Recipient), Wilson, M. N. (Recipient) & Hussein, R. (Recipient), 2021
Prize
-