Projects per year
Personal profile
Research interests
The overall focus of Dr. Joseph Wang's laboratory is to understand the molecular mechanisms underlying the complex life cycle of viruses using cryo-electron (cryo-EM) microscopy. His laboratory utilizes both single particle and electron tomography approaches to study virus structures as well as the interactions between viral proteins and host factors. The optimal goal is to use obtained structural information for developing effective drug intervention against virus infection.
Currently, Dr. Wang's lab has three major focuses:
- Structural study of Hepatitis B virus (HBV) and subviral particles
- Dissecting the molecular details of HBV entry and fusion process
- Molecular mechanism of alphavirus fusion
Teaching and educational interests
Dr. Wang has taught multiple courses during his graduate and postgraduate career, including Introduction to Computers (undergraduate level), Biological Electron Microscopy (graduate level) and Introduction to Quantitative Biology and Measurement (graduate level).
His philosophy of education is that the role of a teacher should not be to impress students with their knowledge of a given subject. Rather, it should be to make a subject so interesting that it inspires students to become self-motivated in learning about it.
In addition, Dr. Wang has mentored the research training of undergraduate and graduate students and served on doctoral committees for graduate students.
Dr. Wang teaches virology classes at the College of Medicine, including BMS564 Concepts in Virology (fall semester) and MICRO550 Medical Microbiology (spring semester).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Structural Biology, Postdoctoral Fellowship, Indiana University Bloomington
2010 → 2013
Structural Biology, PhD, National Yang-Ming University
2001 → 2008
Medical Informatics, MSc, National Yang-Ming University
1999 → 2001
Biology, BSc, Fu Jen Catholic University
1995 → 1999
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Collaborations and top research areas from the last five years
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Structural characterization of native HBV capsids and virions from human cells
Wang, C.-Y. (PI)
National Institute of Allergy and Infectious Diseases
6/14/23 → 5/31/28
Project: Research project
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Dissecting Structural Details of Hepadnavirus Subviral Particles
Wang, C.-Y. (PI)
5/19/21 → 4/30/23
Project: Research project
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Bilayer or Not: Revisiting the Structural Nature of HBV Subviral Particles
Liu, H., Garg, S., Hu, J. & Wang, J. C. Y., Feb 2025, In: Journal of Medical Virology. 97, 2, e70212.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity
Tsvetkova, I. B., Roos, N., Miller, L. M., DiNunno, N., Conrady, M., Ebert, D., Lilie, H., Scott, L. W., Jarrold, M. F., Wang, J. C. Y., Simon, C. & Dragnea, B., Jan 14 2025, In: ACS nano. 19, 1, p. 479-487 9 p.Research output: Contribution to journal › Article › peer-review
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Unveiling the Molecular Architecture of HBV Spherical Subviral Particles: Structure, Symmetry, and Lipid Dynamics
Garg, S., Ochetto, A., Hu, J. & Wang, J. C. Y., Jan 2025, In: Viruses. 17, 1, 48.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation
Laughlin, P. M., Young, K., Gonzalez-Gutierrez, G., Wang, J. C. Y. & Zlotnick, A., Nov 2024, In: Journal of Biological Chemistry. 300, 11, 107831.Research output: Contribution to journal › Article › peer-review
Open Access -
Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles: Polymorphism in Norovirus GI.1
Miller, L. M., Draper, B. E., Wang, J. C. Y. & Jarrold, M. F., Aug 13 2024, In: Analytical Chemistry. 96, 32, p. 13150-13157 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
Aprile, B. (Recipient), Aumiller, B. B. (Recipient), Berkey, F. (Recipient), Bonavia, A. (Recipient), Booth, J. (Recipient), Brennan, K. (Recipient), Browning, K. (Recipient), Buchkovich, N. (Recipient), Butt, F. K. (Recipient), Carrel, L. (Recipient), Choe, A. (Recipient), Clarke, S. (Recipient), Coleman, M. (Recipient), Dalke, K. (Recipient), Devaraj, T. (Recipient), Duryea, S. (Recipient), Enama, J. (Recipient), Evey, L. (Recipient), Finch, E. (Recipient), Fischer, M. (Recipient), Gallo, R. (Recipient), Gavigan, P. (Recipient), Ghaffari, G. (Recipient), Go, P. (Recipient), Grana, J. (Recipient), Greensmith, J. (Recipient), Grogan, J. (Recipient), Hajnal, A. (Recipient), Helm, M. (Recipient), Hempel, N. (Recipient), Imamura, F. (Recipient), Jain, R. (Recipient), Jeganathan, N. (Recipient), Kelle, A. (Recipient), Kumar, A. (Recipient), Kwun, H. J. (Recipient), Lang, C. (Recipient), Lutzkanin, A. (Recipient), Martin, K. (Recipient), McGarrity, T. (Recipient), McHale, K. (Recipient), McLaughlin, P. (Recipient), Mormando, C. (Recipient), Nguyen, J. (Recipient), Nickolich, M. (Recipient), Ouyang, T. (Recipient), Pachuski, J. (Recipient), Polimera, H. (Recipient), Potochny, E. (Recipient), Rakszawski, K. L. (Recipient), Reyes, L. (Recipient), Sankoorikal, B.-J. (Recipient), Shantz, L. (Recipient), Singh, M. (Recipient), Songdej, N. (Recipient), Spotts, R. (Recipient), Swigart, A. (Recipient), Varner, M. (Recipient), Verma, N. (Recipient), Walter, V. (Recipient), Wang, C.-Y. (Recipient), Warfield, D. (Recipient), Wilson, M. N. (Recipient) & Hussein, R. (Recipient), 2021
Prize
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