Projects per year
Personal profile
Research interests
The lab of Christopher Chen is broadly interested in the cerebellum and how its connections with the rest of the brain underly behavior. The cerebellum is critically important for motor coordination, but its specific nonmotor roles are much more enigmatic. A multitude of pathways connecting the cerebellum to a diversity of structures unrelated to motor control have been discovered, suggesting a diversity of function that has barely been explored. The lab uses a combination of classic in vitro electrophysiology, in vivo multielectrode recordings, calcium imaging, anatomical tracing, and targetted behavioral assays to understand how exactly the cerebellum plays a role in these nonmotor functions. Alongside a strong focus on cutting edge, impactful science, the lab is a training ground for passionate thinkers and tinkers, and is committed to the advancement and growth of all of its members.
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Cerebellar Outputs Through an Unconventional Nucleus
Chen, C. (PI)
National Institute of Neurological Disorders and Stroke
4/1/23 → 3/31/24
Project: Research project
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Cerebellar Outputs Through an Unconventional Nucleus
Chen, C. (PI)
National Institute of Neurological Disorders and Stroke
4/1/20 → 3/31/21
Project: Research project
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Cerebellar Outputs
Chen, C. (PI)
National Institute of Neurological Disorders and Stroke
4/1/17 → 3/31/20
Project: Research project
Research output
- 17 Article
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Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs
Wu, S., Wardak, A., Khan, M. M., Chen, C. H. & Regehr, W. G., 2024, In: eLife. 13, e89095.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain
Chen, C. H., Newman, L. N., Stark, A. P., Bond, K. E., Zhang, D., Nardone, S., Vanderburg, C. R., Nadaf, N. M., Yao, Z., Mutume, K., Flaquer, I., Lowell, B. B., Macosko, E. Z. & Regehr, W. G., Nov 2023, In: Nature Neuroscience. 26, 11, p. 1929-1941 13 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Cerebellar granule cell signaling is indispensable for normal motor performance
Lee, J. H., Khan, M. M., Stark, A. P., Seo, S., Norton, A., Yao, Z., Chen, C. H. & Regehr, W. G., May 30 2023, In: Cell Reports. 42, 5, 112429.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Mechanism of stress-induced attacks in an episodic neurologic disorder
Snell, H. D., Vitenzon, A., Tara, E., Chen, C., Tindi, J., Jordan, B. A. & Khodakhah, K., Apr 2022, In: Science Advances. 8, 16, eabh2675.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale
Khan, M. M., Wu, S., Chen, C. H. & Regehr, W. G., Oct 5 2022, In: Journal of Neuroscience. 42, 40, p. 7581-7593 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations