Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Cross validation of gene expression changes in C9orf72 FTD using Drosophila and human model systems
Zarnescu, D. (PI) & Sattler, R. R. (CoPI)
National Institute of Neurological Disorders and Stroke
6/1/25 → 5/31/27
Project: Research project
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Mechanisms underlying TDP-43 dependent structural deficits in ALS muscles
Zarnescu, D. (PI) & Pasinelli, P. P. (CoPI)
5/1/25 → 4/30/27
Project: Research project
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Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-to-Human' Approach
Zarnescu, D. (PI)
5/1/22 → …
Project: Research project
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Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-to-Human' Approach
Zarnescu, D. (PI)
Congressionally Directed Medical Research Programs
1/1/21 → …
Project: Research project
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Small Molecules Targeting TDP-43-RNA Interactions in ALS
Zarnescu, D. (PI)
7/1/18 → …
Project: Research project
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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS Erratum to: PIKFYVE inhibition mitigates disease in models of diverse forms of ALS (Cell, (2023), 186, 4, (786-802.e28), (S0092867423000053), (10.1016/j.cell.2023.01.005))
Hung, S. T., Linares, G. R., Chang, W. H., Eoh, Y., Krishnan, G., Mendonca, S., Hong, S., Shi, Y., Santana, M., Kueth, C., Macklin-Isquierdo, S., Perry, S., Duhaime, S., Maios, C., Chang, J., Perez, J., Couto, A., Lai, J., Li, Y. & Alworth, S. V. & 8 others, , Feb 5 2026, In: Cell. 189, 3, p. 987-992 6 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
Godfrey, R. K., Alsop, E., Bjork, R. T., Chauhan, B. S., Ruvalcaba, H. C., Antone, J., Gittings, L. M., Michael, A. F., Williams, C., Hala’ufia, G., Blythe, A. D., Hall, M., Sattler, R., Van Keuren-Jensen, K. & Zarnescu, D. C., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 168.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Hung, S. T., Linares, G. R., Chang, W. H., Eoh, Y., Krishnan, G., Mendonca, S., Hong, S., Shi, Y., Santana, M., Kueth, C., Macklin-Isquierdo, S., Perry, S., Duhaime, S., Maios, C., Chang, J., Perez, J., Couto, A., Lai, J., Li, Y. & Alworth, S. V. & 8 others, , Feb 16 2023, In: Cell. 186, 4, p. 786-802.e28Research output: Contribution to journal › Article › peer-review
Open Access78 Link opens in a new tab Scopus citations -
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
Bjork, R. T., Mortimore, N. P., Loganathan, S. & Zarnescu, D. C., Mar 7 2022, In: Frontiers in Neuroscience. 16, 840357.Research output: Contribution to journal › Review article › peer-review
Open Access23 Link opens in a new tab Scopus citations -
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Loganathan, S., Wilson, B. A., Carey, S. B., Manzo, E., Joardar, A., Ugur, B. & Zarnescu, D. C., Feb 2022, In: Metabolites. 12, 2, 101.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
Hussein, R. (Recipient), Stredny, E. (Recipient), Whitley, M. (Recipient), Mnatsakanyan, N. (Recipient), Raimundo, N. (Recipient), Zarnescu, D. (Recipient), Adams, N. (Recipient), Lanza, M. (Recipient), Kowalczyk, A. (Recipient), Travelute, C. (Recipient), Marco, C. (Recipient), Tondt, J. (Recipient), Anderson, A. (Recipient), Heron, C. (Recipient), Newman, R. (Recipient), Richard, D. (Recipient), Scartozzi, C. (Recipient), Dellasega, C. (Recipient), Akhtar, N. (Recipient), Albano-Aluquin, S. (Recipient), Chisty, A. (Recipient), Crook, T. (Recipient), Federici, E. H. (Recipient), Ingram, D. (Recipient), Lakshmanan, P. (Recipient), Mathew, A. (Recipient), Narayana, S. (Recipient), Prokop, A. (Recipient), Razjouyan, H. (Recipient), Tariq, A. (Recipient), Thompson, B. (Recipient), Thompson, E. (Recipient), Trivedi, N. (Recipient), Van Scoy, L. (Recipient), Wong, J. (Recipient), Allie, S. R. (Recipient), Browning, K. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Mamarabadi, M. (Recipient), Shankar, L. (Recipient), Bowie, E. (Recipient), Petfield, J. (Recipient), Whitaker, M. (Recipient), Aynardi, J. (Recipient), Allen, N. (Recipient), Cunningham, B. (Recipient), Gandhi, C. (Recipient), Jairath, B. (Recipient), Lutzkanin, K. M. (Recipient), Kerris, E. (Recipient), Nelson, A. (Recipient), Shook, J. (Recipient), Proctor, E. A. (Recipient), Raup-Konsavage, W. (Recipient), Romanoski, N. (Recipient), Graziane, J. (Recipient), Llorente, A. (Recipient), Nutting, S. (Recipient), Pinto, C. (Recipient), Yingst, J. (Recipient), Zhou, S. (Recipient), Mahase, S. (Recipient), Brian, P. (Recipient), Goldman, E. (Recipient), Maffie, J. (Recipient), Brahmbhatt, R. (Recipient), Fahy, A. (Recipient), Gish, J. (Recipient), Reed, M. F. (Recipient) & Tomasko, J. (Recipient), 2024
Prize