Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Tissue Repository and Animal Models Core
Claxton, D. & Claxton, D. D. F.
5/1/20 → 5/31/24
Project: Research project
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. G., Cabot, M. C., Claxton, D., Fox, T. E., Kester, M., Liao, J., Loughran, T. P., Wang, H., Loughran, T. T. P., Horton, B. B. J., Chalfant, C. C. E., Conaway, M., Janes, K. A. & Cabot, M. M. C.
9/10/13 → 5/31/24
Project: Research project
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Animal Modeling and Clinical Resources Core
Claxton, D. & Kester, M.
9/10/13 → 8/31/18
Project: Research project
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CORE BINDING FACTOR IN LEUKEMOGENESIS--INV(16) AND T(8;21)
10/1/95 → 9/30/01
Project: Research project
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
Qian, F., Nettleford, S. K., Zhou, J., Arner, B. E., Hall, M. A., Sharma, A., Annageldiyev, C., Rossi, R. M., Tukaramrao, D. B., Sarkar, D., Hegde, S., Gandhi, U. H., Finch, E. R., Goodfield, L., Quickel, M. D., Claxton, D. F., Paulson, R. F. & Prabhu, K. S., Jul 25 2023, In: Cell Reports. 42, 7, 112794.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
Jia, B., Zhao, C., Minagawa, K., Shike, H., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Mineishi, S., Wang, M., Schell, T. D., Prabhu, K. S., Paulson, R. F., Zhang, Y., Shultz, L. D. & Zheng, H., Nov 1 2023, In: Journal of Immunology. 211, 9, p. 1426-1437 12 p.Research output: Contribution to journal › Article › peer-review
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Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis
Cioccio, J., Rakszawski, K., Zheng, H., Nickolich, M., Naik, S., Wirk, B., Rybka, W., Ehmann, C., Silar, B., Vajdic, C., Shah, N., Tuanquin, L., Greiner, R., Brown, V., Hohl, R., Claxton, D., Mineishi, S., Minagawa, K. & Shike, H., Mar 2023, In: Annals of Hematology. 102, 3, p. 613-620 8 p.Research output: Contribution to journal › Article › peer-review
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IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients
Potiaumpai, M., Schmitz, K. H., Mineishi, S., Naik, S., Wirk, B., Rakszawski, K., Ehmann, W. C., Claxton, D., Nickolich, M., Zemel, B. S. & Zheng, H., Jan 18 2023, In: BMJ open. 13, 1, e066841.Research output: Contribution to journal › Article › peer-review
Open Access -
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia
Fisher-Wellman, K. H., Kassai, M., Hagen, J. T., Neufer, P. D., Kester, M., Loughran, T. P., Chalfant, C. E., Feith, D. J., Tan, S. F., Fox, T. E., Ung, J., Fabrias, G., Abad, J. L., Sharma, A., Golla, U., Claxton, D. F., Shaw, J. J. P., Bhowmick, D. & Cabot, M. C., Mar 2023, In: Cancers. 15, 6, 1883.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Outstanding Collaborative Research Team
Adair, James Hansell (Recipient), Amin, Shantu (Recipient), Claxton, David (Recipient), Desai, Dhimant (Recipient), Hengst, Jeremy (Recipient), Liao, Jiangang "Jason" (Recipient), Paulson, Robert (Recipient), Sharma, Arun (Recipient), Stanley, Bruce (Recipient), Wang, Hong-Gang (Recipient), Yun, Jong (Recipient) & Zhu, Junjia (Recipient), 2015
Prize