Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Projects
- 8 Finished
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. (CoPI), Cabot, M. C. (CoPI), Claxton, D. (CoPI), Fox, T. E. (CoPI), Kester, M. (CoPI), Liao, J. (CoPI), Loughran, T. P. (CoPI), Wang, H.-G. (CoPI), Horton, B. B. J. (CoPI), Chalfant, C. C. E. (CoPI), Conaway, M. (CoPI) & Janes, K. A. (CoPI)
9/10/13 → 5/31/25
Project: Research project
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Animal Modeling and Clinical Resources Core
Claxton, D. (PI) & Kester, M. (CoPI)
9/10/13 → 8/31/18
Project: Research project
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CLINICAL TRIAL: PI TRIAL OF IMMUNOSTIMULATION JVRS-100 FOR RELAPSED OR REFRACTOR
Leuenberger, U. U. A. (PI) & Claxton, D. (PI)
National Center for Research Resources
4/1/07 → 3/31/10
Project: Research project
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CORE BINDING FACTOR IN LEUKEMOGENESIS--INV(16) AND T(8;21)
Claxton, D. (PI)
10/1/95 → 9/30/01
Project: Research project
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HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia
Hamamoto, K., Zhu, G., Lai, Q., Lesperance, J., Luo, H., Li, Y., Nigam, N., Sharma, A., Yang, F. C., Claxton, D., Qiu, Y., Aplan, P. D., Xu, M. & Huang, S., Apr 1 2025, In: Journal of Clinical Investigation. 135, 7, e184743.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes
Paudel, B. B., Tan, S. F., Fox, T. E., Ung, J., Golla, U., Shaw, J. J. P., Dunton, W., Lee, I., Fares, W. A., Patel, S., Sharma, A., Viny, A. D., Barth, B. M., Tallman, M. S., Cabot, M., Garrett-Bakelman, F. E., Levine, R. L., Kester, M., Feith, D. J. & Claxton, D. & 2 others, , Mar 12 2024, In: Blood Advances. 8, 5, p. 1137-1142 6 p.Research output: Contribution to journal › Letter › peer-review
Open Access5 Scopus citations -
A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma
Pu, J. J., Berger, K. N., Zheng, C., Do, N., Claxton, D. F., Ehmann, W. C., Drabick, J. J., Li, H., Loughran, T. P. & Epner, E. M., 2024, In: Frontiers in Oncology. 14, 1449401.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods
Brow, D., Shike, H., Kendrick, J., Pettersson, L., Mineishi, S., Claxton, D. F., Wirk, B., Cioccio, J., Greiner, R. J., Viswanatha, D., Kharfan-Dabaja, M. A., Li, Z., Tyler, J. & Elrefaei, M., May 2024, In: Human Immunology. 85, 3, 110794.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia
Naik, S., Rakszawski, K., Zheng, H., Claxton, D., Minagawa, K. & Mineishi, S., Jan 2024, In: International journal of molecular sciences. 25, 2, 957.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Prizes
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize