Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Ceramide-Directed Therapeutics for Treatment of AML
Chalfant, C. C. E. (CoPI), Chalfant, C. C. E. (CoPI), Claxton, D. (CoPI), Zhu, H. H. (CoPI), Fisher-wellman, K. K. H. (CoPI), Janes, K. A. (CoPI), Loughran, T. T. P. (CoPI) & Fox, T. T. E. (CoPI)
9/1/25 → 8/31/27
Project: Research project
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Tissue Repository and Animal Models Core
Claxton, D. (PI) & Claxton, D. D. F. (PI)
5/1/20 → 5/31/25
Project: Research project
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CLINICAL TRIAL: PI TRIAL OF IMMUNOSTIMULATION JVRS-100 FOR RELAPSED OR REFRACTOR
Leuenberger, U. U. A. (PI) & Claxton, D. (PI)
National Center for Research Resources
4/1/07 → 3/31/10
Project: Research project
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Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia
Ung, J., Tan, S. F., Shaw, J. J. P., Taori, M., Deddens, T. M., Venancio, G., Montgomery, M. M., Hagen, J. T., Aruleba, R. T., Golla, U. R., Sharma, A., Paudel, B. B., Lee, I., Ramamoorthy, B., Janes, K. A., Garrett-Bakelman, F., Cabot, M. C., Fisher-Wellman, K. H., Fox, T. E. & Claxton, D. F. & 3 others, , May 2026, In: Blood Neoplasia. 3, 2, 100196.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Erratum: Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia (10.1200/JOP.19.00133)
Pagel, J. M., Othus, M., Garcia-Manero, G., Fang, M., Radich, J. P., Rizzieri, D. A., Marcucci, G., Strickland, S. A., Litzow, M. R., Savoie, M. L., Spellman, S. R., Confer, D. L., Chell, J. W., Brown, M., Medeiros, B. C., Sekeres, M. A., Lin, T. L., Uy, G. L., Powell, B. L. & Bayer, R. L. & 9 others, , Jun 2026, In: JCO Oncology Practice. 22, 6, p. 1140 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Long-term follow-up of a pediatric regimen for AYA with Ph-negative ALL: 10-year survival of CALGB 10403 (alliance)
Silva, W. F., Yin, J., Liedtke, M., Claxton, D. F., Fulton, N., Giri, S., Malnassy, G., Mrózek, K., Paietta, E., Mullighan, C. G., Galinsky, I., Bogart, J. A., Grecula, J. C., Kennedy, L. A., Larson, R. A., Stone, R. M., Uy, G. L., Luger, S. M., Advani, A. S. & Stock, W., Aug 25 2026, In: Blood Advances. 10, 16, p. 5487-5491 5 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Pharmacological blockade of rho kinase enhances venetoclax responses in translational models of acute myeloid leukemia
Golla, U., Bhalodia, R., Annageldiyev, C., Patel, S., Bollu, V. S., Tan, S. F., Cabot, M. C., Feith, D. J., Loughran, T. P., Levine, R. L., Mineishi, S., Zheng, H., Minagawa, K., Hengst, J., Saulnier Sholler, G. L., Desai, D., Dovat, S., Fisher-Wellman, K. H., Claxton, D. F. & Sharma, A., 2026, In: Haematologica.Research output: Contribution to journal › Letter › peer-review
Open Access -
Survival after intensive therapy or clofarabine in fit older adults with acute myeloid leukemia: E2906 phase 3 trial
Foran, J. M., Sun, Z., Luger, S. M., Claxton, D. F., Lazarus, H. M., Arber, D. A., Rowe, J. M., Paietta, E., Racevskis, J., Garrett-Bakelman, F., Zhang, Y., Altman, J. K., Al-Kali, A., Zheng, H., Pratz, K. W., Broun, E. R., Powell, B. L., O'Dwyer, K. M., Godwin, J. E. & Ofran, Y. & 2 others, , May 2026, In: Blood Neoplasia. 3, 2, 100194.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize