Projects per year
Personal profile
Research interests
Dr. David Waning's research focuses on the emerging importance of bone-muscle crosstalk in aging and disease.
The overarching goal of his research program is to discover and characterize molecular mechanisms that impair musculoskeletal health in disease and aging. Bone and muscle are tightly coupled during growth and development, and also during aging and disease yet the cellular and molecular mechanisms linking these two tissues are not well understood. The Waning lab is developing novel therapeutic approaches that improve musculoskeletal health in pre-clinical models of cancer and chemotherapy-induced sequelae, osteoporosis and aging.
The major aims of Dr. Waning's research are to identify and characterize signal mediators of bone-muscle crosstalk that affect musculoskeletal health. He is especially interested in identifying targets of oxidative stress that affect bone and muscle function; understanding muscle weakness in cachexia; cachexia and the relative contribution of muscle wasting and contractile dysfunction; and bone-muscle crosstalk in rare bone diseases.
Teaching and educational interests
Dr. David Waning is the director of the Cellular and Integrative Physiology Core Option in the Biomedical Sciences Graduate Program at Penn State College of Medicine.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Northwestern University
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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(PQ9) Novel therapeutic approaches to chemotherapy-induced muscle
4/5/16 → 3/31/19
Project: Research project
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Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: Effects of 4-Aminopyridine
Lee, J., Talukder, M., Karuman, Z., Gurjar, A., Govindappa, P., Guddadarangaiah, J., Manto, K., Wandling, G., Hegarty, J., Waning, D. & Elfar, J., Feb 2023, In: Neural Regeneration Research. 18, 2, p. 439-444 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Animal model detects early pathologic changes of Charcot neuropathic arthropathy
Stauch, C. M., Fanburg-Smith, J. C., Walley, K. C., King, J. L., Murie, B., Kim, M., Koroneos, Z., Waning, D., Elfar, J. C. & Aynardi, M. C., Feb 2022, In: Annals of Diagnostic Pathology. 56, 151878.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Bone-Muscle Crosstalk: Musculoskeletal Complications of Chemotherapy
Hain, B. A. & Waning, D. L., Dec 2022, In: Current Osteoporosis Reports. 20, 6, p. 433-441 9 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Bone-Muscle Crosstalk in Advanced Cancer and Chemotherapy
Waning, D. L., Jan 1 2022, The Systemic Effects of Advanced Cancer: A Textbook on Cancer-Associated Cachexia. Springer International Publishing, p. 155-167 13 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Electroporation of Plasmid DNA into Mouse Skeletal Muscle
Hain, B. A. & Waning, D. L., Apr 2022, In: Journal of Visualized Experiments. 2022, 182, e63916.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
McAlevy, Mary (Recipient), Bonavia, Anthony (Recipient), Malhotra, Anita (Recipient), Weller, Gregory E. (Recipient), Waning, David (Recipient), Lanza, Matthew (Recipient), Ken, Kimberly (Recipient), McCarver, Stewart (Recipient), Glasser, Joshua (Recipient), Schooler, Jordan (Recipient), Lewis, Sarah (Recipient), Onks, Cayce (Recipient), Rao, Ravishankar (Recipient), Nickolich, Sarah (Recipient), Helm, Leesha (Recipient), Critchfield, Laura (Recipient), Myers, Kimberly (Recipient), Green, Michael (Recipient), Songdej, Natthapol (Recipient), Narayana, Shyam (Recipient), Razjouyan, Hadie (Recipient), Duca, Nicholas (Recipient), Casas, Rachel (Recipient), Cooper, Jennifer (Recipient), Wright, Rollin (Recipient), Karasinski, Amanda (Recipient), Probolus, James Andrew "Andy" (Recipient), Madara, John (Recipient), Guck, Daniel (Recipient), Ingram, David (Recipient), De Obaldia, Anna (Recipient), Hussein, Rezhan (Recipient), McGillen, Brian (Recipient), Chapman, Tyler (Recipient), Munyon, Ryan (Recipient), Kinard, Shane R. (Recipient), Banks, Sharon (Recipient), Genao, Inginia (Recipient), McShane, Michael (Recipient), Allie, S. Rameeza (Recipient), Silberman, Yuval (Recipient), Evey, Loren (Recipient), McLaughlin, Patricia (Recipient), Grogan, James (Recipient), Nguyen, Joseph (Recipient), Donato, Heather (Recipient), Fox, Edward (Recipient), Gniady, John (Recipient), Oladipo, Olajumoke (Recipient), Abendroth, Catherine (Recipient), Keefer, Laura (Recipient), Massare, Brittany (Recipient), Undar, Akif (Recipient), Mondal, Pritish (Recipient), Mainali, Gayatra (Recipient), Jhaveri, Pooja (Recipient), Freiberg, Andrew (Recipient), Levenson, Robert (Recipient), Mailman, Richard (Recipient), Boodoo, Ramnarine (Recipient), Francis, Andrew (Recipient), Hameed, Usman (Recipient), Yadav, Sanjay (Recipient), Calo, William (Recipient), Pinto, Casey (Recipient), Cooper, Amanda (Recipient), Kulaylat, Audrey (Recipient), Scow, Jeffrey (Recipient), Roberts, John (Recipient), Winder, Joshua (Recipient), Aminsharifi, Alireza (Recipient), Adams, Nancy (Recipient) & van Riggelen, Jan (Recipient), 2023
Prize
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Dean's Award for Excellence in Teaching
Aber, Robert (Recipient), Anderson, Alyssa (Recipient), Aynardi, Michael (Recipient), Browning, Kirsteen (Recipient), Chen, Michael (Recipient), Chu, David C. (Recipient), Cios, Theodore (Recipient), Cruz, Amy (Recipient), Cruz, Jeffrey (Recipient), Dalal, Priti (Recipient), Dambro, Anthony (Recipient), Disori, Kristin (Recipient), Dodge, Daleela (Recipient), Duda, Laura (Recipient), Evey, Loren (Recipient), Fotos, Joseph (Recipient), Fredrick, N. Benjamin (Recipient), Freeman, Michael (Recipient), Gordin, Vitaly (Recipient), Graziane, Julie (Recipient), Hempel, Eliana (Recipient), Hennrikus, Eileen (Recipient), Horwitz, Alexandra (Recipient), Izer, Jenelle (Recipient), Jhaveri, Punit (Recipient), Kalantari, Annahieta (Recipient), Karpa, Kelly (Recipient), Kaur, Gurwant (Recipient), Keil, Ralph (Recipient), Khalid, M. Fahad (Recipient), Kimball, Scot (Recipient), Knoedler, John (Recipient), LaClair, Michelle (Recipient), Lam, Charlene (Recipient), LaRegina, Carol (Recipient), Lighthall, Jessyka (Recipient), Mailman, Richard (Recipient), McCormick, Jennifer (Recipient), McGinn, Johnathan (Recipient), McShane, Michael (Recipient), Millard, Roberta (Recipient), Myers, Abigail (Recipient), Nasir, Munima (Recipient), Oh, John (Recipient), Pathare, Aum (Recipient), Peterson, Brandon (Recipient), Potochny, John (Recipient), Roberts, S. Michael (Recipient), Romanoski, Natasha (Recipient), Ross, Stephen (Recipient), Rudnitsky, Gail (Recipient), Schade, Meredith (Recipient), Simmons, Zachary (Recipient), Smink, Gayle (Recipient), Stella, Salvatore (Recipient), Stephens, Mark (Recipient), Surapaneni, Sowmya (Recipient), Verbeek, Thomas (Recipient), Waning, David (Recipient), Williams, Emmanuelle (Recipient), Williams, Duane (Recipient), Wilson, Mary Ellen (Recipient), Zaorsky, Nicholas (Recipient) & Lutzkanin, Andrew (Recipient), 2020
Prize