Projects per year
Personal profile
Research interests
Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.
Teaching and educational interests
As part of her academic appointment and throughout her career, Dr. Deb Kelly has had the privilege of teaching and training the next generation of physician-scientists. Prior to joining Penn State, she mentored four medical students, four graduate students and numerous undergraduates. Her medical students have published their findings in peer-reviewed journals, contributing to 10 original research articles.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell Biology, Post-doctoral Training, Harvard Medical School
… → 2010
Molecular Biophysics, PhD, Florida State University
… → 2003
External positions
Vice Chair, Gordon Research Conference in Liquid Phase EM
2019
Director of Biological Sciences, Microscopy Society of America
Jan 1 2017 → …
Session Chair, Gordon Research Conference in 3D-EM
2017
Director of Biological Sciences, Microscopy Society of America
2017 → …
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Collaborations and top research areas from the last five years
Projects
- 9 Finished
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Collaborative Research: Infection mechanisms of bacteriophages targeting motile bacteria
Kelly, D. (PI)
6/1/21 → 5/31/24
Project: Research project
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Cryo-EM analysis of PI3K signaling complexes in glioblastoma
Sheng, Z. (PI) & Kelly, D. (CoPI)
12/1/19 → 11/30/21
Project: Research project
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Cyclic di-GMP Regulation of PilB in Motility and Biofilm
Yang, Z. Z. (PI) & Kelly, D. (CoPI)
8/1/19 → 7/31/23
Project: Research project
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Hot Spot Analysis of the Breast Cancer Susceptibility Protein
Kelly, D. (PI) & Kelly, D. F. (CoPI)
3/1/18 → 2/28/23
Project: Research project
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Erratum: Withdrawal notice to “Corrigendum to: 'Cryo-EM reveals architectural diversity in active Rotavirus particles'. Comput. Struct. Biotechnol. J. 2019 Jul 31; 17:1178-1183” [Comput. Struct. Biotechnol. J. 23 (2024) 3702, (S2001037024003441), (10.1016/j.csbj.2024.10.024)]
Hauser, M., Dearnaley, W. J., Varano, C., Casasanta, M., McDonald, S. M. & Kelly, D., Jan 2025, In: Computational and Structural Biotechnology Journal. 27, p. 57 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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CCK Receptor Inhibition Reduces Pancreatic Tumor Fibrosis and Promotes Nanoparticle Delivery
Abraham, T., Armold, M., McGovern, C., Harms, J. F., Darok, M. C., Gigliotti, C., Adair, B., Gray, J. L., Kelly, D. F., Adair, J. H. & Matters, G. L., May 2024, In: Biomedicines. 12, 5, 1024.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Corrigendum to “Cryo-EM reveals architectural diversity in active rotavirus particles” [Comput. Struct. Biotechnol. J. 17 (2019) 1178–1183, (S2001037019302259), (10.1016/j.csbj.2019.07.019)]
Hauser, M., Dearnaley, W. J., Varano, A. C., Casasanta, M., McDonald, S. M. & Kelly, D. F., Dec 2024, In: Computational and Structural Biotechnology Journal. 23, p. 3906 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Corrigendum to “Cryo-EM reveals architectural diversity in active rotavirus particles” [Comput Struct Biotechnol J 31 (17) (2019) 1178–1183, (S2001037019302259), (10.1016/j.csbj.2019.07.019)]
Hauser, M., Dearnaley, W. J., Varano, A. C., Casasanta, M., McDonald, S. M. & Kelly, D. F., Dec 2024, In: Computational and Structural Biotechnology Journal. 23, p. 3702 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Elucidating structural variability in p53 conformers using combinatorial refinement strategies and molecular dynamics
Solares, M. J., Dearnaley, W. J. & Kelly, D. F., 2024, In: Cancer Biology and Therapy. 25, 1, 2290732.Research output: Contribution to journal › Article › peer-review
Open Access