Projects per year
Personal profile
Research interests
Dr. Dhimant Desai’s research interest is to study the structural activity relationship of organic chemopreventive and chemotherapeutic agents against cancers of colon, lung, melanoma and leukemia. He specializes in micro- and macro-scale organic and bio-organic syntheses of carbocyclic nucleosides, carcinogens, chemopreventive and chemotherapeutic agents including organoselenium compounds, cytodifferentiating agents and nitric oxide inhibitors.
The focus of Dr. Desai's research is on the synthesis of carcinogenic polycyclic aromatic hydrocarbons, tobacco-specific N-nitrosamines and their metabolites and adducts. It further extends his research in animal bioassays (studies in mice, rats, hamsters); isotopic and radiochemical preparations; animal tissue distribution studies; and in vitro studies with synthetic standards, including 14C, 2H and 3H-labeled compounds.
Dr. Desai has focused on the prevention and treatment of colon cancer by selenium-containing COX-2 inhibitors. In another recently funded project, Dr. Desai has investigated PK/PD studies of PAN-antiviral agent in the treatment of HCMV infections. He is also involved in the research on gut microbiota and metabolomics studies with bile acid analogs in the treatment of non-fatty liver disease, COPD and asthma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Chemoprevention of colon cancer by a novel COX-2 inhibitor
Desai, D. (PI)
4/7/14 → 9/30/16
Project: Research project
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iNOS/Akt Inhibotor for Colon Cancer Chemoprevention
Desai, D. (PI)
6/9/09 → 5/31/10
Project: Research project
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Bile salt hydrolase catalyses formation of amine-conjugated bile acids
Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D. & Amin, S. & 10 others, , Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
The underappreciated diversity of bile acid modifications
Mohanty, I., Mannochio-Russo, H., Schweer, J. V., El Abiead, Y., Bittremieux, W., Xing, S., Schmid, R., Zuffa, S., Vasquez, F., Muti, V. B., Zemlin, J., Tovar-Herrera, O. E., Moraïs, S., Desai, D., Amin, S., Koo, I., Turck, C. W., Mizrahi, I., Kris-Etherton, P. M. & Petersen, K. & 8 others, , Mar 28 2024, In: Cell. 187, 7, p. 1801-1818.e20Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 2023, In: Laboratory Investigation. 103, 2, 100012.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Kale, V. P., Hengst, J. A., Sharma, A. K., Golla, U., Dovat, S., Amin, S. G., Yun, J. K. & Desai, D. H., Aug 2023, In: Pharmaceuticals. 16, 8, 1060.Research output: Contribution to journal › Article › peer-review
Open Access -
Complex chemical signals dictate Ah receptor activation through the gut-lung axis
Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Prizes
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize