Projects per year
Personal profile
Research interests
Dr. Dongxiao Sun's research interest is focused on small molecule analysis in different matrices by HPLC-MS/mass spectrometry as well as drug and carcinogen metabolism and pharmacogenetics study, including samples from cells, tissues, blood, urine, saliva, food, soil and many other sources.
The mass spectrometry systems in Dr. Sun's lab include Waters Acquity UPLC-Sciex 4000 QTRAP, Sciex ExionLC-Sciex QTRAP 6500+ and Sciex ExionLC-Sciex Q TOF 5600.
The Sun lab develops and validates method for each assay, including sample pretreatment, instrument performance and data process. Sample pretreatment includes solid-phase extraction, liquid-liquid extraction, etc., and the small molecules analyzed are in wide varieties, including amino acids, keto acids, steroids, vitamins, neurotransmitters, peptides, different drugs and their metabolites, carcinogens, natural compounds, synthetic compounds and many other biomarkers.
The lab also conducts metabolism pathway studies focused on phase I and phase II enzyme metabolizing of small molecules, especially for pharmacogenetics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Analytical Chemistry, PhD, The University of Hong Kong
1996 → 2002
Environmental Engineering, MS, East China University of Science and Technology
1991 → 1994
Applied Chemistry, BS, East China University of Science and Technology
… → 1991
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Collaborations and top research areas from the last five years
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Projects
- 2 Active
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Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
Muscat, J. (PI), Hobkirk, A. (CoPI), Sun, D. (CoPI), Richie, J. (CoPI), Foulds, J. (CoPI), Liao, J. (CoPI) & Spratt, T. (CoPI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/25
Project: Research project
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Biomarker and Analytical Chemistry Core
Richie, J. (PI) & Sun, D. (PI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/25
Project: Research project
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Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm-Petrels (Hydrobates leucorhous)
Lichtner, K. E., Dziubek, J. K., Joseph, N. A., Chapman, S. E., Chace, T. J., Sun, D., Bitzer, Z. T., Stier, A., Mauck, R. A., Jones, P. L. & Haussmann, M. F., 2025, (Accepted/In press) In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of benzo[a]pyrene-induced DNA adduct in buccal cells of smokers by black raspberry lozenges
Chen, K. M., Krebs, N. M., Sun, Y. W., Sun, D., Liao, J., Reinhart, L., Krzeminski, J., Amin, S., Stoner, G., Mallery, S. R. & El-Bayoumy, K., Jan 1 2025, In: Carcinogenesis. 46, 1, bgae067.Research output: Contribution to journal › Article › peer-review
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Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis
Tang, M., Dirks, K., Kim, S. Y., Qiu, Z., Gao, Y., Sun, D., Peruggia, G., Sallavanti, J. & Li, W., Apr 2025, In: Cell Death and Differentiation. 32, 4, p. 598-612 15 p., 2700.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Intraperitoneal delivery of cannabidiol (CBD) and Δ9-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice
Brendle, S. A., Li, J., Sun, D., Zhu, J., Henderson-Redmond, A. N., Morgan, D., Balogh, K. K., Covington, D., Shearer, D. A. & Hu, J., Jun 2025, In: Tumour Virus Research. 19, 200307.Research output: Contribution to journal › Article › peer-review
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Temporal Dynamics of Smoking Urges: Investigating Morning Cravings, Nicotine Dependence, and Smoking Behaviors
Branstetter, S. A., Krebs, N. M., Chen, A., Sun, D., Zhu, J. & Muscat, J. E., 2025, (Accepted/In press) In: Substance Use and Misuse.Research output: Contribution to journal › Article › peer-review
Open Access