Personal profile
Research interests
Dr. Dongxiao Sun's research interest is focused on small molecule analysis in different matrices by HPLC-MS/mass spectrometry as well as drug and carcinogen metabolism and pharmacogenetics study, including samples from cells, tissues, blood, urine, saliva, food, soil and many other sources.
The mass spectrometry systems in Dr. Sun's lab include Waters Acquity UPLC-Sciex 4000 QTRAP, Sciex ExionLC-Sciex QTRAP 6500+ and Sciex ExionLC-Sciex Q TOF 5600.
The Sun lab develops and validates method for each assay, including sample pretreatment, instrument performance and data process. Sample pretreatment includes solid-phase extraction, liquid-liquid extraction, etc., and the small molecules analyzed are in wide varieties, including amino acids, keto acids, steroids, vitamins, neurotransmitters, peptides, different drugs and their metabolites, carcinogens, natural compounds, synthetic compounds and many other biomarkers.
The lab also conducts metabolism pathway studies focused on phase I and phase II enzyme metabolizing of small molecules, especially for pharmacogenetics.
Education/Academic qualification
Analytical Chemistry, PhD, The University of Hong Kong
1996 → 2002
Environmental Engineering, MS, East China University of Science and Technology
1991 → 1994
Applied Chemistry, BS, East China University of Science and Technology
… → 1991
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Biomarker and Analytical Chemistry Core
Richie, J. (PI) & Sun, D. (PI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/26
Project: Research project
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Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
Muscat, J. (PI), Hobkirk, A. (CoPI), Sun, D. (CoPI), Richie, J. (CoPI), Foulds, J. (CoPI), Liao, J. J. (CoPI) & Spratt, T. (CoPI)
NATIONAL INSTITUTE ON DRUG ABUSE
9/30/23 → 8/31/26
Project: Research project
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Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma
Li, Y., Li, Z., Li, Q., Sun, D., Ni, B., Tan, M., Shay, A., Wang, M., Meng, C., Shen, G., Fu, B., Shan, Y., Zhang, S., Tanshee, R. R., Zhou, T., Xie, Y., Chen, K. M., Qiao, B., Dang, Y. & Kimball, S. & 6 others, , Dec 2026, In: Nature communications. 17, 1, 1343.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Angelica herbal supplement AGN-Cogni.Q acute dose safety and pharmacokinetics (PK) dose-response in prostate cancer patients.
Joshi, M., Fan, T., Schell, T. D., Liu, X., Perimbeti, S., Wheelden, M., Sun, D., Desai, D., Shank, D., Strong, A. L., Raman, J. D., Liao, J., Jiang, C. & Lu, J., Mar 2026, In: Journal of Clinical Oncology. 44, p. 372 1 p.Research output: Contribution to journal › Article › peer-review
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Anti-Biofilm Properties of Polyurethane Biomaterials Tethered With Small Molecules via Polyethylene Glycol Linker
Liu, J., Chen, C., Booth, J. L., Lanza, M., Sun, D., Allcock, H. R., Siedlecki, C. A. & Xu, L. C., Apr 2026, In: Journal of Biomedical Materials Research - Part A. 114, 4, e70069.Research output: Contribution to journal › Article › peer-review
Open Access -
Coenzyme A mitigates cystine-deprivation-induced ferroptosis by suppressing the iron-starvation response
Tan, M., Li, Y., Sang, L., Wang, M., Li, Q., Li, Z., Sun, D., Wang, X. & Yang, S., 2026, (Accepted/In press) In: FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Ergothioneine dynamics in a long-term farming systems trial: Effects of tillage, management, and oxidative stress on grain and soil ergothioneine
Das, S., Omondi, E. C., Hinson, P. O., Nguyen, K. D., Olson, R., Beelman, R., Bitzer, Z., Sun, D., Zinati, G., Smith, A. & Fagan, J., Mar 2026, In: Journal of Agriculture and Food Research. 26, 102661.Research output: Contribution to journal › Article › peer-review
Open Access