Projects per year
Personal profile
Research interests
The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Projects
- 3 Finished
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The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus
Chalmers, F. E., Mogre, S., Rimal, B., Son, J., Patterson, A. D., Stairs, D. B. & Glick, A. B., Dec 2022, In: Developmental biology. 492, p. 59-70 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l] pyrene diol epoxide
Stairs, D. B., Landmesser, M. E., Aliaga, C., Chen, K. M., Sun, Y. W. & El-Bayoumy, K., Nov 2021, In: PloS one. 16, 11 November, e0259998.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression
Teye, E. K., Lu, S., Chen, F., Yang, W., Abraham, T., Stairs, D. B., Wang, H. G., Yochum, G. S., Brodsky, R. A. & Pu, J. J., Dec 2021, In: Scientific reports. 11, 1, 19022.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections
Christensen, N. D., Chen, K. M., Hu, J., Stairs, D. B., Sun, Y. W., Aliaga, C., Balogh, K. K., Atkins, H., Shearer, D., Li, J., Brendle, S. A., Gowda, K., Amin, S., Walter, V., Viscidi, R. & El-Bayoumy, K., Jan 5 2021, In: Chemico-Biological Interactions. 333, 109321.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis
El-Bayoumy, K., Christensen, N. D., Hu, J., Viscidi, R., Stairs, D. B., Walter, V., Chen, K. M., Sun, Y. W., Muscat, J. E. & Richie, J. P., Aug 1 2020, In: Cancer Prevention Research. 13, 8, p. 649-660 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations