Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Edward P. O'Brien, Jr. is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Machine Learning Guided Biophysical Model Development of Amino Acid and tRNA Effects on Translation-Elongation Speed
1/1/21 → 12/31/23
Project: Research project
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Translation Kinetics and their Effects on Protein Structure and Function, mRNA half-lives, and Cellular Phenotype
O'Brien, Jr., E. P. & O'brien, E. E. P.
National Institute of General Medical Sciences
8/1/17 → 7/31/24
Project: Research project
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MoCeIS-DCL: Planning Workshops for Synthesis of Massively Parallel Assays and Molecular Physiology
O'Brien, Jr., E. P., Lareau, L. L., Marqusee, S. S., Shah, P. P. & Thirumalai, D.
9/1/21 → 8/31/22
Project: Research project
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Conference: Protein Folding on the Ribosome
O'Brien, Jr., E. P. & Kaiser, C. C.
8/1/20 → 7/31/22
Project: Research project
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CC* Team: Research Innovation with Scientists and Engineers (RISE)
Hanna, C. R., O'Brien, Jr., E. P. & Evans, J.
7/1/20 → 6/30/23
Project: Research project
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How soluble misfolded proteins bypass chaperones at the molecular level
Halder, R., Nissley, D. A., Sitarik, I., Jiang, Y., Rao, Y., Vu, Q. V., Li, M. S., Pritchard, J. & O’Brien, E. P., Dec 2023, In: Nature communications. 14, 1, 3689.Research output: Contribution to journal › Article › peer-review
Open Access -
How synonymous mutations alter enzyme structure and function over long timescales
Jiang, Y., Neti, S. S., Sitarik, I., Pradhan, P., To, P., Xia, Y., Fried, S. D., Booker, S. J. & O’Brien, E. P., Mar 2023, In: Nature Chemistry. 15, 3, p. 308-318 11 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study
Vu, Q. V., Nissley, D. A., Jiang, Y., O’Brien, E. P. & Li, M. S., Jun 1 2023, In: Journal of Physical Chemistry B. 127, 21, p. 4761-4774 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments
Zhao, B., Rao, Y., Leighow, S., O’Brien, E. P., Gilbert, L. & Pritchard, J. R., Dec 2022, In: Nature communications. 13, 1, 625.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing Ability
Nguyen, H., Lan, P. D., Nissley, D. A., O'Brien, E. P. & Li, M. S., Apr 21 2022, In: Journal of Physical Chemistry B. 126, 15, p. 2812-2823 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations