Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Center: National Synthesis Center for Emergence in the Molecular and Cellular Sciences
O'Brien, Jr., E. P. (PI) & Honavar, V. G. (CoPI)
5/1/24 → 4/30/29
Project: Research project
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Translation Kinetics and their Effects on Protein Structure and Function, mRNA half-lives, and Cellular Phenotype
O'Brien, Jr., E. P. (PI) & O'brien, E. E. P. (CoPI)
National Institute of General Medical Sciences
8/1/17 → 7/31/26
Project: Research project
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MoCeIS-DCL: Planning Workshops for Synthesis of Massively Parallel Assays and Molecular Physiology
O'Brien, Jr., E. P. (PI), Thirumalai, D. (CoPI), Marqusee, S. S. (CoPI), Shah, P. (CoPI) & Lareau, L. L. (CoPI)
9/1/21 → 8/31/22
Project: Research project
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Machine Learning Guided Biophysical Model Development of Amino Acid and tRNA Effects on Translation-Elongation Speed
O'Brien, Jr., E. P. (PI)
1/1/21 → 12/31/24
Project: Research project
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Conference: Protein Folding on the Ribosome
O'Brien, Jr., E. P. (PI) & Kaiser, C. C. (CoPI)
8/1/20 → 7/31/22
Project: Research project
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A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality
Sitarik, I., Vu, Q. V., Petucci, J., Frutos, P., Song, H. & O’Brien, E. P., Dec 2025, In: Nature communications. 16, 1, 10870.Research output: Contribution to journal › Article › peer-review
Open Access -
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Lentzsch, A. M., Fan, Z., Irshad, I. U., O’Brien, E. P., Sharma, A. K., Green, R. & Shan, S. O., Dec 18 2025, In: Molecular cell. 85, 24, p. 4562-4574.e6Research output: Contribution to journal › Article › peer-review
Open Access -
Noncovalent Lasso Entanglements are Common in Experimentally Derived Intrinsically Disordered Protein Ensembles and Strongly Influenced by Protein Length and Charge
Vu, Q. V., Sitarik, I., Li, M. S. & O’Brien, E. P., May 15 2025, In: Journal of Physical Chemistry B. 129, 19, p. 4682-4691 10 p.Research output: Contribution to journal › Article › peer-review
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Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles
Vu, Q. V., Sitarik, I., Jiang, Y., Xia, Y., Sharma, P., Yadav, D., Song, H., Li, M. S., Fried, S. D. & O'Brien, E. P., Aug 8 2025, In: Science Advances. 11, 32, p. 1-11 11 p., eadt8974.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Properties Governing Native State Entanglements and Relationships to Protein Function
Petucci, J., Sitarik, I., Jiang, Y., Rana, V., Song, H. & O'Brien, E. P., Oct 1 2025, In: Journal of Molecular Biology. 437, 19, 169342.Research output: Contribution to journal › Article › peer-review
Open Access