Dr. Emmanuelle Williams committed to combining her medical aspirations with education after her experience teaching at a boarding school following her college graduation. She has been involved in educational initiatives ever since her arrival at Penn State. Dr. Williams has been the course director for the second-year gastroenterology course, the gastroenterology clinical elective rotation and, since 2013, the co-director of the Problem-Based Learning (PBL) curriculum. A more recent interest for Dr. Williams has been in the area of wellness and burnout. She has been a representative for the Division of Gastroenterology and for the Department of Medicine on a campus-wide level for wellness initiatives.

In July 2019, Dr. Williams became the Associate Dean for Student Affairs for the College of Medicine's MD Program. In that role, she will engage with students in all phases of the curriculum leading to the completion of the medical degree to guide them in their development as physicians, in the achievement of the College's competencies, and in finding their paths to their career goals.

Dr. Emmanuelle Williams' clinical work has focused almost exclusively on the care of patients with Inflammatory Bowel Disease (IBD).  In conjunction with Dr. Walter Koltun, she helped establish the Penn State Inflammatory Bowel Disease Center in 2013.  Since then, the center has grown its patient population exponentially and achieved national recognition for quality care, clinical innovations and research.