Projects per year
Personal profile
Research interests
The laboratory of Dr. Fadia Kamal studies cellular pathways that control chondrocyte homeostasis in healthy tissue and the key processes that transform them to pathological cells, which leads to cartilage damage and loss in osteoarthritis.
Osteoarthritis is a debilitating disease with no disease-modifying treatment available. Osteoarthritis is characterized by continuous and progressive cartilage loss leading to joint dysfunction. Chondrocyte, the functional cell of cartilage controls cartilage homeostasis by secreting cartilage matrix components and matrix degrading enzymes. In osteoarthritis, the chondrocyte acquires an aberrant phenotype, it differentiates to become hypertrophic and secretes higher levels of matrix degrading enzymes, ultimately leading to cartilage matrix degradation and cartilage loss.
The Kamal lab’s research focuses on discovering new pathways and drugs that target these disease pathways, and control chondrocyte behavior to delay or even reverse osteoarthritis disease process.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Therapeutic targeting of GPCR Gbetagamma-GRK2 in osteoarthritis
Kamal, F. (PI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2/21/19 → 12/31/23
Project: Research project
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Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice
Khajuria, D. K., Karuppagounder, V., Nowak, I., Sepulveda, D. E., Lewis, G. S., Norbury, C. C., Raup-Konsavage, W. M., Vrana, K. E., Kamal, F. & Elbarbary, R. A., Nov 2023, In: Journal of Bone and Mineral Research. 38, 11, p. 1560-1576 17 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity
Khajuria, D. K., Reider, I., Kamal, F., Norbury, C. C. & Elbarbary, R. A., 2023, In: Frontiers in immunology. 14, 1250309.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis
Karuppagounder, V., Chung, J., Abdeen, A., Thompson, A., Bouboukas, A., Pinamont, W. J., Yoshioka, N. K., Sepulveda, D. E., Raup-Konsavage, W., Graziane, N. M., Vrana, K., Elbarbary, R. & Kamal, F., Dec 1 2023, In: Cannabis and Cannabinoid Research. 8, 6, p. 1030-1044 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing
Khajuria, D. K., Nowak, I., Leung, M., Karuppagounder, V., Imamura, Y., Norbury, C. C., Kamal, F. & Elbarbary, R. A., Dec 2023, In: Bone Research. 11, 1, 5.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Wee, H., Khajuria, D. K., Kamal, F., Lewis, G. S. & Elbarbary, R. A., Dec 2022, In: Journal of Visualized Experiments. 2022, 190, e64262.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Prizes
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Samuel Hinkle Junior Faculty Research Scholar Award
Proctor, E. A. (Recipient) & Kamal, F. (Recipient), 2022
Prize