Projects per year
Personal profile
Research interests
Dr. George-Lucian Moldovan’s major research goal is to elucidate the molecular mechanism of replication of DNA lesions in human cells, using an integrative approach that includes:
- identification of the factors involved in detection and processing of stalled forks;
- biochemical reconstitution of discrete steps of the fork restart process; and
- genetic analyses to assess the role of these processes in genomic stability, cellular transformation, and cancer prevention and therapy.
For all organisms, the information necessary for living and propagation is encoded in their genomes. Maintaining and transferring stable genomes to the progeny is thus essential. In humans, failure to preserve the correct DNA sequence can result in cellular transformation and cancer, as well as degeneration and accelerated aging. To avoid genomic instability, cells employ numerous mechanisms that detect, signal and repair DNA lesions. These mechanisms also stabilize and protect complex macromolecular structures such as replication forks (which form during DNA duplication) and ensure the correct and timely replication and segregation of chromosomes. They are subjected to complex cellular regulation and are frequently inactivated in cancer.
In particular, DNA replication is a complex process that requires tight regulation to ensure genomic stability. Replication of damaged DNA poses a great risk, since DNA lesions cannot be processed by regular replicative polymerases and thus result in stalling of the replication machinery. Understanding how the replication machinery deals with roadblocks is fundamental, since prolonged replication stalling can result in strand breaks, translocations, and genomic instability. What ultimately dictates the fate of stalled forks is not understood and in fact remains one of the biggest unsolved mysteries in cell biology.
To resolve this conundrum, the missing components of this regulatory circuit must be identified and characterized.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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The Role of Mono-ADP-Ribosylation by PARP14 in Radioresistance
National Institute of Environmental Health Sciences
2/1/16 → 12/31/23
Project: Research project
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The role of DNA damage tolerance pathways in human cells
Bielinsky, A. K., Moldovan, G. & Moldovan, G. G. L.
National Institute of General Medical Sciences
8/14/19 → 5/31/23
Project: Research project
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The PCNA-PARI Pathway of Genome Stability in Cancer
Congressionally Directed Medical Research Programs
9/15/15 → 9/14/18
Project: Research project
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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
Wang, Y. C., Kelso, A. A., Karamafrooz, A., Chen, Y. H., Chen, W. K., Cheng, C. T., Qi, Y., Gu, L., Malkas, L., Taglialatela, A., Kung, H. J., Moldovan, G. L., Ciccia, A., Stark, J. M. & Ann, D. K., Apr 25 2023, In: Cell Reports. 42, 4, 112296.Research output: Contribution to journal › Article › peer-review
Open Access -
ADP-ribosyltransferases, an update on function and nomenclature
Lüscher, B., Ahel, I., Altmeyer, M., Ashworth, A., Bai, P., Chang, P., Cohen, M., Corda, D., Dantzer, F., Daugherty, M. D., Dawson, T. M., Dawson, V. L., Deindl, S., Fehr, A. R., Feijs, K. L. H., Filippov, D. V., Gagné, J. P., Grimaldi, G., Guettler, S., Hoch, N. C., & 27 others , Dec 2022, In: FEBS Journal. 289, 23, p. 7399-7410 12 p.Research output: Contribution to journal › Article › peer-review
Open Access104 Scopus citations -
Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival
Khatib, J. B., Schleicher, E. M., Jackson, L. M., Dhoonmoon, A., Moldovan, G. L. & Nicolae, C. M., 2022, In: Oncotarget. 13, 1, p. 1078-1091 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery
Schleicher, E. M. & Moldovan, G. L., Dec 2022, In: FEBS Journal. 289, 24, p. 7854-7868 15 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling
Thakar, T., Dhoonmoon, A., Straka, J., Schleicher, E. M., Nicolae, C. M. & Moldovan, G. L., Dec 2022, In: Nature communications. 13, 1, 5323.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Prizes
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Dean's Award for Excellence in Teaching
Aprile, Bettina (Recipient), Bezinover, Dmitri (Recipient), Blackall, George (Recipient), Booth, Jennifer (Recipient), Buchkovich, Nicholas (Recipient), Budde, Arne (Recipient), Burns, Amy (Recipient), Cartee, Todd (Recipient), Chu, David C. (Recipient), Cilley, Robert (Recipient), Crook, Tonya (Recipient), Dalke, Katharine (Recipient), Dambro, Anthony (Recipient), De Jesus, Sol (Recipient), Demetriou, Theodore (Recipient), DeWaters, Ami (Recipient), Duca, Nicholas (Recipient), Evey, Loren (Recipient), Frauenhoffer, Elizabeth (Recipient), Garner, Matthew (Recipient), Glass, Kristen (Recipient), Goyal, Neerav (Recipient), Grine, Kristen (Recipient), Habib, Sabeen (Recipient), Irby, Rosalyn (Recipient), Jones, Edward (Recipient), June, Rayford (Recipient), Karamchandani, Kunal (Recipient), Karpa, Kelly (Recipient), Kasmire, Kathryn (Recipient), Katzman, Michael (Recipient), Kavanagh, Robert (Recipient), Kees-Folts, Deborah (Recipient), Kesterson, Joshua (Recipient), Sciacca Kirby, Joslyn (Recipient), Kresch, Mitchell (Recipient), Lankford, Edward (Recipient), McDonald, Alicia (Recipient), Miller, Ronald (Recipient), Moldovan, George-Lucian (Recipient), Myler, Conrad (Recipient), Nelson, Amanda (Recipient), Neutze, Janet (Recipient), Newell, Jordan (Recipient), Norbury, Christopher (Recipient), O'Hara, Christopher (Recipient), Palmer, Timothy (Recipient), Pantanelli, Seth (Recipient), Pichardo-Lowden, Ariana (Recipient), Po, Wilson (Recipient), Radico, Julie (Recipient), Radtka, John (Recipient), Razeghi, Sanam (Recipient), Rodgers, Ross (Recipient), Romanoski, Natasha (Recipient), Samson, Thomas (Recipient), Shantz, Lisa (Recipient), Smith, Brandon (Recipient), Stephens, Mark (Recipient) & Wang, Ming (Recipient), 2019
Prize
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Dean’s Award for Excellence in Teaching
Hollins, L. Claire (Recipient), Nisnevitch-Savarese, Zoulfira (Recipient), Read, Selina (Recipient), Rossi, John (Recipient), Royo, Marc (Recipient), Sarraf, Elie (Recipient), Shah, Bunty (Recipient), Moldovan, George-Lucian (Recipient), van Riggelen, Jan (Recipient), Shantz, Lisa (Recipient), Yengo, Christopher (Recipient), Booth, Jennifer (Recipient), Bates, Erica (Recipient), Schuster, Angel (Recipient), Clebak, Karl (Recipient), Daniels, Eldra W. (Recipient), Hays, Amy (Recipient), Hemerly, Nathan (Recipient), Thompson, Andrew (Recipient), George, Daniel (Recipient), Evey, Loren (Recipient), McLaughlin, Patricia (Recipient), Acharya, Jayant (Recipient), De Jesus, Sol (Recipient), O'Leary, Amber (Recipient), Wright, Tonya (Recipient), Cantore, William (Recipient), Pantanelli, Seth (Recipient), Millard, Roberta (Recipient), Updegrove, Gary F. (Recipient), Choi, Karen (Recipient), Darowish, Charles (Recipient), Dooley, Amy (Recipient), Hackman, Nicole (Recipient), Krawiec, Conrad (Recipient), Oji-Mmuo, Christiana (Recipient), Ryan, Sheryl (Recipient), Shedlock, Aaron (Recipient), Tunks, Robert (Recipient), Critchfield, Laura (Recipient), Bellon, Alfredo (Recipient), Dougherty, Kathleen (Recipient), Lagman, Jasmin (Recipient), Mahgoub, Yassir (Recipient), Dreibelbis, Tomi (Recipient), Richie, John (Recipient), Wang, Li (Recipient), Methratta, Sosamma (Recipient), Chauvin, Nancy (Recipient), Deutsch, Michael (Recipient), Kulaylat, Afif (Recipient), Paulishak, Melody (Recipient), Staszak, Ryan (Recipient) & MacDonald, Susan (Recipient), 2022
Prize
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Outstanding Collaborative Research Team
Aird, Katherine (Recipient), Baker, Maria (Recipient), Hempel, Nadine (Recipient), Hossler, Carrie (Recipient), Kesterson, Joshua (Recipient), Moldovan, George-Lucian (Recipient), Newell, Jordan (Recipient), Phaeton, Rebecca (Recipient), Rosenberg, Jennifer (Recipient), Walter, Vonn (Recipient), Warrick, Joshua (Recipient), Badzek, Laurie (Recipient), Foy, Andrew (Recipient), Green, Michael (Recipient), Levi, Benjamin (Recipient) & Van Scoy, Lauren (Recipient), 2020
Prize
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