Projects per year
Personal profile
Research interests
Dr. Gregory Lewis' research program focuses on orthopaedic biomechanics, with an emphasis on bone, joints and surgical procedures including fracture fixation and shoulder replacement. A major program area is the development of surgeon-targeted software platforms for education and preoperative planning.
The lab has built large simulation libraries of fracture fixation constructs having different implant types, geometries, materials, fracture geometries and bone quality. Computational finite element simulations are used to predict clinically important biomechanics that influence fracture healing and postoperative complications. An innovative, interactive software is being developed for visualizing these biomechanics.
For surgical education, these efforts are currently funded by an NIH R01. For preoperative planning, the group is modifying its approaches to include patient-specific models derived from CT imaging.
Experimental validation using cadaver specimens, and rigorous software testing with surgeons, are also important parts of the research.
Dr. Lewis’s lab has strong collaborations with orthopaedic surgeons, musculoskeletal biologists and other engineers. He is a co-investigator on several NIH R01 projects studying bone biology and regeneration. He provides expertise in bone quality assessment through micro-computed tomography imaging and mechanical testing. He also provides expertise related to in vivo mechanical loading in animal models.
In the area of shoulder replacement biomechanics, Dr. Lewis and collaborators are investigating the multiscale mechanics of glenoid component fixation. The lab has had industry support for several other biomechanical projects.
Dr. Lewis is director of the micro-CT core and the research thrust leader for Penn State Center for Biodevices.
Teaching and educational interests
Dr. Gregory Lewis directs the Center for Orthopaedic Research and Translational Science's basic science curriculum for orthopaedic residents.
Dr. Lewis also serves as an adviser for medical student research projects, is an instructor for the senior undergraduate capstone design course in mechanical engineering at Penn State Harrisburg and provides other lectures to students at three campuses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
CAREER: Structures and Properties of Bone at Multiple Length Scales
Du, J. (CoPI) & Lewis, G. (PI)
1/1/22 → 12/31/26
Project: Research project
-
Biomedical Engineering Design: Integrating Simulation, Clinical Immersion, and Regulatory Training
Lewis, G. (PI) & Hayes, D. J. (CoPI)
National Institute of Biomedical Imaging and Bioengineering
9/23/21 → 6/30/27
Project: Research project
-
Fracture Fixation Biomechanics Simulator with Adaptive Virtual Coaching
Lewis, G. (PI) & Reid, J. S. (CoPI)
National Institute of Biomedical Imaging and Bioengineering
5/1/20 → 1/31/24
Project: Research project
-
A Biomechanical Comparison of Three Current Scapholunate Reconstruction Methods
Pilla, N. I., Koroneos, Z. A., Dunleavy, M. L., Vaughn, N. H., Lewis, G. S. & Payatakes, A. H., May 2025, In: Journal of Hand Surgery Global Online. 7, 3, 100701.Research output: Contribution to journal › Article › peer-review
-
Dynamic Fracture Fixation Plates: A Systematic Review of Evolving Design Approaches
Huxman, C., Armstrong, A., Updegrove, G., Lewis, G. S. & Butler, J., Jun 2025, In: Annals of Biomedical Engineering. 53, 6, p. 1271-1290 20 p., 593448.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Effects of Plate-Bone Contact on Bridge Plate Fracture Fixation Biomechanics: Computational, Experimental, and Analytical Modeling
Koroneos, Z. A., Wee, H., Reid, J. S. & Lewis, G., 2025, (Accepted/In press) In: Journal of Orthopaedic Research.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study
Huxman, C., Lewis, G., Armstrong, A., Updegrove, G., Koroneos, Z. & Butler, J., Jan 2025, In: Journal of Orthopaedic Research. 43, 1, p. 217-227 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A FLEXIBLE PATELLA FRACTURE DEVICE FOR INCREASED ANTERIOR CORTICAL COMPRESSION
Huxman, C., Updegrove, G., Armstrong, A., Lewis, G. & Butler, J., 2024, Proceedings of the 2024 Design of Medical Devices Conference, DMD 2024. American Society of Mechanical Engineers (ASME), V001T09A011. (Proceedings of the 2024 Design of Medical Devices Conference, DMD 2024).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution