Projects per year
Personal profile
Research interests
Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute
1993 → 1997
PhD, University of Tsukuba
1987 → 1992
BS, University of Tsukuba
1983 → 1987
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Collaborations and top research areas from the last five years
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. G., Cabot, M. C., Claxton, D., Fox, T. E., Kester, M., Liao, J., Loughran, T. P., Wang, H., Loughran, T. T. P., Horton, B. B. J., Chalfant, C. C. E., Conaway, M., Janes, K. A. & Cabot, M. M. C.
9/10/13 → 5/31/24
Project: Research project
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Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis
Liu, Z., Spiegelman, V. S. & Wang, H. G., Oct 2022, In: Cancer Reports. 5, 10, e1592.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation
Zhou, S., Liu, X., Fang, X., Chinchilli, V. M., Wang, M., Wang, H. G., Dokholyan, N. V., Shen, C. & Lee, J. J., Aug 2022, In: eLife. 11, e78634.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy
Liu, X., Wills, C. A., Chen, L., Zhang, J., Zhao, Y., Zhou, M., Sundstrom, J. M., Schell, T., Spiegelman, V. S., Young, M. M. & Wang, H. G., Apr 28 2022, In: Journal for ImmunoTherapy of Cancer. 10, 4, e004399.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
Hirschler-Laszkiewicz, I., Festa, F., Huang, S., Moldovan, G. L., Nicolae, C., Dhoonmoon, A., Bao, L., Keefer, K., Chen, S. J., Wang, H. G., Cheung, J. Y. & Miller, B. A., Dec 2022, In: Scientific reports. 12, 1, 6311.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
The human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression
Bao, L., Festa, F., Hirschler-Laszkiewicz, I., Keefer, K., Wang, H. G., Cheung, J. Y. & Miller, B. A., Dec 2022, In: Scientific reports. 12, 1, 20544.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Prizes
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Career Citation Milestone Award - D (500) Club
Broach, James (Recipient), Coates, Matthew (Recipient), Duffy, Charles (Recipient), Gardner, Andrew (Recipient), Gill, Donald (Recipient), Helm, Klaus (Recipient), Kimball, Scot (Recipient), Leslie, Douglas (Recipient), Lipton, Allan (Recipient), Ma, Thomas (Recipient), Naccarelli, Gerald (Recipient), Schmitz, Kathryn (Recipient), Siedlecki, Christopher (Recipient), Stoute, Jose (Recipient), Tombran-Tink, Joyce (Recipient) & Wang, Hong-Gang (Recipient), 2020
Prize
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Career Citation Milestone Award - D (500) Club
Barber, Alistair (Recipient), Belani, Chandra (Recipient), Bixler, Edward (Recipient), Eslinger, Paul (Recipient), Imamura, Yuka (Recipient), Legro, Richard (Recipient), Mailman, Richard (Recipient), Schiff, Steven (Recipient), Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2019
Prize
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Career Citation Milestone Award - D (500) Club
Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2017
Prize
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Outstanding Collaborative Research Team
Adair, James Hansell (Recipient), Amin, Shantu (Recipient), Claxton, David (Recipient), Desai, Dhimant (Recipient), Hengst, Jeremy (Recipient), Liao, Jiangang "Jason" (Recipient), Paulson, Robert (Recipient), Sharma, Arun (Recipient), Stanley, Bruce (Recipient), Wang, Hong-Gang (Recipient), Yun, Jong (Recipient) & Zhu, Junjia (Recipient), 2015
Prize