Projects per year
Personal profile
Research interests
Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute
1993 → 1997
PhD, University of Tsukuba
1987 → 1992
BS, University of Tsukuba
1983 → 1987
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Collaborations and top research areas from the last five years
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. (CoPI), Cabot, M. C. (CoPI), Claxton, D. (CoPI), Fox, T. E. (CoPI), Kester, M. (CoPI), Liao, J. (CoPI), Loughran, T. P. (CoPI), Wang, H.-G. (CoPI), Horton, B. B. J. (CoPI), Chalfant, C. C. E. (CoPI), Conaway, M. (CoPI) & Janes, K. A. (CoPI)
9/10/13 → 5/31/25
Project: Research project
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Targeting Sphingosine Kinase in AML
Kester, M. (CoPI) & Wang, H.-G. (PI)
9/10/13 → 8/31/18
Project: Research project
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Regulation of Autophagy and Tumorigenesis by Bif-1
Wang, H.-G. (PI) & Wang, H.-G. (CoPI)
4/1/09 → 1/31/15
Project: Research project
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Apoptosis Mechanisms and Human Cancer
Wang, H.-G. (CoPI) & Wang, H.-G. (PI)
8/1/99 → 3/31/17
Project: Research project
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Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis
Wills, C. A., Liu, X., Chen, L., Zhao, Y., Liu, Z., Spiegelman, V. S., Sundstrom, J. & Wang, H. G., Jul 2024, In: Genes and Diseases. 11, 4, 101017.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Hattori, T., Fundora, K. A., Hamamoto, K., Opozda, D. M., Liang, X., Liu, X., Zhang, J., Uzun, Y., Takahashi, Y. & Wang, H. G., 2024, In: Autophagy. 20, 2, p. 349-364 16 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure
Ye, Y., Liang, X., Wang, G., Bewley, M. C., Hamamoto, K., Liu, X., Flanagan, J., Wang, H.-G., Takahashi, Y. & Tian, F., Dec 2024, In: Communications Biology. 7, 1, 334.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma
Lu, T., Yee, P. P., Chih, S. Y., Tang, M., Chen, H., Aregawi, D. G., Glantz, M. J., Zacharia, B. E., Wang, H.-G. & Li, W., Jul 1 2024, In: EMBO Journal. 43, 13, p. 2582-2605 24 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy
Ye, Y., Bewley, M. C., Wang, H. G., Tian, F. & Flanagan, J. M., 2024, In: Autophagy. 20, 3, p. 709-711 3 p.Research output: Contribution to journal › Article › peer-review
Prizes
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Career Citation Milestone Award - D (500) Club
Broach, J. (Recipient), Coates, M. (Recipient), Duffy, C. (Recipient), Gardner, A. (Recipient), Gill, D. (Recipient), Helm, K. (Recipient), Kimball, S. (Recipient), Leslie, D. (Recipient), Lipton, A. (Recipient), Ma, T. (Recipient), Naccarelli, G. (Recipient), Schmitz, K. (Recipient), Siedlecki, C. (Recipient), Stoute, J. (Recipient), Tombran-Tink, J. (Recipient) & Wang, H.-G. (Recipient), 2020
Prize
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Career Citation Milestone Award - D (500) Club
Barber, A. (Recipient), Belani, C. (Recipient), Bixler, E. (Recipient), Eslinger, P. (Recipient), Imamura, Y. (Recipient), Legro, R. (Recipient), Mailman, R. (Recipient), Schiff, S. (Recipient), Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2019
Prize
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Career Citation Milestone Award - D (500) Club
Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2017
Prize
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize