Personal profile
Research interests
Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.
Education/Academic qualification
Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute
1993 → 1997
PhD, University of Tsukuba
1987 → 1992
BS, University of Tsukuba
1983 → 1987
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Targeting extracellular vesicles in neuroblastoma
Spiegelman, V. (PI) & Wang, H.-G. (CoPI)
8/11/25 → 7/31/26
Project: Research project
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Autophagy Heterogeneity and Tumor Metastasis
Wang, H.-G. (PI)
4/1/21 → 3/31/23
Project: Research project
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Non-canonical Caspase-8 Activation on Autophagosomal Membranes
Wang, H.-G. (PI)
8/1/18 → 1/31/26
Project: Research project
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Targeting Sphingosine Kinase in AML
Kester, M. (CoPI) & Wang, H.-G. (PI)
9/10/13 → 8/31/18
Project: Research project
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. (CoPI), Cabot, M. C. (CoPI), Claxton, D. F. (CoPI), Fox, T. E. (CoPI), Kester, M. (CoPI), Liao, J. (CoPI), Loughran, T. P. (CoPI), Wang, H.-G. (CoPI), Horton, B. B. J. (CoPI), Chalfant, C. C. E. (CoPI), Conaway, M. (CoPI) & Janes, K. A. (CoPI)
9/10/13 → 5/31/25
Project: Research project
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Cutting edge: ESCRT-mediated phagophore closure in mammals
Takahashi, Y., Opozda, D. M. & Wang, H. G., May 2026, In: Biochemical Journal. 483, 5, p. 741-759 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Establishment of Patient-Derived Organoids for Pediatric Cancer Research
Younis, M., Arjmandi, T., Haque, M., McClain, K., Walter-Angelo, T., Back, F., Gandra, D., Moore, A., Behura, C., Spiegelman, V. S., Wang, H.-G., Dovat, S., Hengst, J. & Sholler, G. S., May 2026, In: Cancers. 18, 9, 1465.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth
Zhang, R., Chen, L., Liang, X., Zhang, J., Hamamoto, K., Hattori, T., Vangala, V., Schell, T. D., Saulnier Sholler, G., Takahashi, Y. & Wang, H.-G., 2026, (Accepted/In press) In: Oncogene.Research output: Contribution to journal › Article › peer-review
Open Access -
Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Bui, V., Liang, X., Ye, Y., Giang, W., Tian, F., Takahashi, Y. & Wang, H. G., 2025, In: Autophagy. 21, 5, p. 1059-1074 16 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice
Fundora, K. A., Zhuang, Y., Hamamoto, K., Wang, G., Chen, L., Hattori, T., Liang, X., Bao, L., Vangala, V., Tian, F., Takahashi, Y. & Wang, H. G., Apr 2025, In: Journal of Pharmacology and Experimental Therapeutics. 392, 4, 103524.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations
Prizes
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Career Citation Milestone Award - D (500) Club
Broach, J. (Recipient), Coates, M. (Recipient), Duffy, C. (Recipient), Gardner, A. (Recipient), Gill, D. (Recipient), Helm, K. (Recipient), Kimball, S. (Recipient), Leslie, D. (Recipient), Lipton, A. (Recipient), Ma, T. (Recipient), Naccarelli, G. (Recipient), Schmitz, K. (Recipient), Siedlecki, C. (Recipient), Stoute, J. (Recipient), Tombran-Tink, J. (Recipient) & Wang, H.-G. (Recipient), 2020
Prize
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Career Citation Milestone Award - D (500) Club
Barber, A. (Recipient), Belani, C. (Recipient), Bixler, E. (Recipient), Eslinger, P. (Recipient), Imamura, Y. (Recipient), Legro, R. (Recipient), Mailman, R. (Recipient), Schiff, S. (Recipient), Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2019
Prize
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Career Citation Milestone Award - D (500) Club
Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2017
Prize
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize