Projects per year
Personal profile
Research interests
Dr. Hong-Gang “H.G.” Wang formerly worked at the H. Lee Moffitt Cancer Center and the University of South Florida in Tampa, beginning as assistant professor in 1998 and advancing to the rank of professor before moving to Penn State College of Medicine in 2008. Research in Dr. Wang’s laboratory aims to better understand the fundamental mechanisms that control apoptosis (self-killing) and autophagy (self-eating) in the context of oncogenesis. In addition, targeting of these two closely related but distinct self-destructive cellular processes for anticancer drug discovery and development is another major interest of his research group. The ultimate goal of Dr. Wang’s research is to translate basic science discoveries to the development of new approaches for the treatment of cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Sanford Burnham Prebys Medical Discovery Institute
1993 → 1997
PhD, University of Tsukuba
1987 → 1992
BS, University of Tsukuba
1983 → 1987
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Non-canonical Caspase-8 Activation on Autophagosomal Membranes
Wang, H.-G. (PI)
8/1/18 → 1/31/26
Project: Research project
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Autophagosome closure by the ESCRT machinery
Wang, H.-G. (PI)
National Institute of General Medical Sciences
7/1/18 → 7/31/26
Project: Research project
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Autophagy Heterogeneity and Tumor Metastasis
Wang, H.-G. (PI)
4/1/21 → 3/31/23
Project: Research project
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Targeted Sphingolipid Metabolism for Treatment of AML
Amin, S. (CoPI), Cabot, M. C. (CoPI), Claxton, D. F. (CoPI), Fox, T. E. (CoPI), Kester, M. (CoPI), Liao, J. (CoPI), Loughran, T. P. (CoPI), Wang, H.-G. (CoPI), Horton, B. B. J. (CoPI), Chalfant, C. C. E. (CoPI), Conaway, M. (CoPI) & Janes, K. A. (CoPI)
9/10/13 → 5/31/25
Project: Research project
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Targeting Sphingosine Kinase in AML
Kester, M. (CoPI) & Wang, H.-G. (PI)
9/10/13 → 8/31/18
Project: Research project
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Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Bui, V., Liang, X., Ye, Y., Giang, W., Tian, F., Takahashi, Y. & Wang, H. G., 2025, In: Autophagy. 21, 5, p. 1059-1074 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice
Fundora, K. A., Zhuang, Y., Hamamoto, K., Wang, G., Chen, L., Hattori, T., Liang, X., Bao, L., Vangala, V., Tian, F., Takahashi, Y. & Wang, H. G., Apr 2025, In: Journal of Pharmacology and Experimental Therapeutics. 392, 4, 103524.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma
Kim, S. Y., Tang, M., Chih, S. Y., Sallavanti, J., Gao, Y., Qiu, Z., Wang, H. G. & Li, W., Dec 2025, In: Cell Death and Disease. 16, 1, 12.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Physiological insights into ESCRT-mediated phagophore closure: potential cytoprotective roles for ATG8ylated membranes
Hamamoto, K., Liang, X., Opozda, D. M., Wang, H. G. & Takahashi, Y., 2025, In: Autophagy. 21, 6, p. 1387-1389 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis
Wills, C. A., Liu, X., Chen, L., Zhao, Y., Liu, Z., Spiegelman, V. S., Sundstrom, J. & Wang, H. G., Jul 2024, In: Genes and Diseases. 11, 4, 101017.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Prizes
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Career Citation Milestone Award - D (500) Club
Broach, J. (Recipient), Coates, M. (Recipient), Duffy, C. (Recipient), Gardner, A. (Recipient), Gill, D. (Recipient), Helm, K. (Recipient), Kimball, S. (Recipient), Leslie, D. (Recipient), Lipton, A. (Recipient), Ma, T. (Recipient), Naccarelli, G. (Recipient), Schmitz, K. (Recipient), Siedlecki, C. (Recipient), Stoute, J. (Recipient), Tombran-Tink, J. (Recipient) & Wang, H.-G. (Recipient), 2020
Prize
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Career Citation Milestone Award - D (500) Club
Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2017
Prize
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Career Citation Milestone Award - D (500) Club
Barber, A. (Recipient), Belani, C. (Recipient), Bixler, E. (Recipient), Eslinger, P. (Recipient), Imamura, Y. (Recipient), Legro, R. (Recipient), Mailman, R. (Recipient), Schiff, S. (Recipient), Vgontzas, A. (Recipient) & Wang, H.-G. (Recipient), 2019
Prize
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Outstanding Collaborative Research Team
Adair, J. H. (Recipient), Amin, S. (Recipient), Claxton, D. (Recipient), Desai, D. (Recipient), Hengst, J. (Recipient), Liao, J. (Recipient), Paulson, R. (Recipient), Sharma, A. (Recipient), Stanley, B. (Recipient), Wang, H.-G. (Recipient), Yun, J. (Recipient) & Zhu, J. (Recipient), 2015
Prize