Personal profile
Research interests
Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.
Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.
Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.
Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.
She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
-
Targeting MK2 for Crohn's Disease
Pinchuk, I. (PI)
Congressionally Directed Medical Research Programs
5/1/22 → 3/31/26
Project: Research project
-
Regulatory role of CD90+ stromal cells in Th1/Th17 activity in Crohn's Disease
Pinchuk, I. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/14 → 6/30/19
Project: Research project
-
Protocol for establishing primary murine colonic fibroblast culture with induction of loxP/loxP deletion using transducible TAT-Cre recombinase
McAninch, C., Hahn, A., McAninch, S., Pinchuk, I. V. & Chulkina, M., Mar 20 2026, In: STAR Protocols. 7, 1, 104330.Research output: Contribution to journal › Article › peer-review
Open Access -
Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 responses in vitro and in vivo
de Matos Guedes, H. L., da Fonseca-Martins, A. M., Liang, Y., Carlsen, E. D., Henard, C. A., Pinchuk, I. V. & Soong, L., Dec 2025, In: Scientific reports. 15, 1, 37856.Research output: Contribution to journal › Article › peer-review
Open Access -
MK2 Inhibition in CD4+T Cells Protects Against IFNγand IL-17A, Chronic Inflammation, and Fibrosis in Inflammatory Bowel Disease Models
Howe, C. S., Chulkina, M., Syrcle, R., McAninch, C., McAninch, S., Pinchuk, I. V. & Beswick, E. J., Jun 1 2025, In: Inflammatory bowel diseases. 31, 6, p. 1664-1676 13 p.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
MR2938 relieves DSS-induced colitis in mice through inhibiting NF-κB signaling and improving epithelial barrier
Lv, L., Maimaitiming, M., Xia, S., Yang, J., Zhang, T., Wang, Y., Li, X., Pinchuk, I., Wang, P., Wang, C. Y. & Liu, Z., Nov 2025, In: Marine Life Science and Technology. 7, 4, p. 915-924 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut
Chulkina, M., Tran, H., Uribe, G., McAninch, S. B., McAninch, C., Seideneck, A., He, B., Lanza, M., Khanipov, K., Golovko, G., Powell, D. W., Davenport, E. R. & Pinchuk, I. V., May 27 2025, In: Cell Reports. 44, 5, 115553.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations