Projects per year
Personal profile
Research interests
Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Post-doctoral training, Laboratory of Molecular Carcinogenesis and Laboratory of Metabolism, National Cancer Institute
1995 → 1999
Post-doctoral training, University of California at Davis
1992 → 1995
External positions
Fellow, Academy of Toxicological Sciences
Jan 1 2012 → …
Fellow, Academy of Toxicological Sciences
2012 → …
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Collaborations and top research areas from the last five years
Projects
- 7 Finished
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Unique targeting of PPARβ/δ regulation for cancer prevention and therapy
Peters, J. M. (PI), Patterson, A. D. (CoPI) & Peters, J. J. M. (CoPI)
12/6/19 → 11/30/23
Project: Research project
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Modulation of liver cancer by PPARbeta/delta
Peters, J. M. (PI)
6/4/10 → 4/30/16
Project: Research project
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Transcriptional regulation of polycyclic aromatic hydrocarbon metabolism
Peters, J. M. (PI)
1/1/10 → 11/30/14
Project: Research project
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Modulation of AhR-dependent signaling by PPARb/d
Peters, J. M. (PI)
7/17/09 → 6/30/10
Project: Research project
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2022-2023 Toxicological Sciences: Paper of the Year
Will, Y. & Peters, J. M., Mar 1 2024, In: Toxicological Sciences. 198, 1, p. 2-3 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.Research output: Contribution to journal › Article › peer-review
Open Access -
Chlorpyrifos modulates the mouse gut microbiota and metabolic activity
Nichols, R. G., Rimal, B., Hao, F., Peters, J. M., Davenport, E. R. & Patterson, A. D., Oct 2024, In: Environment international. 192, 109022.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation
Yokoyama, S., Koo, I., Aibara, D., Tian, Y., Murray, I. A., Collins, S. L., Coslo, D. M., Kono, M., Peters, J. M., Proia, R. L., Gonzalez, F. J., Perdew, G. H. & Patterson, A. D., Oct 28 2024, In: Advanced Science. 11, 40, 2400794.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Thank You, ToxSci 2024 Reviewers
Peters, J. M., Dec 1 2024, In: Toxicological Sciences. 202, 2, p. 153-156 4 p.Research output: Contribution to journal › Editorial › peer-review
Open Access
Activities
- 3 Oral presentation
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Unraveling the controversial role of peroxisome proliferator-activated receptor-β/δ in cancer
Peters, J. M. (Keynote speaker)
2016 → …Activity: Talk types › Oral presentation
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Peroxisome proliferator-activated receptors as molecular targets for the treatment and prevention of diseases
Peters, J. M. (Invited speaker)
2009 → …Activity: Talk types › Oral presentation
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PPARβ(δ)-dependent regulation of cell proliferation, differentiation and carcinogenesis: Studies from null mouse models
Peters, J. M. (Invited speaker)
2005 → …Activity: Talk types › Oral presentation