Calculated based on number of publications stored in Pure and citations from Scopus
20022023

Research activity per year

Personal profile

Research interests

Dr. Jeffrey Neighbors’ lab is focused on drug development. One current research project is centered on the development of novel agents which inhibit steps in the mevalonate (cholesterol synthesis) pathway to reduce transcription of genes targeted by the Hippo pathway transcription factor TAZ as potential treatments for osteosarcoma.

Additionally, the lab is studying the potential for statin drugs that inhibit this same pathway as treatment for neuroblastoma and other cancers.

A completely different project looks at a family of natural products, pawhuskins, isolated from a prairie plant, that have antagonist activity at several opioid receptors and are under investigation for the potential to increase wound healing by inhibiting opioid growth factor activity.

Before coming to Penn State, Dr. Neighbors worked for a small biotech company driving the drug development efforts and has experience integrating development activity across disciplines from chemical synthesis to pharmacokinetics and ADME/DMPK studies.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Collaborations and top research areas from the last five years

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