Projects per year
Personal profile
Research interests
The overall goals of Dr. Karam El-Bayoumy’s research are to understand the mechanisms at the cellular and molecular levels that can account for cancer induction and develop biomarkers for early detection. For more than 30 years, his laboratory has been funded from NCI, NIEHS, NIDCR, DOD and The Komen Foundation, and he has more than 240 peer-reviewed publications.
Dr. El-Bayoumy’s research is focused on the prevention of tobacco and environmentally-related cancers by various synthetic and naturally-occurring chemopreventive agents, combined with dietary manipulation initially in preclinical model systems, then translates the findings into clinical cancer prevention initiatives. He discovered novel chemopreventive selenium compounds against the development of several cancers in preclinical animal models and showed for the first time that selenized yeast reduced oxidative stress in healthy men.
His team demonstrated, using a novel animal model developed in his lab, that black raspberry (BRB) inhibited DNA damage, mutagenesis and oral squamous cell carcinoma (OSCC) induced by the tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) in the mouse oral cavity; he also reported that BRB enhanced DNA repair of bulky lesions induced by chemical DB[a,l]P and physical (UV) carcinogens. His team also showed that hypomethylated Fgf3 (a gene frequently amplified in OSCC and is involved in epithelial mesenchymal transition) is a potential biomarker for early detection of OSCC; this gene was altered by BRB in a manner consistent with its chemopreventive action.
Dr. El-Bayoumy focuses on developing highly effective chemopreventive agents against tobacco smoke inducing lung cancer and developing biomarkers for early detection in noninvasive fluids indicative of cigarette smoking using various proteomic approaches.
During the last decade, he has been focusing on understanding the mechanistic role of Omega-3 fatty acids in breast cancer prevention in preclinical and clinical studies as well as developing novel liposomal formulation as an effective strategy to deliver select chemopreventive agents.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 7 Finished
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Metabolic activation of nitroarenes and Nrf2-Keap1
Penning, T. T. M. (PI) & El-Bayoumy, K. (CoPI)
National Institute of Environmental Health Sciences
5/8/19 → 4/30/24
Project: Research project
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CORE--BIOSTATISTICS, HISTOPATHOLOGY, MOLECULAR ANALYSIS AND SYNTHESIS
El-Bayoumy, K. (PI)
10/1/98 → 9/30/99
Project: Research project
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CHEMOPREVENTION OF MAMMARY CANCER BY ORGANOSELENIUM
El-Bayoumy, K. (PI)
10/1/97 → 9/30/98
Project: Research project
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Tobacco Carcinogenesis and Chemoprevention
Fiala, E. S. (CoPI), El-Bayoumy, K. (CoPI), Melikian, A. A. (CoPI), Prokopczyk, B. (CoPI) & El-bayoumy, K. E. (PI)
6/17/96 → 2/28/09
Project: Research project
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CHEMOPREVENTION OF LUNG CANCER BY ORGANOSELENIUM--MODEL STUDIES
El-Bayoumy, K. (PI)
10/1/95 → 9/30/99
Project: Research project
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Black Raspberry Modulates Cecal and Oral Microbiomes at the Early Stage of a Dibenzo[def,p]chrysene-Induced Murine Oral Cancer Model
Zhao, J., Sun, Y. W., Chen, K. M., Aliaga, C., Bisanz, J. E. & El-Bayoumy, K., Jan 1 2025, In: Cancer Prevention Research. 18, 1, p. 11-21 11 p.Research output: Contribution to journal › Article › peer-review
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Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Chan, K., Tseng, C., Milarachi, E., Goldrich, D., Schneper, L., Sheldon, K., Aliaga, C., Alam, S., Chatterjee, S., El-Bayoumy, K., Meyers, C., Goldenberg, D. & Broach, J. R., Feb 1 2025, In: Molecular Cancer Research. 23, 2, p. 119-127 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Inhibition of benzo[a]pyrene-induced DNA adduct in buccal cells of smokers by black raspberry lozenges
Chen, K. M., Krebs, N. M., Sun, Y. W., Sun, D., Liao, J., Reinhart, L., Krzeminski, J., Amin, S., Stoner, G., Mallery, S. R. & El-Bayoumy, K., Jan 1 2025, In: Carcinogenesis. 46, 1, bgae067.Research output: Contribution to journal › Article › peer-review
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Metabolic reprogramming in saliva of mice treated with the environmental and tobacco carcinogen dibenzo[def, p]chrysene
Sun, Y. W., Chen, K. M., Aliaga, C. & El-Bayoumy, K., Dec 2024, In: Scientific reports. 14, 1, 29517.Research output: Contribution to journal › Article › peer-review
Open Access -
The Effects of Black Raspberry as a Whole Food–Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers
Chen, K. M., Sun, Y. W., Krebs, N. M., Reinhart, L., Sun, D., Liao, J., Cook, R., Bond, P. E., Mallery, S. R. & El-Bayoumy, K., Apr 1 2024, In: Cancer Prevention Research. 17, 4, p. 157-167 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Prizes
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Outstanding Collaborative Research Team
El-Bayoumy, K. (Recipient), Manni, A. (Recipient), Richie, J. (Recipient), Liao, J. (Recipient), Vanden Heuvel, J. P. (Recipient), Demers, L. (Recipient), Dillard, J. (Recipient) & Rogers, C. J. (Recipient), 2016
Prize