Projects per year
Personal profile
Research interests
The overall goals of Dr. Karam El-Bayoumy’s research are to understand the mechanisms at the cellular and molecular levels that can account for cancer induction and develop biomarkers for early detection. For more than 30 years, his laboratory has been funded from NCI, NIEHS, NIDCR, DOD and The Komen Foundation, and he has more than 240 peer-reviewed publications.
Dr. El-Bayoumy’s research is focused on the prevention of tobacco and environmentally-related cancers by various synthetic and naturally-occurring chemopreventive agents, combined with dietary manipulation initially in preclinical model systems, then translates the findings into clinical cancer prevention initiatives. He discovered novel chemopreventive selenium compounds against the development of several cancers in preclinical animal models and showed for the first time that selenized yeast reduced oxidative stress in healthy men.
His team demonstrated, using a novel animal model developed in his lab, that black raspberry (BRB) inhibited DNA damage, mutagenesis and oral squamous cell carcinoma (OSCC) induced by the tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) in the mouse oral cavity; he also reported that BRB enhanced DNA repair of bulky lesions induced by chemical DB[a,l]P and physical (UV) carcinogens. His team also showed that hypomethylated Fgf3 (a gene frequently amplified in OSCC and is involved in epithelial mesenchymal transition) is a potential biomarker for early detection of OSCC; this gene was altered by BRB in a manner consistent with its chemopreventive action.
Dr. El-Bayoumy focuses on developing highly effective chemopreventive agents against tobacco smoke inducing lung cancer and developing biomarkers for early detection in noninvasive fluids indicative of cigarette smoking using various proteomic approaches.
During the last decade, he has been focusing on understanding the mechanistic role of Omega-3 fatty acids in breast cancer prevention in preclinical and clinical studies as well as developing novel liposomal formulation as an effective strategy to deliver select chemopreventive agents.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Metabolic activation of nitroarenes and Nrf2-Keap1
Penning, T. T. M. & El-Bayoumy, K.
National Institute of Environmental Health Sciences
5/8/19 → 4/30/24
Project: Research project
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TOBACCO USE AND ORAL CANCER: ETIOLOGY AND PREVENTION
Richie, J., El-Bayoumy, K., Hoffman, D. K. & Hoffmann, D. K.
9/30/99 → 8/31/03
Project: Research project
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CORE--BIOSTATISTICS, HISTOPATHOLOGY, MOLECULAR ANALYSIS AND SYNTHESIS
10/1/98 → 9/30/99
Project: Research project
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CHEMOPREVENTION OF CANCER BY ORGANOSELENIUM
Reddy, B. S., El-Bayoumy, K. & Fiala, E. S.
8/1/98 → 7/31/02
Project: Research project
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Lifestyle Modifications and Breast Cancer Risk
Manni, A. & El-Bayoumy, K., Jun 2023, In: Cancers. 15, 11, 2870.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Animal studies of tobacco and cancer
El-Bayoumy, K., Jan 17 2022, Tobacco And Cancer: The Science And The Story. World Scientific Publishing Co. Pte Ltd, p. 75-100 26 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells
Chen, K. M., Sun, Y. W., Sun, D., Gowda, K., Amin, S. & El-Bayoumy, K., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2152-2159 8 p.Research output: Contribution to journal › Article › peer-review
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Building a foundation for precision onco-nutrition: Docosahexaenoic acid and breast cancer
Thompson, H. J., Neil, E. S., McGinley, J. N., Fitzgerald, V. K., El Bayoumy, K. & Manni, A., Jan 1 2022, In: Cancers. 14, 1, 157.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells
Chen, K. M., Sun, Y. W., Krebs, N. M., Sun, D., Krzeminski, J., Reinhart, L., Gowda, K., Amin, S., Mallery, S., Richie, J. P. & El-Bayoumy, K., Aug 1 2022, In: Carcinogenesis. 43, 8, p. 746-753 8 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Prizes
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Outstanding Collaborative Research Team
El-Bayoumy, Karam (Recipient), Manni, Andrea (Recipient), Richie, John (Recipient), Liao, Jiangang "Jason" (Recipient), Vanden Heuvel, John Patrick (Recipient), Demers, Laurence (Recipient), Dillard, James (Recipient) & Rogers, Connie Jo (Recipient), 2016
Prize