Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Mark Hedglin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Deciphering the progression and regulation of human translesion DNA synthesis
Hedglin, M. (PI)
National Institute of General Medical Sciences
8/1/22 → 5/31/25
Project: Research project
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Polymerase Switching During Translesion DNA Synthesis within the Human System
Hedglin, M. (PI)
9/1/12 → 8/31/15
Project: Research project
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Direct, ensemble FRET approaches to monitor transient state kinetics of human DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis
Norris, J. L. & Hedglin, M., Jan 2024, Chemical and Genomic Methods in Nucleic Acid Biology. Eichman, B. F. (ed.). Academic Press Inc., p. 271-309 39 p. (Methods in Enzymology; vol. 705).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress
Muoio, D., Laspata, N., Dannenberg, R. L., Curry, C., Darkoa-Larbi, S., Hedglin, M., Uttam, S. & Fouquerel, E., Dec 2024, In: Nature communications. 15, 1, 2857.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels
Pytko, K. G., Dannenberg, R. L., Eckert, K. A. & Hedglin, M., Apr 16 2024, In: Biochemistry. 63, 8, p. 969-983 15 p.Research output: Contribution to journal › Article › peer-review
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Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis
Norris, J. L., Rogers, L. O., Pytko, K. G., Dannenberg, R. L., Perreault, S., Kaushik, V., Kuppa, S., Antony, E. & Hedglin, M., Jul 22 2024, In: Nucleic acids research. 52, 13, p. 7650-7664 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics
Hoitsma, N. M., Norris, J., Khoang, T. H., Kaushik, V., Chadda, R., Antony, E., Hedglin, M. & Freudenthal, B. D., Jul 21 2023, In: Nucleic acids research. 51, 13, p. 6738-6753 16 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations