Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Mark Hedglin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Deciphering the progression and regulation of human translesion DNA synthesis
Hedglin, M. (PI)
National Institute of General Medical Sciences
8/1/22 → 5/31/26
Project: Research project
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Polymerase Switching During Translesion DNA Synthesis within the Human System
Hedglin, M. (PI)
9/1/12 → 8/31/15
Project: Research project
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PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways
Norris, J. L., Rogers, L. O., Young, G., Pytko, K. G., Dannenberg, R. L., Perreault, S., Kaushik, V., Antony, E. & Hedglin, M., Jan 13 2026, In: Nucleic acids research. 54, 1, gkaf1478.Research output: Contribution to journal › Article › peer-review
Open Access -
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
Sanford, S. L., Badstübner, M., Gerber, M., Mannherz, W., Lampl, N., Dannenberg, R., Hinchie, A., Schaich, M. A., Myong, S., Hedglin, M., Agarwal, S., Alder, J. K., Stone, M. D. & Opresko, P. L., Dec 2026, In: Nature communications. 17, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities
Dannenberg, R. L., Cardina, J. A., Washington, H., Gao, S., Greenberg, M. M. & Hedglin, M., Jul 22 2025, In: Nucleic acids research. 53, 13, gkaf646.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA
Shin, Y., Hedglin, M. & Murakami, K. S., Apr 2025, In: Journal of Biological Chemistry. 301, 4, 108342.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome
Hile, S. E., Weissensteiner, M. H., Pytko, K. G., Dahl, J., Kejnovsky, E., Kejnovská, I., Hedglin, M., Georgakopoulos-Soares, I., Makova, K. D. & Eckert, K. A., May 8 2025, In: Nucleic acids research. 53, 8, gkaf352.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations