Projects per year
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Mark Hedglin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Deciphering the progression and regulation of human translesion DNA synthesis
Hedglin, M. (PI)
National Institute of General Medical Sciences
8/1/22 → 5/31/26
Project: Research project
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Polymerase Switching During Translesion DNA Synthesis within the Human System
Hedglin, M. (PI)
9/1/12 → 8/31/15
Project: Research project
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A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities
Dannenberg, R. L., Cardina, J. A., Washington, H., Gao, S., Greenberg, M. M. & Hedglin, M., Jul 22 2025, In: Nucleic acids research. 53, 13, gkaf646.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA
Shin, Y., Hedglin, M. & Murakami, K. S., Apr 2025, In: Journal of Biological Chemistry. 301, 4, 108342.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome
Hile, S. E., Weissensteiner, M. H., Pytko, K. G., Dahl, J., Kejnovsky, E., Kejnovská, I., Hedglin, M., Georgakopoulos-Soares, I., Makova, K. D. & Eckert, K. A., May 8 2025, In: Nucleic acids research. 53, 8, gkaf352.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Direct, ensemble FRET approaches to monitor transient state kinetics of human DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis
Norris, J. L. & Hedglin, M., Jan 2024, Chemical and Genomic Methods in Nucleic Acid Biology. Eichman, B. F. (ed.). Academic Press Inc., p. 271-309 39 p. (Methods in Enzymology; vol. 705).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress
Muoio, D., Laspata, N., Dannenberg, R. L., Curry, C., Darkoa-Larbi, S., Hedglin, M., Uttam, S. & Fouquerel, E., Dec 2024, In: Nature communications. 15, 1, 2857.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations