Projects per year
Personal profile
Research interests
The Swulius lab uses a multi-scale imaging approach combined with computer vision to explore the the structural complexity of whole neuronal cells in different stages of development and under stress-induced degeneration. They have 20 years of cryo-electron microscopy and fluorescence microscopy experience, and use this expertise to better understand fundamental mechanisms of neuronal cell biology. They have invested heavily in developing methods for parsing large imaging datasets using deep learning, and push the boundaries of what this machine learning approach is capable of.
The Swulius lab is always interested in meeting students who are curious about their research and the opportunities that exist within the lab.
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Compromised two-start zigzag chromatin folding in immature mouse retina cells driven by irregularly spaced nucleosomes with short DNA linkers
Kable, B., Portillo-Ledesma, S., Popova, E. Y., Jentink, N., Swulius, M., Li, Z., Schlick, T. & Grigoryev, S. A., Jun 10 2025, In: Nucleic acids research. 53, 10, gkaf457.Research output: Contribution to journal › Article › peer-review
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From Fully Stretched to Collapsed Chains: Bottlebrush Polymer Grafted Particles
Sevening, J. N., Nupnar, N., Adhikary, S., Reifsnyder Hickey, D., Swulius, M. T., Koerner, H., Hore, M. J. A. & Hickey, R. J., Oct 22 2024, In: Macromolecules. 57, 20, p. 9616-9626 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Training Robust Deep Learning Models with Synthetic Cryo-ET Data
Swulius, M., Jul 24 2024, In: Microscopy and Microanalysis. 30, 2024, p. 721 1 p.Research output: Contribution to journal › Conference article › peer-review
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Cryoelectron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination
Jentink, N., Purnell, C., Kable, B., Swulius, M. T. & Grigoryev, S. A., Sep 21 2023, In: Molecular cell. 83, 18, p. 3236-3252.e7Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Extracellular vesicles from retinal pigment epithelial cells expressing R345W-Fibulin-3 induce epithelial-mesenchymal transition in recipient cells
Zhou, M., Zhao, Y., Weber, S. R., Gates, C., Carruthers, N. J., Chen, H., Liu, X., Wang, H. G., Ford, M., Swulius, M. T., Barber, A. J., Grillo, S. L. & Sundstrom, J. M., Oct 2023, In: Journal of Extracellular Vesicles. 12, 10, 12373.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations