Projects per year
Personal profile
Research interests
Dr. Patricia McLaughlin’s research focuses on the Opioid Growth Factor (OGF) – OGF receptor (OGFr) pathway and mechanisms of action in homeostasis and disease. Early collaborative work with Dr. Ian Zagon resulted in the identification of [Met5]-enkephalin as the endogenous ligand for the OGF-OGFr pathway. Subsequently, a new nuclear-associated receptor was identified and termed OGFr. One group in the laboratory has characterized and cloned the OGFr gene in human, mouse and rat. Protein chemistry studies, along with structural biology, determined that the OGFr is a uniquely unstructured nuclear receptor. The mechanism of action was determined to involve inhibition of DNA synthesis with the specific mechanistic pathway involving upregulation of cyclin-dependent inhibitory kinases p16 and p21. OGF action is receptor-mediated, reversible, and not associated with apoptosis/necrosis. OGF is tissue non-specific and has been identified in proliferating cells and tissues derived from all 3 dermal layers.
Currently, the lab’s work is translational, focusing on disease-based pathways that are characterized by a perturbation in the OGF-OGFr axis. Consequences of receptor blockade of the OGF-OGFr axis are being studied with an emphasis on the etiology and treatment of complications (e.g., delayed wound healing, dry eye, impaired bone composition) arising from long-term diabetes (Type 1 or Type 2). These investigations (humans and animal models) focus on treatment options and utilize confocal microscopy, animal surgery, immunohistochemistry and tissue culture.
In another series of studies, the lab is testing the hypothesis that down-regulation of the inhibitory OGF peptide plays a role in multiple sclerosis and other autoimmune diseases. The lab is also currently validating serum biomarkers and cytokine expression profiles that correspond to changes in behavior and MRI imaging that may be related to disease progression and response to therapy. The clinical and animal research is both qualitative and quantitative in design and is supported by NIH, ADA, TSF (PA) and foundations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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ENDOGENOUS OPIOID SYSTEMS AND HEART DEVELOPMENT
McLaughlin, P. (PI)
National Heart, Lung, and Blood Institute
1/1/94 → 12/31/00
Project: Research project
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Topical naltrexone increases aquaporin 5 production in the lacrimal gland and restores tear production in diabetic rats
Diaz, D., Sassani, J. P., Zagon, I. S. & McLaughlin, P. J., 2024, In: Experimental Biology and Medicine. 249, 10175.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice
Kumari, R., Kareem, Z. Y. & McLaughlin, P. J., Sep 2023, In: Neurochemical Research. 48, 9, p. 2835-2846 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Addiction III: From mouse to man
McLaughlin, P. J., West, E. A., Grigson, P. S. & Hobkirk, A. L., Feb 2023, In: Brain Research Bulletin. 193, p. 22-26 5 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain
Kareem, Z. Y., McLaughlin, P. J. & Kumari, R., Jun 2023, In: Neuropeptides. 99, 102325.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini-pigs
McLaughlin, P. J., Sassani, J. W. & Zagon, I. S., Sep 2023, In: Drug Development Research. 84, 6, p. 1279-1284 6 p.Research output: Contribution to journal › Article › peer-review
Prizes
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Dean's Award for Excellence in Teaching
McAlevy, M. (Recipient), Bonavia, A. (Recipient), Malhotra, A. (Recipient), Weller, G. E. (Recipient), Waning, D. (Recipient), Lanza, M. (Recipient), Ken, K. (Recipient), McCarver, S. (Recipient), Glasser, J. (Recipient), Schooler, J. (Recipient), Lewis, S. (Recipient), Onks, C. (Recipient), Rao, R. (Recipient), Nickolich, S. (Recipient), Helm, L. (Recipient), Critchfield, L. (Recipient), Myers, K. (Recipient), Green, M. (Recipient), Songdej, N. (Recipient), Narayana, S. (Recipient), Razjouyan, H. (Recipient), Duca, N. (Recipient), Casas, R. (Recipient), Cooper, J. (Recipient), Wright, R. (Recipient), Karasinski, A. (Recipient), Probolus, J. A. (Recipient), Madara, J. (Recipient), Guck, D. (Recipient), Ingram, D. (Recipient), De Obaldia, A. (Recipient), Hussein, R. (Recipient), McGillen, B. (Recipient), Chapman, T. (Recipient), Munyon, R. (Recipient), Kinard, S. R. (Recipient), Banks, S. (Recipient), Genao, I. (Recipient), McShane, M. (Recipient), Allie, S. R. (Recipient), Silberman, Y. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Grogan, J. (Recipient), Nguyen, J. (Recipient), Donato, H. (Recipient), Fox, E. (Recipient), Gniady, J. (Recipient), Oladipo, O. (Recipient), Abendroth, C. (Recipient), Keefer, L. (Recipient), Massare, B. (Recipient), Undar, A. (Recipient), Mondal, P. (Recipient), Mainali, G. (Recipient), Jhaveri, P. (Recipient), Freiberg, A. (Recipient), Levenson, R. (Recipient), Mailman, R. (Recipient), Boodoo, R. (Recipient), Francis, A. (Recipient), Hameed, U. (Recipient), Yadav, S. (Recipient), Calo, W. (Recipient), Pinto, C. (Recipient), Cooper, A. (Recipient), Kulaylat, A. (Recipient), Scow, J. (Recipient), Roberts, J. (Recipient), Winder, J. (Recipient), Aminsharifi, A. (Recipient), Adams, N. (Recipient) & van Riggelen, J. (Recipient), 2023
Prize
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Dean's Award for Excellence in Teaching
Hussein, R. (Recipient), Stredny, E. (Recipient), Whitley, M. (Recipient), Mnatsakanyan, N. (Recipient), Raimundo, N. (Recipient), Zarnescu, D. (Recipient), Adams, N. (Recipient), Lanza, M. (Recipient), Kowalczyk, A. (Recipient), Travelute, C. (Recipient), Marco, C. (Recipient), Tondt, J. (Recipient), Anderson, A. (Recipient), Heron, C. (Recipient), Newman, R. (Recipient), Richard, D. (Recipient), Scartozzi, C. (Recipient), Dellasega, C. (Recipient), Akhtar, N. (Recipient), Albano-Aluquin, S. (Recipient), Chisty, A. (Recipient), Crook, T. (Recipient), Federici, E. H. (Recipient), Ingram, D. (Recipient), Lakshmanan, P. (Recipient), Mathew, A. (Recipient), Narayana, S. (Recipient), Prokop, A. (Recipient), Razjouyan, H. (Recipient), Tariq, A. (Recipient), Thompson, B. (Recipient), Thompson, E. (Recipient), Trivedi, N. (Recipient), Van Scoy, L. (Recipient), Wong, J. (Recipient), Allie, S. R. (Recipient), Browning, K. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Mamarabadi, M. (Recipient), Shankar, L. (Recipient), Bowie, E. (Recipient), Petfield, J. (Recipient), Whitaker, M. (Recipient), Aynardi, J. (Recipient), Allen, N. (Recipient), Cunningham, B. (Recipient), Gandhi, C. (Recipient), Jairath, B. (Recipient), Lutzkanin, K. M. (Recipient), Kerris, E. (Recipient), Nelson, A. (Recipient), Shook, J. (Recipient), Proctor, E. A. (Recipient), Raup-Konsavage, W. (Recipient), Romanoski, N. (Recipient), Graziane, J. (Recipient), Llorente, A. (Recipient), Nutting, S. (Recipient), Pinto, C. (Recipient), Yingst, J. (Recipient), Zhou, S. (Recipient), Mahase, S. (Recipient), Brian, P. (Recipient), Goldman, E. (Recipient), Maffie, J. (Recipient), Brahmbhatt, R. (Recipient), Fahy, A. (Recipient), Gish, J. (Recipient), Reed, M. F. (Recipient) & Tomasko, J. (Recipient), 2024
Prize
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Dean's Award for Excellence in Teaching
Aprile, B. (Recipient), Aumiller, B. B. (Recipient), Berkey, F. (Recipient), Bonavia, A. (Recipient), Booth, J. (Recipient), Brennan, K. (Recipient), Browning, K. (Recipient), Buchkovich, N. (Recipient), Butt, F. K. (Recipient), Carrel, L. (Recipient), Choe, A. (Recipient), Clarke, S. (Recipient), Coleman, M. (Recipient), Dalke, K. (Recipient), Devaraj, T. (Recipient), Duryea, S. (Recipient), Enama, J. (Recipient), Evey, L. (Recipient), Finch, E. (Recipient), Fischer, M. (Recipient), Gallo, R. (Recipient), Gavigan, P. (Recipient), Ghaffari, G. (Recipient), Go, P. (Recipient), Grana, J. (Recipient), Greensmith, J. (Recipient), Grogan, J. (Recipient), Hajnal, A. (Recipient), Helm, M. (Recipient), Hempel, N. (Recipient), Imamura, F. (Recipient), Jain, R. (Recipient), Jeganathan, N. (Recipient), Kelle, A. (Recipient), Kumar, A. (Recipient), Kwun, H. J. (Recipient), Lang, C. (Recipient), Lutzkanin, A. (Recipient), Martin, K. (Recipient), McGarrity, T. (Recipient), McHale, K. (Recipient), McLaughlin, P. (Recipient), Mormando, C. (Recipient), Nguyen, J. (Recipient), Nickolich, M. (Recipient), Ouyang, T. (Recipient), Pachuski, J. (Recipient), Polimera, H. (Recipient), Potochny, E. (Recipient), Rakszawski, K. L. (Recipient), Reyes, L. (Recipient), Sankoorikal, B.-J. (Recipient), Shantz, L. (Recipient), Singh, M. (Recipient), Songdej, N. (Recipient), Spotts, R. (Recipient), Swigart, A. (Recipient), Varner, M. (Recipient), Verma, N. (Recipient), Walter, V. (Recipient), Wang, C.-Y. (Recipient), Warfield, D. (Recipient), Wilson, M. N. (Recipient) & Hussein, R. (Recipient), 2021
Prize
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Dean’s Award for Excellence in Teaching
Hollins, L. C. (Recipient), Nisnevitch-Savarese, Z. (Recipient), Read, S. (Recipient), Rossi, J. (Recipient), Royo, M. (Recipient), Sarraf, E. (Recipient), Shah, B. (Recipient), Moldovan, G.-L. (Recipient), van Riggelen, J. (Recipient), Shantz, L. (Recipient), Yengo, C. (Recipient), Booth, J. (Recipient), Bates, E. (Recipient), Schuster, A. (Recipient), Clebak, K. (Recipient), Daniels, E. W. (Recipient), Hays, A. (Recipient), Hemerly, N. (Recipient), Thompson, A. (Recipient), George, D. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Acharya, J. (Recipient), De Jesus, S. (Recipient), O'Leary, A. (Recipient), Wright, T. (Recipient), Cantore, W. (Recipient), Pantanelli, S. (Recipient), Millard, R. (Recipient), Updegrove, G. F. (Recipient), Choi, K. (Recipient), Darowish, C. (Recipient), Dooley, A. (Recipient), Hackman, N. (Recipient), Krawiec, C. (Recipient), Oji-Mmuo, C. (Recipient), Ryan, S. (Recipient), Shedlock, A. (Recipient), Tunks, R. (Recipient), Critchfield, L. (Recipient), Bellon, A. (Recipient), Dougherty, K. (Recipient), Lagman, J. (Recipient), Mahgoub, Y. (Recipient), Dreibelbis, T. (Recipient), Richie, J. (Recipient), Wang, L. (Recipient), Methratta, S. (Recipient), Chauvin, N. (Recipient), Deutsch, M. (Recipient), Kulaylat, A. (Recipient), Paulishak, M. (Recipient), Staszak, R. (Recipient) & MacDonald, S. (Recipient), 2022
Prize