Raymond Reichwein

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Raymond Reichwein, MD

    Calculated based on number of publications stored in Pure and citations from Scopus
    1998 …2025

    Research activity per year

    Personal profile

    Professional information

    NIH Stroke Scale certification, American Heart Association, 2020

    CITI course biosafety certification, CITI Collaborative Institutional Training Initiative, 2019

    Modified Rankin scale certification, American Heart Association, 2019

    Board-certified in neurology, American Board of Psychiatry and Neurology, 2002 (recertified 2013)

    Research interests

    Dr. Raymond Weichwein's research interests include telehealth; primary and secondary stroke prevention; acute stroke management, particularly acute ischemic stroke treatment and hospital care; transient ischemic attack (TIA) evaluation and management; stroke recovery; and other areas of stroke care.

    In telehealth, his work focuses on the optimal use of virtual telehealth across the continuum of stroke care - acute stroke care (to include prehospital/EMS care), inpatient care, outpatient care and stroke rehabilitation.

    In the area of primary and secondary stroke prevention, Dr. Reichwein is conducting an ongoing primary care provider (PCP)-focused project, first identifying high-risk patients (based on documented risk factors and CHADS-VASC score) in advance of an upcoming patient visit to the PCP, then formulating a one-year plan to address these risk factors and provide optimal TIA/stroke education (develop a population-based health care network model).

    In acute stroke management, particularly acute ischemic stroke treatment and hospital care, Dr. Reichwein has interest in optimizing stroke systems of care/networks, starting with pre-hospital EMS evaluation, then emergency department evaluation, intravenous thrombolytic therapy (tPA and tenecteplase), endovascular thrombectomy, critical care/hospitalization stroke management and post-discharge follow-up care. Dr. Reichwein is also interested in the use of advanced diagnostic testing, specifically CT (brain) perfusion and multiple-phase CT angiography, to optimally select patients for acute ischemic stroke treatments, and in optimal treatment of post-stroke cerebral edema.

    In the area of transient ischemic attack (TIA) evaluation and management, Dr. Reichwein has an interest in urgent clinical evaluation, diagnostic testing and treatment interventions for suspected TIA patients.

    Regarding stroke recovery, Dr. Reichwein is the principal investigator in the MASTERS-2 research trial evaluating intravenous stem cell therapy vs. placebo within 18 to 36 hours of acute ischemic stroke symptom onset. He also is beginning an investigator-initiated project on optimal medication management (dopaminergic vs. SSRI vs. other stimulant treatment) for post-stroke depression and fatigue. Dr. Reichwein also has interest in neuro-modulation, to include transcranial magnetic stimulation treatment, to optimize stroke recovery.

    Finally, Dr. Reichwin is the principal investigator in the NIH-sponsored Sleep Smart research trial via StrokeNet, aimed at identifying significant obstructive sleep apnea within 14 days of TIA or stroke, then pursuing acute sleep apnea treatment with CPAP therapy (vs. no treatment) to determine if this leads to decreased subsequent recurrent TIA/stroke/vascular events and/or improves subsequent clinical outcome in stroke patients.

    Clinical interests

    Dr. Raymond Reichwein has clinical interests in telehealth; primary and secondary stroke prevention; acute stroke management, particularly acute ischemic stroke treatment and hospital care; transient ischemic attack (TIA) evaluation and management; stroke recovery; and other areas of stroke care.

    In telehealth, Dr. Reichwein's practice focuses on the optimal use of virtual telehealth across the continuum of stroke care - acute stroke care (to include prehospital/EMS care), inpatient care, outpatient care and stroke rehabilitation.

    In the area of primary and secondary stroke prevention, Dr. Reichwein focuses on multiple common risk factors and optimal medication, plus behavioral/dietary management.

    Regarding his interest in optimal atrial fibrillation identification and optimal future stroke prevention, Dr. Reichwein has interest in silent significant microvascular cerebrovascular disease and pursuit of optimal secondary stroke prevention measures. In this area, he seeks to develop a population-based health care/network stroke prevention model.

    In the area of acute stroke management, particularly acute ischemic stroke treatment and hospital care, Dr. Reichwein is interested in optimizing stroke systems of care/networks, starting with pre-hospital EMS evaluation, then emergency department evaluation, intravenous thrombolytic therapies (tPA and tenecteplase), endovascular thrombectomy, critical care/hospitalization stroke management and post-discharge follow-up care. He also uses advanced diagnostic testing, specifically CT (brain) perfusion and multiple-phase CT angiography, to optimally select patients for acute ischemic stroke treatments. He is interested in the optimal treatment of post-stroke cerebral edema.

    Regarding transient ischemic attack (TIA) evaluation and management, Dr. Reichwein is interested in urgent clinical evaluation, diagnostic testing and treatment interventions for suspected TIA patients.

    In the area of stroke recovery, he has interest in stem cell therapy (various routes) for post-stroke recovery. He also has interest in optimal medication management (dopaminergic vs. SSRI vs. other stimulant treatment) for post-stroke depression and fatigue, and is pursuing neuro-modulation, to include transcranial magnetic stimulation treatment.

    Finally, Dr. Reichwein has clinical interest in early identification of significant obstructive sleep apnea and subsequent optimal treatment to prevent recurrent ischemic events/stroke as well as decrease progression of microvascular cerebrovascular disease.

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    Clinical Neurophysiology, Fellowship, Penn State Health Milton S. Hershey Medical Center

    1996 → 1997

    Neurology, Residency, Penn State Health Milton S. Hershey Medical Center

    1993 → 1996

    Internal Medicine, Residency, Penn State Health Milton S. Hershey Medical Center

    1991 → 1993

    MD, Penn State College of Medicine

    1987 → 1991

    Premedicine, BS, The Pennsylvania State University

    1983 → 1987

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    • Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial

      Anderson, C. S., Summers, D., Ouyang, M., Sui, Y., Johnson, B., Billot, L., Malavera, A., Faigle, R., Muñoz-Venturelli, P., Day, D., Liu, X., Li, Q., Song, L., Robinson, T. G., González, F., Urrutia-Goldsack, F., Iacobelli, M., Montalbano, M., Pruski, A. & Delcourt, C. & 621 others, Durham, A. C., Ebraimo, A., Van Ta, H. H., Ghosh, P., Leonhardt-Caprio, A., Nguyen, H. T., Ton, M. D., Jan, S., Liu, H., Lindley, R. I., Arauz, A., Mercado, A., Zaidi, W. A. W., Khatri, P., Wang, X., Urrutia, V. C., Jala, S., Day, S., Hu, Y., Lal, A., O'Brien, E., Devlin, M., Bendall, C., Nebauer, C., Maddox, D., Brooks, M., Kleinig, T., Cranefield, J., McMahon, S., Drew, R., McMullan, P., Straha, J., Rowley, D., Rodgers, H., Pyman, J., Grimley, R., Tastula, K., Li, X., Walker, S., Bailey, A., Hennessey, J. R., Butcher, K. S., Ghia, D., Edmonds, G., Casey, E., Ting, L., Prosser, J., Franklin, K., Ma, H., Phan, T., Vuong, J., Urbi, B., Phair, R., Jose, N., Shine, A., Lane, S., Mai, J., O'Rourke, F., Fuller, C., Urkude, R., Myers, N., Bradford, N., Sui, Y., Bian, W., Guo, X., Zhao, Y., Zhang, Y., Qi, X., Zhang, Y., Tang, H., Fang, X., Zheng, M., Yan, M., Yin, Y., Shi, P., Li, J., Luo, J., Fan, F., Guo, X., Zhou, H., Ba, X., Nie, Y., Song, C., Gao, H., Sun, L., Jia, C., Wang, M., Zhang, L., Yang, J., Song, A., Zhang, Y., Yu, S., Guan, Y., Bai, R., Li, C., Bai, T., Li, X., Wang, D., Yu, H., Zhao, W., Li, N., L, H., Yan, T., Zhang, J., Jiang, S., Shen, Y., Hu, X., Li, R., Cui, L., Kong, Y., Zhang, H., Yang, S., Guo, G., Zhao, X., Zhao, H., Zhang, F., Li, S., Yang, Y., Wang, Y., Jin, H., Liu, Z., Jiang, P., Jiang, H., Shai, Y., Tang, Y., Xue, J., Dong, X., Wang, J., Guo, J., Wang, X., Bao, Y., Li, H., Yang, X., Xie, L., Zhang, S., Yang, X., Qu, M., Deng, D., Liu, J., Bao, Z., Wang, T., Lin, L., Bi, C., Pan, Y., Chen, X., Gao, N., Peng, B., Lu, G., Jiang, Z., Pan, Y., Kang, L., Zhu, C., Zhang, L., Liang, Y., Peng, H., Song, B., Xiao, L., Kuang, J., Lu, X., Liao, X., Tan, Z., Zeng, W., Lin, W., Zhou, E., Wu, J., Chen, Y., Liu, Y., Meng, L., Wang, Z., Liu, Y., Xu, X., Xu, W., Dai, Y., Dong, Y., Zhang, Y., Wang, X., Hai, Y., Li, Z., Pei, Y., Zheng, G., Li, C., Wang, Z., Shi, Y., Li, S., Liu, Z., Zhang, J., Cui, L., Zhao, X., Qiao, Y., Liu, L., Zhang, J., Jiang, C., Fang, C., Su, R., Zhang, C., Ren, Y., Zhang, L., Liu, Y., Dong, M., Yang, T., Gao, S., Yin, R., Fu, Z., Li, Y., Ke, Y., Liu, X., Gao, H., Liu, Y., Wang, C., Liu, Y., Zhang, B., Guo, Z., Tan, Q., Zhong, W., Ling, K., Ma, S., Cheng, Y., Bi, Y., Jiang, F., Hao, Y., Yao, X., Wang, Z., Lei, M., Lei, L., Yue, D., Xiao, H., Chen, S., Chao, Y., He, G., Li, Y., Lin, M., Lv, J., Liu, C., Feng, J., Zhao, X., Yang, X., Yu, H., Ma, N., Lu, X., Jiang, R., Sun, X., Liu, N., Zhuang, Y., Silva-Pozo, A., Silva, P. G., Carrera, N. C., Mazzon, E., Brunser, A., Brinck, P., Gallardo, A., Gonzalez Valdivieso, P., Almeida, J., Sanhueza Neira, O., Haleby, A., Letelier Durán, A., Wenger, D., Canales, P., Zambrano, K., Rojas, C., Rocha Jiménez, D., Rivera, M., Jose Orellana, M., Polanco, J., Esparza, T., Asyraf, W., Jan Tan, T. H., Remli, R., Nafisah Wan Yahya, W. N., Soong, K. C., Kang, L. Z., Sahibulddin, S. Z., Binti Awang Baki, D. A., Hassan, H., Rahmat, N. L., Mohd Khaili, N. A., Rajah, R., Kiem, T. J., Khan Yusof Khan, A. H., Rauf, A. L. A., Zakaria, S. H., Halim, S. A., Abdullah, J. M., Idris, Z., Bin Baharuddin, K. A., Ismail, M. I., Wan Chung, L., Shyang, T. J., Steven, A., Cheng, W. S., Yang, S. C., Ong, S., James, J., Looi, I., Arauz, A., Mercado-Pompa, A., Cano-Nigenda, V., Romero-Vucovich, R., Nava-Sánchez, P., López-Pizano, A., Herrera-Calderón, R. E., Góngora-Rivera, F., Infante-Valenzuela, A., López-Soto, R., Chávez-Gamboa, R., Arreola-Sánchez, L. D., Gonzalez Gonzalez, G., León Vallejo, S., Galvez Romero, J. L., Marquez Estudillo, M. D. R., Reyes Ortega, D., Jiménez-Ruiz, A., Ruiz-Sandoval, J. L., Aguilar-Fuentes, V., Sotelo-Ramirez, J. A., Ascencio-Tene, R. G., De la Cruz Estrada, E., Perez, V. M., Mai, D. T., Dao, V. P., Nguyen, T. D., Le, T. A., Bui, Q. V., Nga Nguyen, T. P., Uyen Le, T. T., Nhung Tran, T. N., Nguyen, T. H., Nguyen, Q. H., Chien Vo, D., Tran, T. T., Phuong Nguyen, T. M., Cao, H. N., Nguyen, L. T., Thang Nguyen, H., Pham, N. B., An Nguyen, T. T., Dang, Q. H., Anh Nguyen, T. K., Thanh Vu, T., Le, T. V., Le, C. T., Thao Dang, N. M., Trang Nguyen, T. T., Teal, R., Joseph, J., Mathieson, P., Kennedy, J., Comont, T., Cumberbatch, G., Castanheira, A. M., Sim, C. H., Ghatala, R., Kennedy, K., Sari, B., Minhas, J., Musarrat, K., Khan, S., Harris, T., Mitchell-Douglas, J., Agarwal, S., Iqbal, A., Kowalska, K., McGovern, A., Stanton, J., Marinescu, M., Feerick, S., Obarey, S., Raingold, G., Flanagan, K., Revilla, G. A., Avila, R., Kennedy, R., Lee, Y. C., Lyon, J., Lewis, A., El Sayed, R., Jannine, Bandiola, B., Vincent Sese, L., Babia, K., Nungu, Z., Timotec, J., Drysdale, S., Tibasia, M. C., Domingos Belo, C., Bayhonan Rubern, S., Sari, B., Naqvi, A., Richards, E., Howe, J., Kamara, C., Younis, S., Sundayi, S., Sekaran, L., Reid, L., David, J., Poolon, L., Carpenter, M. A., Venkatesh, B., Kimaru, C. W., Greaves, C., Watson, S. E., Ryan, D., Kearsley, N., Temple, N., Allen, K., Arcoria, D., Horne, Z., Veraque, E., Zhao, J., Evans, S., Baird, A., Hannam-Penfold, T., Smith, S., Hutchinson, C., Hedstorm, A., Gray, L., Jones, R., Taylor, T., Oduh, B., Ahmad, N., Evans, R., Erumere, E., Sanders, B., Kinsella-Perks, E., Villa, K., Keenan, S., Finch, S., Page, R., Topliss, L., Duraisami, T., Pattenden, T., Morgan, K., Williams, E., Yeo, N., Mariampillai, S., Penn, R., Castillo, M., Cook, N., Campbell, S., Palit, S., Tench, H., Loosley, R., Sims, T., Wolf-Roberts, R., Parker, C., Kumar Subbarayan, S., O'Brien, L., Riddell, V., Smith, A., Price, C., Garside, M., Jensen, N., Duodu, Y., Padilla-Harris, C., Avila Del Puerto, P., Esisi, B., Clarkson, E., Murrey, M., Rai, V., Heckathorn, M., Bartelt, H., Hill, M., Akhmedova, D., Silver, B., Manxhari, C., Thompson, T., Manxhari, M., Leonhardt-Caprio, A., Prentiss, E., Benesch, C., Hepple, P., Reichwein, R., Velasco, C., Singer, A., Cekovich, E., Richardson, A., Christman, O., Kishel, L., Ahmed, I., Braklow, J., Smith, R., McMahon, J., Rossi, C., Graves, A., Schafer, J., Lynch, J., Giambartolomei, S., Aguilar, M., Ortiona, M., Dienst, E., Olds, K., Summers, D., Kennish, C., Mathiesen, C., Conahan, E., Rai, V., Heckathorn, M., Bartelt, H., Hill, M., Akhmedova, D., Sethi, P., Biby, S., Carter, A., Buckner, J., Kirkpatrick, M., Xu, J., Blackburn, T., Bell, H., Newnam, K., Mack, H., Hocutt, S., Altaweel, L., Chaudhry, S., Madarász, L., Smith, K., Belardo, S., Karageyer, T., Alexander, M., Hagedorn, D., Westensee, N., Cohen, L., Wiegand, T., (Hughes) Barghols, J., Wheeler, R., Smith, K., Stilwell, K., Urrutia, V., Johnson, B., Butler, J., Faigle, R., AlShekhlee, A., Ezepue, C., Gatscher, B., King, R., Ke, M., Dow, G., Seamon, M., Smith, T., Tabaac, B., Gurnea, K., Webb, J., Phipps, M., Schrier, C., Leonhardt-Caprio, A., Prentiss, E., Silverman, B., Green, N., Kelly, J., Froehlich, L., Anderson, C., Urrutia, V., Johnson, B., Summers, D., Faigle, R., Day, D., Robinson, T., Khatri, P., Lindley, R., Wang, X., Sui, Y., Song, L., Asyraf, W., Thang Nguyen, H., Herbert, R., Barreto, A., S. Rapp, K., Billot, L., Li, Q., Liu, X., Wang, Y., Han, Q., Ouyang, M., Liu, H., Xu, L., Jan, S., Tang, R., Montalbano, M., Pruski, A., González, F., Day, D., Del Rio Weldt, A., López Pizano, A. J., Zaleha Sahibulddin, S., Rahmat, N. L., Mohd Khaili, N. A., Anis, D., Hassan, H., Ebraimo, A., J. Injety, R., Malavera, A., Ta, H. H. V., Ghosh, P., Espinosa, N., Clancy, L., Byrne, A., Hatchwell, L., Hurden, A., Michell, A., Armenis, M., Tummapudi, R., Arabhavi, U., Ouyang, M., Cheng, J., Meng, Z., Durham, A., Ebraimo, A., Hong, U., Thi My, L. L., Ha, N. N., Van, T. T., Nhung, T. K., Mai, T., Ha, N. P., Giang, T. H., Linh, N., Chi, T. K., Nhi, T., Thanh, H. N., González, F., Urrutia Goldsack, F. & Del Rio Weldt, A., May 31 2025, In: The Lancet. 405, 10493, p. 1909-1922 14 p.

      Research output: Contribution to journal › Article › peer-review

      3 Scopus citations

    • Vaccination against COVID-19 and Outcomes in Patients with COVID-19 Infection and Stroke

      El Seblani, N., Gorenflo, M. P., Ortega-Gutierrez, S., Reichwein, R. K., Xu, R. & Nagaraja, N., Dec 2025, In: npj Vaccines. 10, 1, 133.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Conscious sedation by sedation-trained interventionalists versus anesthesia providers in patients with acute ischemic stroke undergoing endovascular thrombectomy: A propensity score-matched analysis

      Padmanaban, V., Grzyb, C., Velasco, C., Richardson, A., Cekovich, E., Reichwein, R., Church, E. W., Wilkinson, D., Simon, S. & Cockroft, K., 2023, (Accepted/In press) In: Interventional Neuroradiology.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Impact of COVID-19 Pandemic on the Incidence, Prehospital Evaluation, and Presentation of Ischemic Stroke at a Nonurban Comprehensive Stroke Center

      Velasco, C., Wattai, B., Buchle, S., Richardson, A., Padmanaban, V., Morrison, K. J., Reichwein, R., Church, E., Simon, S. D. & Cockroft, K. M., 2021, In: Stroke Research and Treatment. 2021, 6624231.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations

    • A CARASIL patient from americas with novel mutation and atypical features: Case presentation and literature review

      Ibrahimi, M., Nozaki, H., Lee, A., Onodera, O., Reichwein, R., Wicklund, M. & El-Ghanem, M., Oct 1 2017, In: Cerebrovascular Diseases. 44, 3-4, p. 135-140 6 p.

      Research output: Contribution to journal › Review article › peer-review

      18 Scopus citations
    View all 11 Research outputs