Projects per year
Personal profile
Research interests
Dr. Richard Mailman has had a decades-long interest in the design and discovery of novel dopamine receptor ligands. In 1994, his lab was also the first to discover, elaborate and name the major pharmacology research front now called functional selectivity, which is how drugs acting at a single receptor differentially activate or block selected signaling pathways of that receptor. His current research interest is focused on mechanisms of receptor signaling and how the resulting knowledge can be used for novel drugs with better therapeutic profiles. His research played a major role in the understanding of the mechanisms of action of aripiprazole and other third-generation antipsychotic drugs.
His special long-term interest has been a class of drug called dopamine D1 agonists. He led a team that discovered the first important D1 agonist that he took from the lab to experimental clinical studies. His lab and their collaborators are studying the mechanisms by which D1 agonists affect cognitive processes and how these effects might be used for treatment of disorders with cognitive impairment. and disorders like attention deficit/hyperactivity disorder (ADHD). The findings of his lab provided the foundation for several pharmaceutical companies to begin research in this area that now has led to recent industry-sponsored Phase II and Phase III clinical trials of D1 agonists. Working with a team from the College of Medicine's Translational Brain Research Center and the Department of Neurology's Division of Movement Disorders, they are breaking new ground in potential treatments for late-stage Parkinson's disease based on ideas from Dr. Mailman's lab.
Professional information
Dr. Richard Mailman is a College of Medicine Distinguished Senior Scholar
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Discovery of functionally selective dopamine ligands for age-related cognitive decline
Yang, Y., Dokholyan, N. & Mailman, R.
6/1/21 → 5/31/24
Project: Research project
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In vivo agonist molecular probes for the dopamine D1 receptor
Mailman, R. & Sharma, A. K.
National Institute of Neurological Disorders and Stroke
2/15/18 → 1/31/21
Project: Research project
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PROJECT2:Understanding of Functionally-Selective D2 Dopamine Receptor Ligands
Mailman, R. & Mailman, R. B.
National Institute of Mental Health
9/28/07 → 4/30/13
Project: Research project
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CORE 2: BIOCHEMICAL ASSAY CORE (MAILMAN)
Mailman, R. & Mailman, R. B.
National Institute of Mental Health
9/28/07 → 4/30/13
Project: Research project
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Functional Selectivity: A Novel Approach for CNS Drug Discovery
Roth, B. L., Caron, M. G., Jin, J., Mailman, R., Wetsel, W. C. & Mailman, R. B.
9/28/07 → 4/30/18
Project: Research project
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A noncommutative combinatorial protein logic circuit controls cell orientation in nanoenvironments
Chen, J., Vishweshwaraiah, Y. L., Mailman, R. B., Tabdanov, E. D. & Dokholyan, N. V., May 2023, In: Science Advances. 9, 21, eadg1062.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of behavioral changes in T-maze alternation from dopamine D1 agonists with different receptor coupling mechanisms
Cimino, J. X., Zhou, M., Waxmonsky, J., Mailman, R. B. & Yang, Y., Oct 2023, In: Psychopharmacology. 240, 10, p. 2187-2199 13 p.Research output: Contribution to journal › Article › peer-review
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Dopamine D1 Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease
Lewis, M. M., Van Scoy, L. J., De Jesus, S., Hakun, J. G., Eslinger, P. J., Fernandez-Mendoza, J., Kong, L., Yang, Y., Snyder, B. L., Loktionova, N., Duvvuri, S., Gray, D. L., Huang, X. & Mailman, R. B., May 2023, In: Biomolecules. 13, 5, 829.Research output: Contribution to journal › Article › peer-review
Open Access -
Higher hippocampal diffusivity values in welders are associated with greater R2* in the red nucleus and lower psychomotor performance
Lee, E. Y., Kim, J., Prado-Rico, J. M., Du, G., Lewis, M. M., Kong, L., Kim, B. G., Hong, Y. S., Yanosky, J. D., Mailman, R. B. & Huang, X., May 2023, In: NeuroToxicology. 96, p. 53-68 16 p.Research output: Contribution to journal › Article › peer-review
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Student Perceptions of a New Course Using Argumentation in Medical Education
Foy, A. J., Vrana, K. E., Haidet, P., Hausman, B. L., Adams, N. E., Ropson, I., Wolpaw, D. R., Rabago, D., Mailman, R. B. & Huang, X., 2023, In: Advances in Medical Education and Practice. 14, p. 989-998 10 p.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Career Citation Milestone Award - D (500) Club
Barber, Alistair (Recipient), Belani, Chandra (Recipient), Bixler, Edward (Recipient), Eslinger, Paul (Recipient), Imamura, Yuka (Recipient), Legro, Richard (Recipient), Mailman, Richard (Recipient), Schiff, Steven (Recipient), Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2019
Prize
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Dean's Award for Excellence in Teaching
Aber, Robert (Recipient), Anderson, Alyssa (Recipient), Aynardi, Michael (Recipient), Browning, Kirsteen (Recipient), Chen, Michael (Recipient), Chu, David C. (Recipient), Cios, Theodore (Recipient), Cruz, Amy (Recipient), Cruz, Jeffrey (Recipient), Dalal, Priti (Recipient), Dambro, Anthony (Recipient), Disori, Kristin (Recipient), Dodge, Daleela (Recipient), Duda, Laura (Recipient), Evey, Loren (Recipient), Fotos, Joseph (Recipient), Fredrick, N. Benjamin (Recipient), Freeman, Michael (Recipient), Gordin, Vitaly (Recipient), Graziane, Julie (Recipient), Hempel, Eliana (Recipient), Hennrikus, Eileen (Recipient), Horwitz, Alexandra (Recipient), Izer, Jenelle (Recipient), Jhaveri, Punit (Recipient), Kalantari, Annahieta (Recipient), Karpa, Kelly (Recipient), Kaur, Gurwant (Recipient), Keil, Ralph (Recipient), Khalid, M. Fahad (Recipient), Kimball, Scot (Recipient), Knoedler, John (Recipient), LaClair, Michelle (Recipient), Lam, Charlene (Recipient), LaRegina, Carol (Recipient), Lighthall, Jessyka (Recipient), Mailman, Richard (Recipient), McCormick, Jennifer (Recipient), McGinn, Johnathan (Recipient), McShane, Michael (Recipient), Millard, Roberta (Recipient), Myers, Abigail (Recipient), Nasir, Munima (Recipient), Oh, John (Recipient), Pathare, Aum (Recipient), Peterson, Brandon (Recipient), Potochny, John (Recipient), Roberts, S. Michael (Recipient), Romanoski, Natasha (Recipient), Ross, Stephen (Recipient), Rudnitsky, Gail (Recipient), Schade, Meredith (Recipient), Simmons, Zachary (Recipient), Smink, Gayle (Recipient), Stella, Salvatore (Recipient), Stephens, Mark (Recipient), Surapaneni, Sowmya (Recipient), Verbeek, Thomas (Recipient), Waning, David (Recipient), Williams, Emmanuelle (Recipient), Williams, Duane (Recipient), Wilson, Mary Ellen (Recipient), Zaorsky, Nicholas (Recipient) & Lutzkanin, Andrew (Recipient), 2020
Prize
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Dean's Award for Excellence in Teaching
McAlevy, Mary (Recipient), Bonavia, Anthony (Recipient), Malhotra, Anita (Recipient), Weller, Gregory E. (Recipient), Waning, David (Recipient), Lanza, Matthew (Recipient), Ken, Kimberly (Recipient), McCarver, Stewart (Recipient), Glasser, Joshua (Recipient), Schooler, Jordan (Recipient), Lewis, Sarah (Recipient), Onks, Cayce (Recipient), Rao, Ravishankar (Recipient), Nickolich, Sarah (Recipient), Helm, Leesha (Recipient), Critchfield, Laura (Recipient), Myers, Kimberly (Recipient), Green, Michael (Recipient), Songdej, Natthapol (Recipient), Narayana, Shyam (Recipient), Razjouyan, Hadie (Recipient), Duca, Nicholas (Recipient), Casas, Rachel (Recipient), Cooper, Jennifer (Recipient), Wright, Rollin (Recipient), Karasinski, Amanda (Recipient), Probolus, James Andrew "Andy" (Recipient), Madara, John (Recipient), Guck, Daniel (Recipient), Ingram, David (Recipient), De Obaldia, Anna (Recipient), Hussein, Rezhan (Recipient), McGillen, Brian (Recipient), Chapman, Tyler (Recipient), Munyon, Ryan (Recipient), Kinard, Shane R. (Recipient), Banks, Sharon (Recipient), Genao, Inginia (Recipient), McShane, Michael (Recipient), Allie, S. Rameeza (Recipient), Silberman, Yuval (Recipient), Evey, Loren (Recipient), McLaughlin, Patricia (Recipient), Grogan, James (Recipient), Nguyen, Joseph (Recipient), Donato, Heather (Recipient), Fox, Edward (Recipient), Gniady, John (Recipient), Oladipo, Olajumoke (Recipient), Abendroth, Catherine (Recipient), Keefer, Laura (Recipient), Massare, Brittany (Recipient), Undar, Akif (Recipient), Mondal, Pritish (Recipient), Mainali, Gayatra (Recipient), Jhaveri, Pooja (Recipient), Freiberg, Andrew (Recipient), Levenson, Robert (Recipient), Mailman, Richard (Recipient), Boodoo, Ramnarine (Recipient), Francis, Andrew (Recipient), Hameed, Usman (Recipient), Yadav, Sanjay (Recipient), Calo, William (Recipient), Pinto, Casey (Recipient), Cooper, Amanda (Recipient), Kulaylat, Audrey (Recipient), Scow, Jeffrey (Recipient), Roberts, John (Recipient), Winder, Joshua (Recipient), Aminsharifi, Alireza (Recipient), Adams, Nancy (Recipient) & van Riggelen, Jan (Recipient), 2023
Prize