Projects per year
Personal profile
Research interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
Teaching and educational interests
Dr. Shengyu Yang is co-directing a new course for medical students at Penn State College of Medicine, Mitochondria in Physiology and Diseases, with Dr. Katherine Aird.
Dr. Yang also lectures on receptor tyrosine kinase signaling, cancer metastasis and mitochondrial dynamics to graduate students.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Fellowship, Weill Cornell Medical College
… → 2010
Biophysics, PhD, Chinese Academy of Science
… → 2001
BS, Xiamen University
… → 1996
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Collaborations and top research areas from the last five years
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Projects
- 1 Finished
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Store-operated calcium entry in tumor invasion and metastasis
Yang, S. (CoPI) & Yang, S. (PI)
12/3/13 → 11/30/19
Project: Research project
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BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism
Sun, H., Li, H., Guan, Y., Yuan, Y., Xu, C., Fu, D., Xie, P., Li, J., Zhao, T., Wang, X., Feng, Y., Wang, H., Gao, S., Yang, S., Shi, Y., Liu, J., Chang, A., Huang, C. & Hao, J., Jun 2024, In: Science Advances. 10, 25, eadj8650.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (271), 10.1038/s41392-023-01478-5)
Huang, C., Li, H., Xu, Y., Xu, C., Sun, H., Li, Z., Ge, Y., Wang, H., Zhao, T., Gao, S., Wang, X., Yang, S., Sun, P., Liu, Z., Liu, J., Chang, A. & Hao, J., Dec 2024, In: Signal Transduction and Targeted Therapy. 9, 1, 8.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression
Javed, Z., Shin, D. H., Pan, W., White, S. R., Elhaw, A. T., Kim, Y. S., Kamlapurkar, S., Cheng, Y. Y., Benson, J. C., Abdelnaby, A. E., Phaeton, R., Wang, H. G., Yang, S., Sullivan, M. L. G., St.Croix, C. M., Watkins, S. C., Mullett, S. J., Gelhaus, S. L., Lee, N. & Coffman, L. G. & 5 others, , Oct 10 2024, In: EMBO Reports. 25, 10, p. 4281-4310 30 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
Ling, H., Li, Y., Peng, C., Yang, S. & Seto, E., Jun 1 2024, In: NAR Cancer. 6, 2, zcae018.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial deoxyguanosine kinase is required for female fertility in mice
Gao, Y., Dong, R., Yan, J., Chen, H., Sang, L., Yao, X., Fan, D., Wang, X., Zuo, X., Zhang, X., Yang, S., Wu, Z. & Sun, J., 2024, In: Acta Biochimica et Biophysica Sinica. 56, 3, p. 427-439 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations