Projects per year
Personal profile
Research interests
Dr. Spencer Szczesny heads the Multiscale Biomechanics and Mechanobiology Lab, which is part of the departments of Biomedical Engineering and Orthopaedics and Rehabilitation at Penn State. His research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair and development). The ultimate goals of his work are to identify the causes of tendon pathology, discover novel therapeutic options and direct the design of biomaterials that can recapitulate the behavior of native tissue. This multidisciplinary research involves the use of multiscale mechanical testing, computational modeling, cell and tissue culture and biomaterial fabrication.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Pennsylvania
… → May 2015
MS, Massachusetts Institute of Technology
… → May 2005
BS, University of Pennsylvania
… → May 2003
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Collaborations and top research areas from the last five years
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CAREER: Studying Tendon Cell Mechanobiology in the Native Tissue Environment
8/1/22 → 7/31/27
Project: Research project
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Colocalization of gene expression and microscale tissue strains in live tendon explants using barcoded biosensors
Szczesny, S. & Wong, P. K. P.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2/1/22 → 12/31/23
Project: Research project
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Identifying Mechanobiological Deficits in Allograft Anterior Cruciate Ligament Reconstructions
8/1/21 → …
Project: Research project
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Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner
Paschall, L., Carrozzi, S., Tabdanov, E., Dhawan, A. & Szczesny, S. E., 2023, (Accepted/In press) In: Journal of Orthopaedic Research.Research output: Contribution to journal › Article › peer-review
Open Access -
Incorporating an Education Module on Diversity, Equity, and Inclusion into Undergraduate and Graduate Curricula Has No Positive Effect on Women's Perception of Biomedical Engineering
Szczesny, S., Salazar, A. & Casasanta, A. C., Jun 25 2023, In: ASEE Annual Conference and Exposition, Conference Proceedings.Research output: Contribution to journal › Conference article › peer-review
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Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
Godshall, S., Pedaprolu, K., Vasti, E., Eskandari, F. & Szczesny, S. E., Jan 2023, In: Journal of Visualized Experiments. 2023, 191, e64921.Research output: Contribution to journal › Article › peer-review
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Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure
Pedaprolu, K. & Szczesny, S. E., Apr 2023, In: Journal of Biomechanics. 151, 111545.Research output: Contribution to journal › Article › peer-review
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Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation
Lee, K., Davis, B., Wang, X., Mirg, S., Wen, C., Abune, L., Peterson, B. E., Han, L., Chen, H., Wang, H., Szczesny, S. E., Lei, Y., Kothapalli, S. R. & Wang, Y., Aug 1 2023, In: Angewandte Chemie - International Edition. 62, 31, e202306583.Research output: Contribution to journal › Article › peer-review
Open Access