Personal profile
Research interests
Dr. Spencer Szczesny heads the Multiscale Biomechanics and Mechanobiology Lab, which is part of the departments of Biomedical Engineering and Orthopaedics and Rehabilitation at Penn State. His research investigates the interplay between tendon multiscale mechanics and mechanobiology in the context of tissue remodeling (e.g., degeneration, repair and development). The ultimate goals of his work are to identify the causes of tendon pathology, discover novel therapeutic options and direct the design of biomaterials that can recapitulate the behavior of native tissue. This multidisciplinary research involves the use of multiscale mechanical testing, computational modeling, cell and tissue culture and biomaterial fabrication.
Education/Academic qualification
PhD, University of Pennsylvania
… → May 2015
MS, Massachusetts Institute of Technology
… → May 2005
BS, University of Pennsylvania
… → May 2003
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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CAREER: Studying Tendon Cell Mechanobiology in the Native Tissue Environment
Szczesny, S. (PI)
8/1/22 → 7/31/27
Project: Research project
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US-Ireland R&D Partnership: Design of Genetically Engineered Tensile Load-Bearing Soft Tissues Inspired by Embryonic Tendon Development
Szczesny, S. (PI)
1/1/22 → 12/31/26
Project: Research project
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Identifying Mechanobiological Deficits in Allograft Anterior Cruciate Ligament Reconstructions
Szczesny, S. (PI)
8/1/21 → …
Project: Research project
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Identifying Mechanobiological Deficits in Allograft Anterior Cruciate Ligament Reconstructions
Szczesny, S. (PI)
Congressionally Directed Medical Research Programs
1/1/20 → …
Project: Research project
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Identifying Mechanobiological Deficits in Allograft Anterior Cruciate Ligament Reconstructions
Szczesny, S. (PI)
1/1/20 → …
Project: Research project
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The Journal of Biomechanical Engineering Remains Committed to Supporting Scholarship Through the Promotion of Diversity, Equity, and Inclusion
Dickerson, D. & Szczesny, S. E., Mar 1 2026, In: Journal of Biomechanical Engineering. 148, 3, 030301.Research output: Contribution to journal › Review article › peer-review
Open Access -
Allograft and autograft anterior cruciate ligament reconstructions exhibit a similar biological response to cyclic loading
Paschall, L., Tsai, A., Tabdanov, E., Negrini, K., Izer, J., Dhawan, A. & Szczesny, S. E., 2025, In: Connective Tissue Research. 66, 1, p. 37-48 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Bubbler System Design for Regulating Media Oxygen Levels in an Open Testing Environment
Capalbo, M. H. & Szczesny, S. E., Aug 1 2025, In: Journal of Biomechanical Engineering. 147, 8, 084503.Research output: Contribution to journal › Article › peer-review
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Female Anterior Cruciate Ligaments Exhibit a Muted Mechanobiological Response to Mechanical Loading
Paschall, L., Konnaris, M., Tabdanov, E., Dhawan, A. & Szczesny, S. E., Dec 2025, In: Journal of Orthopaedic Research. 43, 12, p. 2188-2202 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cyclic loading induces anabolic gene expression in ACLs in a load-dependent and sex-specific manner
Paschall, L., Carrozzi, S., Tabdanov, E., Dhawan, A. & Szczesny, S. E., Feb 2024, In: Journal of Orthopaedic Research. 42, 2, p. 267-276 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations