Research output per year
Research output per year
- 350 - 400 out of 638 results
Search results
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1994
Catalytic antibodies: Perusing combinatorial libraries
Posner, B., Smiley, J., Lee, I. & Benkovic, S., Apr 1994, In: Trends in Biochemical Sciences. 19, 4, p. 145-150 6 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization
Roberts, V. A., Stewart, J., Benkovic, S. J. & Getzoff, E. D., Jan 20 1994, In: Journal of Molecular Biology. 235, 3, p. 1098-1116 19 p.Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
Cloning and Characterization of a New Purine Biosynthetic Enzyme: A Non-Folate Glycinamide Ribonucleotide Transformylase from E. coli
Marolewski, A., Smith, J. M. & Benkovic, S. J., Mar 1 1994, In: Biochemistry. 33, 9, p. 2531-2537 7 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Creation of a Novel Biosensor for Zn(II)
Stewart, J. D., Roberts, V. A., Crowder, M. W., Getzoff, E. D. & Benkovic, S. J., Jan 1 1994, In: Journal of the American Chemical Society. 116, 1, p. 415-416 2 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Dissection of an antibody-catalyzed reaction
Stewart, J. D., Krebs, J. F., Siuzdak, G., Berdis, A. J., Smithrud, D. B. & Benkovic, S. J., Aug 2 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 16, p. 7404-7409 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access50 Scopus citations -
Dynamics of a Flexible Loop in Dihydrofolate Reductase from Escherichia coli and Its Implication for Catalysis
Falzone, C. J., Benkovic, S. J. & Wright, P. E., Jan 1 1994, In: Biochemistry. 33, 2, p. 439-442 4 p.Research output: Contribution to journal › Article › peer-review
148 Scopus citations -
Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase
Gopalakrishnan, V. & Benkovic, S., Feb 11 1994, In: Journal of Biological Chemistry. 269, 6, p. 4110-4115 6 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Fidelity of in Vitro DNA Strand Transfer Reactions Catalyzed by HIV-1 Reverse Transcriptase
Peliska, J. A. & Benkovic, S. J., Apr 1 1994, In: Biochemistry. 33, 13, p. 3890-3895 6 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Identification of Metal Ligands in Cu(II)-Inhibited Chromobacterium violaceum Phenylalanine Hydroxylase by Electron Spin Echo Envelope Modulation Analysis of Histidine to Serine Mutations
Balasubramanian, S., Carr, R. T., Benkovic, S. J., Bender, C. J. & Peisach, J., Jul 1 1994, In: Biochemistry. 33, 28, p. 8532-8537 6 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Nonadditivity of Mutational Effects at the Folate Binding Site of Escherichia coli Dihydrofolate Reductase
Huang, Z., Wagner, C. R. & Benkovic, S. J., Sep 1 1994, In: Biochemistry. 33, 38, p. 11576-11585 10 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten
Smith, A. B., Taylor, C. M., Benkovic, S. J. & Hirschmann, R., Sep 12 1994, In: Tetrahedron Letters. 35, 37, p. 6853-6856 4 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids
Hirschmann, R., Smith, A. B., Taylor, C. M., Benkovic, P. A., Taylor, S. D., Yager, K. M., Sprengeler, P. A. & Benkovic, S. J., Jul 8 1994, In: Science. 265, 5169, p. 234-237 4 p.Research output: Contribution to journal › Article › peer-review
424 Scopus citations -
Recombinant HIV-1 Nucleocapsid Protein Accelerates HIV-1 Reverse Transcriptase Catalyzed DNA Strand Transfer Reactions and Modulates RNase H Activity
Peliska, J. A., Balasubramanian, S., Giedroc, D. P. & Benkovic, S. J., Nov 1 1994, In: Biochemistry. 33, 46, p. 13817-13823 7 p.Research output: Contribution to journal › Article › peer-review
163 Scopus citations -
Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli. Antibodies for orotate decarboxylation
Smiley, J. A. & Benkovic, S. J., Aug 30 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 18, p. 8319-8323 5 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
Site-Directed Mutagenesis of a Catalytic Antibody: An Arginine and a Histidine Residue Play Key Roles
Stewart, J. D., Roberts, V. A., Thomas, N. R., Getzoff, E. D. & Benkovic, S. J., Mar 1 1994, In: Biochemistry. 33, 8, p. 1994-2003 10 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
Spatial relationship between polymerase and exonuclease active sites of phage T4 DNA polymerase enzyme
Gopalakrishnan, V. & Benkovic, S. J., Aug 19 1994, In: Journal of Biological Chemistry. 269, 33, p. 21123-21126 4 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
1993
A Catalytic Antibody for Imide Hydrolysis Featuring a Bifunctional Transition-State Mimic
Liotta, L. J., Benkovic, P. A., Miller, G. P. & Benkovic, S. J., Jan 1 1993, In: Journal of the American Chemical Society. 115, 1, p. 350-351 2 p.Research output: Contribution to journal › Editorial › peer-review
38 Scopus citations -
An Examination of the Copper Requirement of Phenylalanine Hydroxylase from Chromobacterium violaceum
Carr, R. T. & Benkovic, S., 1993, In: Biochemistry. 32, 51, p. 14132-14138 7 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
A re-examination of the metal requirement of Chromobacterium violaceum phenylalanine hydroxylase
Carr, R. T. & Benkovic, S. J., 1993, In: Advances in experimental medicine and biology. 338, p. 63-66 4 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
A revised strategy for cloning antibody gene fragments in bacteria
Posner, B., Lee, I., Itoh, T., Pyati, J., Graff, R., Thorton, G. B., La Polla b, R. & Benkovic, S. J., Jun 15 1993, In: Gene. 128, 1, p. 111-117 7 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Catalytic antibodies: Mechanistic and practical considerations
Stewart, J. D. & Benkovic, S. J., 1993, In: Chemical Society Reviews. 22, 4, p. 213-219 7 p.Research output: Contribution to journal › Review article › peer-review
42 Scopus citations -
Catalytic antibody model and site-directed mutagenesis implicate arginine and histidine in catalytic mechanism
Roberts, V. A., Getzoff, E. D., Stewart, J. & Benkovic, S. J., 1993, In: Protein Engineering, Design and Selection. 6, p. 85 1 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3′ → 5′ exonuclease activity
Frey, M. W., Nossal, N. G., Capson, T. L. & Benkovic, S. J., Apr 1 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 7, p. 2579-2583 5 p.Research output: Contribution to journal › Article › peer-review
122 Scopus citations -
Corrections: X-ray Absorption Studies of the Cu-Dependent Phenylalanine Hydroxylase from Chromobacterium violaceum. Comparison of the Copper Coordination in Oxidized and Dithionite-Reduced Enzymes (Biochemistry (1992) 31(23) (5298–5303) (10.1021/bi00138a008))
Blackburn, N. J., Strange, R. W., Carr, R. T. & Benkovic, S., Jan 1 1993, In: Biochemistry. 32, 35, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites
Gibbs, B. S., Wojchowski, D. & Benkovic, S. J., Apr 15 1993, In: Journal of Biological Chemistry. 268, 11, p. 8046-8052 7 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Histidines 138 and 143 are copper binding ligands in Chromobacterium violaceum phenylalanine hydroxylase
Balasubramanian, S., Carr, R. T., Bender, C. J., Peisach, J. & Benkovic, S. J., 1993, In: Advances in experimental medicine and biology. 338, p. 67-70 4 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct
Kaboord, B. F. & Benkovic, S. J., Nov 15 1993, In: Proceedings of the National Academy of Sciences of the United States of America. 90, 22, p. 10881-10885 5 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Reaction Mechanisms Displayed by Catalytic Antibodies
Stewart, J. D., Liotta, L. J. & Benkovic, S., Aug 1 1993, In: Accounts of Chemical Research. 26, 8, p. 396-404 9 p.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
Recent developments in catalytic antibodies
Stewart, J. D. & Benkovic, S. J., 1993, In: International Reviews of Immunology. 10, 2-3, p. 229-240 12 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Recent trends in catalytic antibody research
Stewart, J. D. & Benkovic, S., Jan 1 1993, In: Drug News and Perspectives. 6, 7, p. 522-531 10 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
1992
A handy enzyme for transcription
Peliska, J. A. & Benkovic, S. J., Oct 1992, In: Current Biology. 2, 10, p. 521-523 3 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Antibody-catalyzed rearrangement of the peptide bond
Gibbs, R. A., Taylor, S. & Benkovic, S. J., Oct 30 1992, In: Science. 258, 5083, p. 803-805 3 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Catalytic antibodies
Benkovic, S. J., 1992, In: Annual review of biochemistry. 61, p. 29-54 26 p.Research output: Contribution to journal › Review article › peer-review
139 Scopus citations -
Complementary Perturbation of the Kinetic Mechanism and Catalytic Effectiveness of Dihydrofolate Reductase by Side-Chain Interchange
Wagner, C. R., Thillet, J. & Benkovic, S. J., Feb 1 1992, In: Biochemistry. 31, 34, p. 7834-7840 7 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3·0 Å resolution. A target enzyme for chemotherapy
Chen, P., Schulze-Gahmen, U., Stura, E. A., Inglese, J., Johnson, D. L., Marolewski, A., Benkovic, S. J. & Wilson, I. A., Sep 5 1992, In: Journal of Molecular Biology. 227, 1, p. 283-292 10 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
Editorial overview
Ebans, P. R. & Benkovic, S. J., Oct 1992, In: Current Opinion in Structural Biology. 2, 5, p. 711-712 2 p.Research output: Contribution to journal › Editorial › peer-review
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Functional Role of a Mobile Loop of Escherichia coli Dihydrofolate Reductase in Transition-State Stabilization
Li, L., Falzone, C. J., Benkovic, S. J. & Wright, P. E., Feb 1 1992, In: Biochemistry. 31, 34, p. 7826-7833 8 p.Research output: Contribution to journal › Article › peer-review
102 Scopus citations -
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. 1989.
Huse, W. D., Sastry, L., Iverson, S. A., Kang, A. S., Alting-Mees, M., Burton, D. R., Benkovic, S. J. & Lerner, R. A., 1992, In: Biotechnology (Reading, Mass.). 24, p. 517-523 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Human immunodeficiency virus type 1 reverse transcriptase: Spatial and temporal relationship between the polymerase and RNase H activities
Gopalakrishnan, V., Peliska, J. A. & Benkovic, S. J., 1992, In: Proceedings of the National Academy of Sciences of the United States of America. 89, 22, p. 10763-10767 5 p.Research output: Contribution to journal › Article › peer-review
180 Scopus citations -
Kinetic Characterization of the Polymerase and Exonuclease Activities of the Gene 43 Protein of Bacteriophage T4
Capson, T. L., Peliska, J. A., Kaboord, B. F., Frey, M. W., Lively, C., Dahlberg, M. & Benkovic, S. J., Feb 1 1992, In: Biochemistry. 31, 45, p. 10984-10994 11 p.Research output: Contribution to journal › Article › peer-review
238 Scopus citations -
Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
Peliska, J. A. & Benkovic, S. J., Nov 13 1992, In: Science. 258, 5085, p. 1112-1118 7 p.Research output: Contribution to journal › Article › peer-review
310 Scopus citations -
Minimal Kinetic Mechanism for Misincorporation by DNA Polymerase I (Klenow Fragment)
Eger, B. T. & Benkovic, S. J., Feb 1 1992, In: Biochemistry. 31, 38, p. 9227-9236 10 p.Research output: Contribution to journal › Article › peer-review
77 Scopus citations -
Probing the Molecular Basis of Resistance to Pyrimethamine by Site-Directed Mutagenesis
Wagner, C. R. & Benkovic, S. J., Jul 1 1992, In: Journal of Medicinal Chemistry. 35, 15, p. 2912-2915 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli
Polesky, A. H., Dahlberg, M. E., Benkovic, S. J., Grindley, N. D. F. & Joyce, C. M., Apr 25 1992, In: Journal of Biological Chemistry. 267, 12, p. 8417-8428 12 p.Research output: Contribution to journal › Article › peer-review
188 Scopus citations -
Substituent Effects on an Antibody-Catalyzed Hydrolysis of Phenyl Esters: Further Evidence for an Acyl-Antibody Intermediate
Gibbs, R. A., Benkovic, P. A., Janda, K. D., Lerner, R. A. & Benkovic, S. J., Apr 1 1992, In: Journal of the American Chemical Society. 114, 9, p. 3528-3534 7 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
X-ray Absorption Studies of the Cu-Dependent Phenylalanine Hydroxylase from Chromobacterium violaceum. Comparison of the Copper Coordination in Oxidized and Dithionite-Reduced Enzymes
Blackburn, N. J., Strange, R. W., Carr, R. T. & Benkovic, S. J., Feb 1 1992, In: Biochemistry. 31, 23, p. 5298-5303 6 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
1991
A catalytic antibody uses a multistep kinetic sequence.
Benkovic, S., Adams, J., Janda, K. D. & Lerner, R. A., 1991, In: Ciba Foundation symposium. 159, p. 4-9; discussion 9-912Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Affinity Labeling of the Active Site and the Reactive Sulfhydryl Associated with Activation of Rat Liver Phenylalanine Hydroxylase
Gibbs, B. S. & Benkovic, S. J., Jul 1 1991, In: Biochemistry. 30, 27, p. 6795-6802 8 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
A Mutant of DNA Polymerase I (Klenow Fragment) with Reduced Fidelity
Carroll, S. S., Cowart, M. & Benkovic, S. J., Jan 1 1991, In: Biochemistry. 30, 3, p. 804-813 10 p.Research output: Contribution to journal › Article › peer-review
124 Scopus citations -
A Novel Combined Chemical–Enzymatic Synthesis of Cross-Linked DNA Using a Nucleoside Triphosphate Analogue
Cowart, M. & Benkovic, S. J., Jan 1 1991, In: Biochemistry. 30, 3, p. 788-796 9 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations