Projects per year
Personal profile
Research interests
Dr. Todd Schell's research focuses on defining immune-based therapies for cancer. His interests include evaluating approaches to improve the persistence and function of tumor-reactive T lymphocytes within the tumor microenvironment. These studies have defined how tumor-reactive T-cells behave in distinct types of cancer including those that occur in the brain, pancreas, prostate and skin. Emphasis is placed on the use of adoptive T-cell therapies as well as defining how existing immune-based therapies currently used in cancer patients can be further improved.
Recent studies from the Schell laboratory highlight how antibody-based therapies targeting CD40 or PD-1 can be improved through combination with existing approaches such as radiation or common medications such as beta-blockers. Through collaborations with clinical investigators, translational studies focus on identification of patient characteristics that are associated with durable clinical responses to immune-based therapies, particularly for metastatic melanoma.
In addition to his research, Dr. Schell is the faculty director of Penn State College of Medicine's Flow Cytometry Core Facility.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoctoral Training, Penn State College of Medicine
… → 1999
PhD, West Viginia University School of Medicine
… → 1995
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Collaborations and top research areas from the last five years
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Targeting Aldehyde Dehydrogenase for Cancer Prevention
Robertson, G., Amin, S. & Schell, T.
4/15/20 → 3/31/24
Project: Research project
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Neuroendocrine Modulation of T Cell Immunity to Cancer
Schell, T. D. & Schell, T.
National Institute of Allergy and Infectious Diseases
6/1/09 → 5/31/10
Project: Research project
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CD8+ T Cell-Mediated Immunotherapy of Autochthonous SV40 T Antigen-Induced Tumors
Schell, T. & Tevethia, S. S.
6/1/85 → 11/30/15
Project: Research project
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Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023
Joshi, M., Tuanquin, L., Zhu, J., Walter, V., Schell, T., Kaag, M., Kilari, D., Liao, J., Holder, S. L., Emamekhoo, H., Sankin, A., Merrill, S., Zheng, H., Warrick, J., Hauke, R., Gartrel, B., Stein, M., Drabick, J., Degraff, D. J. & Zakharia, Y., Feb 23 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006551.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment
Elcheva, I. A., Gowda, C. P., Bogush, D., Gornostaeva, S., Fakhardo, A., Sheth, N., Kokolus, K. M., Sharma, A., Dovat, S., Uzun, Y., Schell, T. D. & Spiegelman, V. S., 2023, In: Frontiers in immunology. 14, 1224516.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity
Yeware, A., Helton, A., Dong, Y., Dong, C., Pritchard, J., Mineishi, S., Minagawa, K., Schell, T. & Hayes, D., Oct 2023, In: Biochemical Engineering Journal. 199, 109068.Research output: Contribution to journal › Article › peer-review
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Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma
Pandya Shesh, B., Walter, V., Palsa, K., Slagle-Webb, B., Neely, E., Schell, T. & Connor, J. R., Sep 2023, In: Journal of neuro-oncology. 164, 3, p. 569-586 18 p.Research output: Contribution to journal › Article › peer-review
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Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges
Lü, J., Jiang, C., Schell, T. D., Joshi, M., Raman, J. D. & Xing, C., 2022, In: American Journal of Chinese Medicine. 50, 6, p. 1475-1527 53 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations