Research in Dr. Victor Ruiz-Velasco’s laboratory focuses on the modulation of Ca2+ and K+ channels by G proteins and other nucleotides, which has been the focus of his research career. Recently, his laboratory has started to investigate the modulation of acid-sensing ion channel (ASIC) currents by opioid peptides, as well as examining the role of single nucleotide polymorphisms in voltage-gated channels, NaV1.8 and NaV1.9, and pain. Over the years, he has employed a wide variety of techniques that have allowed him to study this biophysical transduction system in excitable cells, including neurons and smooth muscle cells.