Personal profile
Research interests
Research in Dr. Victor Ruiz-Velasco’s laboratory focuses on the modulation of Ca2+ and K+ channels by G proteins and other nucleotides, which has been the focus of his research career. Recently, his laboratory has started to investigate the modulation of acid-sensing ion channel (ASIC) currents by opioid peptides, as well as examining the role of single nucleotide polymorphisms in voltage-gated channels, NaV1.8 and NaV1.9, and pain. Over the years, he has employed a wide variety of techniques that have allowed him to study this biophysical transduction system in excitable cells, including neurons and smooth muscle cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 6 Finished
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Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery disease
Ruiz-Velasco, V. (PI) & Kaufman, M. (CoPI)
National Heart, Lung, and Blood Institute
4/20/21 → 3/31/24
Project: Research project
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Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses
Sinoway, L. (PI), Kaufman, M. (CoPI), Li, J. (CoPI) & Ruiz-Velasco, V. (CoPI)
National Heart, Lung, and Blood Institute
2/1/17 → 1/31/22
Project: Research project
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Core B - Transfection Core Laboratory
Ruiz-Velasco, V. (PI)
National Heart, Lung, and Blood Institute
2/1/17 → 1/31/22
Project: Research project
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Excitability of afferents evoking the exercise pressor reflex
Kaufman, M. (PI), Elmslie, K. S. (CoPI) & Ruiz-Velasco, V. (CoPI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
4/1/10 → 3/31/21
Project: Research project
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Coupling mechanisms of NOP receptors and calcium channels
Ruiz-Velasco, V. (PI) & Ruiz-Velasco, V. (CoPI)
NATIONAL INSTITUTE ON DRUG ABUSE
4/1/09 → 3/31/14
Project: Research project
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G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons
Farrag, M., Soliman, M., Mahmoud, S., Miller, L., Herold, P. B., Brandt, K. & Ruiz-Velasco, V., Jan 2026, In: Journal of Neuroscience Research. 104, 1, e70110.Research output: Contribution to journal › Article › peer-review
Open Access -
Long-chain fatty acid utilization in Eisenmenger syndrome
Cavus, O., Oza, M. J., Angelotti, A., DeSalvo, J., Koo, I., Ruiz-Velasco, V. & Bradley, E. A., Jan 1 2026, In: Progress in Pediatric cardiology. 80, 101902.Research output: Contribution to journal › Article › peer-review
Open Access -
Myophosphorylase Knock Out Prevents the Exaggerated Exercise Pressor Reflex in Rats With Simulated Peripheral Artery Disease
Ducrocq, G. P., Anselmi, L., Ruiz-Velasco, V. & Kaufman, M. P., Mar 2026, In: Acta Physiologica. 242, 3, e70172.Research output: Contribution to journal › Article › peer-review
Open Access -
Functional knock out of Acid Sensing Ion Channel 3 prevents the exaggerated exercise pressor reflex in rats exercising on a treadmill
Thomas, G. D., Higgins, S. P., Kuczmarski, M. J., Ducrocq, G. P., Anselmi, L., Ruiz-Velasco, V. & Kaufman, M. P., Apr 2025, In: Autonomic Neuroscience: Basic and Clinical. 258, 103249.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats
Ducrocq, G. P., Anselmi, L., Stella, S. L., Copp, S. W., Ruiz-Velasco, V. & Kaufman, M. P., Sep 15 2025, In: Journal of Physiology. 603, 18, p. 5027-5052 26 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations